Androgen Receptors Expression in Pituitary of Male Viscacha in relation to Growth and Reproductive Cycle
The aim of this work was to study the androgen receptors (AR) expression in pituitary pars distalis (PD) of male viscachas in relation to growth and reproductive cycle. AR were detected by immunocytochemistry and quantified by image analysis. Pituitary glands from fetus, immature, prepubertal, and a...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/168047 |
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| author | Verónica Palmira Filippa Gabriela Judith Rosales Albana Andrea Marina Cruceño Fabian Heber Mohamed |
| author_facet | Verónica Palmira Filippa Gabriela Judith Rosales Albana Andrea Marina Cruceño Fabian Heber Mohamed |
| author_sort | Verónica Palmira Filippa |
| collection | DOAJ |
| description | The aim of this work was to study the androgen receptors (AR) expression in pituitary pars distalis (PD) of male viscachas in relation to growth and reproductive cycle. AR were detected by immunocytochemistry and quantified by image analysis. Pituitary glands from fetus, immature, prepubertal, and adult viscachas during their reproductive cycle were used. In the fetal PD, the immunoreactivity (ir) was mainly cytoplasmic. In immature and prepubertal animals, AR-ir was cytoplasmic (ARc-ir) and nuclear (ARn-ir) in medial region. In adult animals, ARn-ir cells were numerous at caudal end. AR regionalization varied between the PD zones in relation to growth. In immature animals, the ARn-ir increased whereas the cytoplasmic expression decreased in relation to the fetal glands. The percentage of ARc-ir cells increased in prepubertal animals whereas the nuclear AR expression was predominant in adult viscachas. The AR expression changed in adults, showing minimum percentage in the gonadal regression period. The variation of nuclear AR expression was directly related with testosterone concentration. These results demonstrated variations in the immunostaining pattern, regionalization, and number of AR-ir cells throughout development, growth, and reproductive cycle, suggesting the involvement of AR in the regulation of the pituitary activity of male viscacha. |
| format | Article |
| id | doaj-art-401a6872e66f4b9eaf2fdb099e101302 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-401a6872e66f4b9eaf2fdb099e1013022025-08-20T03:55:36ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/168047168047Androgen Receptors Expression in Pituitary of Male Viscacha in relation to Growth and Reproductive CycleVerónica Palmira Filippa0Gabriela Judith Rosales1Albana Andrea Marina Cruceño2Fabian Heber Mohamed3Histología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Avenida Ejército de los Andes 950, Bloque I, Piso No. 1, 5700 San Luis, ArgentinaHistología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Avenida Ejército de los Andes 950, Bloque I, Piso No. 1, 5700 San Luis, ArgentinaHistología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Avenida Ejército de los Andes 950, Bloque I, Piso No. 1, 5700 San Luis, ArgentinaHistología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Avenida Ejército de los Andes 950, Bloque I, Piso No. 1, 5700 San Luis, ArgentinaThe aim of this work was to study the androgen receptors (AR) expression in pituitary pars distalis (PD) of male viscachas in relation to growth and reproductive cycle. AR were detected by immunocytochemistry and quantified by image analysis. Pituitary glands from fetus, immature, prepubertal, and adult viscachas during their reproductive cycle were used. In the fetal PD, the immunoreactivity (ir) was mainly cytoplasmic. In immature and prepubertal animals, AR-ir was cytoplasmic (ARc-ir) and nuclear (ARn-ir) in medial region. In adult animals, ARn-ir cells were numerous at caudal end. AR regionalization varied between the PD zones in relation to growth. In immature animals, the ARn-ir increased whereas the cytoplasmic expression decreased in relation to the fetal glands. The percentage of ARc-ir cells increased in prepubertal animals whereas the nuclear AR expression was predominant in adult viscachas. The AR expression changed in adults, showing minimum percentage in the gonadal regression period. The variation of nuclear AR expression was directly related with testosterone concentration. These results demonstrated variations in the immunostaining pattern, regionalization, and number of AR-ir cells throughout development, growth, and reproductive cycle, suggesting the involvement of AR in the regulation of the pituitary activity of male viscacha.http://dx.doi.org/10.1155/2015/168047 |
| spellingShingle | Verónica Palmira Filippa Gabriela Judith Rosales Albana Andrea Marina Cruceño Fabian Heber Mohamed Androgen Receptors Expression in Pituitary of Male Viscacha in relation to Growth and Reproductive Cycle International Journal of Endocrinology |
| title | Androgen Receptors Expression in Pituitary of Male Viscacha in relation to Growth and Reproductive Cycle |
| title_full | Androgen Receptors Expression in Pituitary of Male Viscacha in relation to Growth and Reproductive Cycle |
| title_fullStr | Androgen Receptors Expression in Pituitary of Male Viscacha in relation to Growth and Reproductive Cycle |
| title_full_unstemmed | Androgen Receptors Expression in Pituitary of Male Viscacha in relation to Growth and Reproductive Cycle |
| title_short | Androgen Receptors Expression in Pituitary of Male Viscacha in relation to Growth and Reproductive Cycle |
| title_sort | androgen receptors expression in pituitary of male viscacha in relation to growth and reproductive cycle |
| url | http://dx.doi.org/10.1155/2015/168047 |
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