The Associations of Arterial Stiffness and Central Hemodynamics with Carotid Atherosclerosis in Patients at a High Coronary Risk: A Cross-Sectional Study
Introduction: It is not well-known which indicator, central blood pressure (CBP) or arterial stiffness, has a greater impact on carotid atherosclerosis. This study aimed to assess the associations of carotid atherosclerosis with arterial stiffness and CBP in the same individuals. Methods:...
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Karger Publishers
2025-01-01
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| Online Access: | https://karger.com/article/doi/10.1159/000543001 |
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| author | Hack-Lyoung Kim Soonil Kwon Hyun Sung Joh Woo-Hyun Lim Jae-Bin Seo Sang-Hyun Kim Joo-Hee Zo Myung-A Kim |
| author_facet | Hack-Lyoung Kim Soonil Kwon Hyun Sung Joh Woo-Hyun Lim Jae-Bin Seo Sang-Hyun Kim Joo-Hee Zo Myung-A Kim |
| author_sort | Hack-Lyoung Kim |
| collection | DOAJ |
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Introduction: It is not well-known which indicator, central blood pressure (CBP) or arterial stiffness, has a greater impact on carotid atherosclerosis. This study aimed to assess the associations of carotid atherosclerosis with arterial stiffness and CBP in the same individuals. Methods: A total of 142 patients (mean age: 69 years; 43% female) with documented atherosclerotic cardiovascular disease or multiple risk factors were analyzed. Brachial-ankle pulse wave velocity (baPWV) and CBP measurements, along with carotid ultrasound, were performed on the same day. CBP was assessed using radial artery tonometry. Results: In simple linear regression analysis, only baPWV exhibited a significant correlation with carotid intima-media thickness (CIMT) (r = 0.272; p = 0.001), whereas none of the CBP parameters (systolic, diastolic, pulse pressures, and augmentation index) correlated with CIMT (p > 0.05 for each). Multiple linear regression analysis indicated that baPWV had no significant association with CIMT after adjusting for age (p = 0.264). A higher baPWV (≥1,656 cm/s) was significantly associated with carotid plaque presence, even after accounting for potential confounders (odds ratio: 3.66; 95% confidence interval: 1.65–8.12; p = 0.001). Moreover, as the number of carotid plaques increased, there was a linear rise in baPWV (p < 0.001). None of CBP parameters were associated with the presence of carotid plaque (p > 0.05 for each). Conclusions: Among a high-risk Korean population, baPWV demonstrated a stronger association with carotid plaque presence and extent compared to CBP parameters. Thus, baPWV may serve as a valuable marker for identifying carotid plaque. |
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| institution | OA Journals |
| issn | 2235-8668 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Karger Publishers |
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| series | Pulse |
| spelling | doaj-art-40219aa4ccc046ed963c2a05ae9684b62025-08-20T01:51:03ZengKarger PublishersPulse2235-86682025-01-01131112110.1159/000543001The Associations of Arterial Stiffness and Central Hemodynamics with Carotid Atherosclerosis in Patients at a High Coronary Risk: A Cross-Sectional StudyHack-Lyoung KimSoonil KwonHyun Sung JohWoo-Hyun LimJae-Bin SeoSang-Hyun KimJoo-Hee ZoMyung-A Kim Introduction: It is not well-known which indicator, central blood pressure (CBP) or arterial stiffness, has a greater impact on carotid atherosclerosis. This study aimed to assess the associations of carotid atherosclerosis with arterial stiffness and CBP in the same individuals. Methods: A total of 142 patients (mean age: 69 years; 43% female) with documented atherosclerotic cardiovascular disease or multiple risk factors were analyzed. Brachial-ankle pulse wave velocity (baPWV) and CBP measurements, along with carotid ultrasound, were performed on the same day. CBP was assessed using radial artery tonometry. Results: In simple linear regression analysis, only baPWV exhibited a significant correlation with carotid intima-media thickness (CIMT) (r = 0.272; p = 0.001), whereas none of the CBP parameters (systolic, diastolic, pulse pressures, and augmentation index) correlated with CIMT (p > 0.05 for each). Multiple linear regression analysis indicated that baPWV had no significant association with CIMT after adjusting for age (p = 0.264). A higher baPWV (≥1,656 cm/s) was significantly associated with carotid plaque presence, even after accounting for potential confounders (odds ratio: 3.66; 95% confidence interval: 1.65–8.12; p = 0.001). Moreover, as the number of carotid plaques increased, there was a linear rise in baPWV (p < 0.001). None of CBP parameters were associated with the presence of carotid plaque (p > 0.05 for each). Conclusions: Among a high-risk Korean population, baPWV demonstrated a stronger association with carotid plaque presence and extent compared to CBP parameters. Thus, baPWV may serve as a valuable marker for identifying carotid plaque. https://karger.com/article/doi/10.1159/000543001 |
| spellingShingle | Hack-Lyoung Kim Soonil Kwon Hyun Sung Joh Woo-Hyun Lim Jae-Bin Seo Sang-Hyun Kim Joo-Hee Zo Myung-A Kim The Associations of Arterial Stiffness and Central Hemodynamics with Carotid Atherosclerosis in Patients at a High Coronary Risk: A Cross-Sectional Study Pulse |
| title | The Associations of Arterial Stiffness and Central Hemodynamics with Carotid Atherosclerosis in Patients at a High Coronary Risk: A Cross-Sectional Study |
| title_full | The Associations of Arterial Stiffness and Central Hemodynamics with Carotid Atherosclerosis in Patients at a High Coronary Risk: A Cross-Sectional Study |
| title_fullStr | The Associations of Arterial Stiffness and Central Hemodynamics with Carotid Atherosclerosis in Patients at a High Coronary Risk: A Cross-Sectional Study |
| title_full_unstemmed | The Associations of Arterial Stiffness and Central Hemodynamics with Carotid Atherosclerosis in Patients at a High Coronary Risk: A Cross-Sectional Study |
| title_short | The Associations of Arterial Stiffness and Central Hemodynamics with Carotid Atherosclerosis in Patients at a High Coronary Risk: A Cross-Sectional Study |
| title_sort | associations of arterial stiffness and central hemodynamics with carotid atherosclerosis in patients at a high coronary risk a cross sectional study |
| url | https://karger.com/article/doi/10.1159/000543001 |
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