Safety evaluation of an extension of use of the food enzyme glucose oxidase from the genetically modified Aspergillus niger strain ZGL
Abstract The food enzyme glucose oxidase (β‐d‐glucose: oxygen 1‐oxidoreductase, EC 1.1.3.4) is produced with the genetically modified Aspergillus niger strain ZGL by DSM Food Specialties B.V. A safety evaluation of this food enzyme was made previously, in which EFSA concluded that this food enzyme d...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | EFSA Journal |
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| Online Access: | https://doi.org/10.2903/j.efsa.2025.9224 |
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| author | EFSA Panel on Food Enzymes (FEZ) Holger Zorn José Manuel Barat Baviera Claudia Bolognesi Francesco Catania Gabriele Gadermaier Ralf Greiner Baltasar Mayo Alicja Mortensen Yrjö Henrik Roos Marize L. M. Solano Monika Sramkova Henk Van Loveren Laurence Vernis Daniele Cavanna Yi Liu |
| author_facet | EFSA Panel on Food Enzymes (FEZ) Holger Zorn José Manuel Barat Baviera Claudia Bolognesi Francesco Catania Gabriele Gadermaier Ralf Greiner Baltasar Mayo Alicja Mortensen Yrjö Henrik Roos Marize L. M. Solano Monika Sramkova Henk Van Loveren Laurence Vernis Daniele Cavanna Yi Liu |
| author_sort | EFSA Panel on Food Enzymes (FEZ) |
| collection | DOAJ |
| description | Abstract The food enzyme glucose oxidase (β‐d‐glucose: oxygen 1‐oxidoreductase, EC 1.1.3.4) is produced with the genetically modified Aspergillus niger strain ZGL by DSM Food Specialties B.V. A safety evaluation of this food enzyme was made previously, in which EFSA concluded that this food enzyme did not give rise to safety concerns when used in one food manufacturing process. Subsequently, the applicant has requested to extend its use to include one additional process. In this assessment, EFSA updated the safety evaluation of this food enzyme when used in a total of two food manufacturing processes. Dietary exposure was calculated to be up to 0.025 mg TOS/kg body weight (bw) per day in European populations. When combined with the no observed adverse effect level (NOAEL) previously reported (1038 mg TOS/kg bw per day, the highest dose tested), the Panel derived a margin of exposure of at least 41,520. Based on the new data, the revised margin of exposure and the previous evaluation, the Panel concluded that this food enzyme does not give rise to safety concerns under the revised intended conditions of use. |
| format | Article |
| id | doaj-art-401a08cd46514752a7d1e5a189ec85d2 |
| institution | Kabale University |
| issn | 1831-4732 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj-art-401a08cd46514752a7d1e5a189ec85d22025-01-31T12:06:04ZengWileyEFSA Journal1831-47322025-01-01231n/an/a10.2903/j.efsa.2025.9224Safety evaluation of an extension of use of the food enzyme glucose oxidase from the genetically modified Aspergillus niger strain ZGLEFSA Panel on Food Enzymes (FEZ)Holger ZornJosé Manuel Barat BavieraClaudia BolognesiFrancesco CataniaGabriele GadermaierRalf GreinerBaltasar MayoAlicja MortensenYrjö Henrik RoosMarize L. M. SolanoMonika SramkovaHenk Van LoverenLaurence VernisDaniele CavannaYi LiuAbstract The food enzyme glucose oxidase (β‐d‐glucose: oxygen 1‐oxidoreductase, EC 1.1.3.4) is produced with the genetically modified Aspergillus niger strain ZGL by DSM Food Specialties B.V. A safety evaluation of this food enzyme was made previously, in which EFSA concluded that this food enzyme did not give rise to safety concerns when used in one food manufacturing process. Subsequently, the applicant has requested to extend its use to include one additional process. In this assessment, EFSA updated the safety evaluation of this food enzyme when used in a total of two food manufacturing processes. Dietary exposure was calculated to be up to 0.025 mg TOS/kg body weight (bw) per day in European populations. When combined with the no observed adverse effect level (NOAEL) previously reported (1038 mg TOS/kg bw per day, the highest dose tested), the Panel derived a margin of exposure of at least 41,520. Based on the new data, the revised margin of exposure and the previous evaluation, the Panel concluded that this food enzyme does not give rise to safety concerns under the revised intended conditions of use.https://doi.org/10.2903/j.efsa.2025.9224Aspergillus nigerEC 1.1.3.4EFSA‐Q‐2013‐01005EFSA‐Q‐2024‐00294food enzymegenetically modified microorganism |
| spellingShingle | EFSA Panel on Food Enzymes (FEZ) Holger Zorn José Manuel Barat Baviera Claudia Bolognesi Francesco Catania Gabriele Gadermaier Ralf Greiner Baltasar Mayo Alicja Mortensen Yrjö Henrik Roos Marize L. M. Solano Monika Sramkova Henk Van Loveren Laurence Vernis Daniele Cavanna Yi Liu Safety evaluation of an extension of use of the food enzyme glucose oxidase from the genetically modified Aspergillus niger strain ZGL EFSA Journal Aspergillus niger EC 1.1.3.4 EFSA‐Q‐2013‐01005 EFSA‐Q‐2024‐00294 food enzyme genetically modified microorganism |
| title | Safety evaluation of an extension of use of the food enzyme glucose oxidase from the genetically modified Aspergillus niger strain ZGL |
| title_full | Safety evaluation of an extension of use of the food enzyme glucose oxidase from the genetically modified Aspergillus niger strain ZGL |
| title_fullStr | Safety evaluation of an extension of use of the food enzyme glucose oxidase from the genetically modified Aspergillus niger strain ZGL |
| title_full_unstemmed | Safety evaluation of an extension of use of the food enzyme glucose oxidase from the genetically modified Aspergillus niger strain ZGL |
| title_short | Safety evaluation of an extension of use of the food enzyme glucose oxidase from the genetically modified Aspergillus niger strain ZGL |
| title_sort | safety evaluation of an extension of use of the food enzyme glucose oxidase from the genetically modified aspergillus niger strain zgl |
| topic | Aspergillus niger EC 1.1.3.4 EFSA‐Q‐2013‐01005 EFSA‐Q‐2024‐00294 food enzyme genetically modified microorganism |
| url | https://doi.org/10.2903/j.efsa.2025.9224 |
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