Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States
BackgroundAbdominal aortic calcification (AAC), an early indicator of abdominal aortic wall atherosclerosis, is a marker of subclinical atherosclerosis and a predictive factor for vascular-associated morbidity and mortality. These outcomes are driven by inflammatory processes. Given the pivotal role...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1496552/full |
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| author | Hao Deng Mengmeng Sun Zhentong Zhao Kun Fan Zizhang Zhao Yifan Chi Wei Sheng |
| author_facet | Hao Deng Mengmeng Sun Zhentong Zhao Kun Fan Zizhang Zhao Yifan Chi Wei Sheng |
| author_sort | Hao Deng |
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| description | BackgroundAbdominal aortic calcification (AAC), an early indicator of abdominal aortic wall atherosclerosis, is a marker of subclinical atherosclerosis and a predictive factor for vascular-associated morbidity and mortality. These outcomes are driven by inflammatory processes. Given the pivotal role of inflammatory mediators in the pathogenesis of aortic calcification, inflammation has attracted interest as a peripheral biomarker for early mortality prediction in patients with aortic calcification. The neutrophil-to-lymphocyte ratio (NLR) measured in the peripheral blood typically reflects the body's inflammatory response by combining laboratory markers of innate and adaptive immunity. The NLR is associated with the prognosis of a range of diseases, including circulatory, infectious, psychiatric, and neoplastic conditions. However, the precise relationship between the NLR and vascular calcification remains unclear. Therefore, the present study investigated the correlation between the NLR and AAC in a nationally representative sample from the US.MethodsThis study analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2013–2014. Multivariable logistic regression, stratified analysis with interaction, and restricted cubic spline analysis were used to examine the relationship between the NLR and AAC.ResultsThis study enrolled 3,047 participants [1,469 men (48.2%) and 1,578 women (51.8%)]. After adjusting for all covariates in the multivariate logistic regression, an independent association was identified between augmented NLR and the incidence of severe AAC (SAAC). The risk of SAAC increased by 8% with every 1% increase in NLR. Compared with the lowest NLR group [quartile 1 (Q1), <1.64], the adjusted odds ratio values for NLR and SAAC in Q3 (>2.34) were 1.42 (95% confidence interval: 1.02–1.96, p = 0.037), respectively. The results of subgroup analyses revealed no significant interaction effects.ConclusionsThe NLR was positively correlated with SAAC prevalence among adults in the US. These findings have significant clinical relevance and may inform clinicians regarding the management of SAAC. However, further research is required to confirm this association. |
| format | Article |
| id | doaj-art-401c4e40162f408eaf992505820e91ba |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-401c4e40162f408eaf992505820e91ba2025-02-11T07:00:04ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-02-011210.3389/fcvm.2025.14965521496552Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United StatesHao Deng0Mengmeng Sun1Zhentong Zhao2Kun Fan3Zizhang Zhao4Yifan Chi5Wei Sheng6Department of Heart Center, QingDao Hiser Hospital Affiliated of Qingdao University, QingDao, ShangDong, ChinaDepartment of Thyroid Surgery, QingDao Municipal Hospital, QingDao, ShangDong, ChinaDepartment of Heart Center, QingDao Hiser Hospital Affiliated of Qingdao University, QingDao, ShangDong, ChinaDepartment of Heart Center, QingDao Hiser Hospital Affiliated of Qingdao University, QingDao, ShangDong, ChinaDepartment of Heart Center, QingDao Hiser Hospital Affiliated of Qingdao University, QingDao, ShangDong, ChinaDepartment of Heart Center, QingDao Hiser Hospital Affiliated of Qingdao University, QingDao, ShangDong, ChinaDepartment of Heart Center, QingDao Hiser Hospital Affiliated of Qingdao University, QingDao, ShangDong, ChinaBackgroundAbdominal aortic calcification (AAC), an early indicator of abdominal aortic wall atherosclerosis, is a marker of subclinical atherosclerosis and a predictive factor for vascular-associated morbidity and mortality. These outcomes are driven by inflammatory processes. Given the pivotal role of inflammatory mediators in the pathogenesis of aortic calcification, inflammation has attracted interest as a peripheral biomarker for early mortality prediction in patients with aortic calcification. The neutrophil-to-lymphocyte ratio (NLR) measured in the peripheral blood typically reflects the body's inflammatory response by combining laboratory markers of innate and adaptive immunity. The NLR is associated with the prognosis of a range of diseases, including circulatory, infectious, psychiatric, and neoplastic conditions. However, the precise relationship between the NLR and vascular calcification remains unclear. Therefore, the present study investigated the correlation between the NLR and AAC in a nationally representative sample from the US.MethodsThis study analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2013–2014. Multivariable logistic regression, stratified analysis with interaction, and restricted cubic spline analysis were used to examine the relationship between the NLR and AAC.ResultsThis study enrolled 3,047 participants [1,469 men (48.2%) and 1,578 women (51.8%)]. After adjusting for all covariates in the multivariate logistic regression, an independent association was identified between augmented NLR and the incidence of severe AAC (SAAC). The risk of SAAC increased by 8% with every 1% increase in NLR. Compared with the lowest NLR group [quartile 1 (Q1), <1.64], the adjusted odds ratio values for NLR and SAAC in Q3 (>2.34) were 1.42 (95% confidence interval: 1.02–1.96, p = 0.037), respectively. The results of subgroup analyses revealed no significant interaction effects.ConclusionsThe NLR was positively correlated with SAAC prevalence among adults in the US. These findings have significant clinical relevance and may inform clinicians regarding the management of SAAC. However, further research is required to confirm this association.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1496552/fullabdominal aortic calcificationatherosclerosisinflammationneutrophil-tolymphocyte ratioretrospective study |
| spellingShingle | Hao Deng Mengmeng Sun Zhentong Zhao Kun Fan Zizhang Zhao Yifan Chi Wei Sheng Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States Frontiers in Cardiovascular Medicine abdominal aortic calcification atherosclerosis inflammation neutrophil-tolymphocyte ratio retrospective study |
| title | Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States |
| title_full | Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States |
| title_fullStr | Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States |
| title_full_unstemmed | Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States |
| title_short | Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States |
| title_sort | association of neutrophil to lymphocyte ratio with severe abdominal aortic calcification new evidence from the united states |
| topic | abdominal aortic calcification atherosclerosis inflammation neutrophil-tolymphocyte ratio retrospective study |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1496552/full |
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