Central precocious puberty associated with duplicated pituitary: a case report and literature review
Patients with duplicated pituitary often have severe neurodevelopmental abnormalities and craniofacial deformities. Till now, only eight patients diagnosed with duplicated pituitary showing barely central precocious puberty (CPP) are reported in the published literature. Herein, we report a 6-year-o...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1466411/full |
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| author | Kun Yang Yanmei Sang Yanmei Sang Li Dai Weizhong Wang |
| author_facet | Kun Yang Yanmei Sang Yanmei Sang Li Dai Weizhong Wang |
| author_sort | Kun Yang |
| collection | DOAJ |
| description | Patients with duplicated pituitary often have severe neurodevelopmental abnormalities and craniofacial deformities. Till now, only eight patients diagnosed with duplicated pituitary showing barely central precocious puberty (CPP) are reported in the published literature. Herein, we report a 6-year-old and 3-month-old girl diagnosed with pituitary duplication presented with CPP. She has enlarged breasts for more than 1 year, accelerated height of linear growth, advanced bone age, increased hormone level, and increased volume of uterus and ovary. A duplicated pituitary gland was shown in the MRI. As the gonadotropin-releasing hormone analogue (GnRHa) stimulation test showed a positive result, the child was treated with GnRHa. After 2 years of follow-up, there was a delay in the progression of sexual development, a reduction in symptoms of precocious puberty, and an increase in predicted adult height. |
| format | Article |
| id | doaj-art-401904e9d719412b85c53052b7b91575 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-401904e9d719412b85c53052b7b915752025-02-11T05:10:17ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.14664111466411Central precocious puberty associated with duplicated pituitary: a case report and literature reviewKun Yang0Yanmei Sang1Yanmei Sang2Li Dai3Weizhong Wang4Baoding Hospital, Beijing Children’s Hospital affiliated to Capital Medical University, Baoding, Hebei, ChinaDepartment of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical University, Beijing, ChinaBeijing Key Laboratory for Genetics of Birth Defects, Beijing, ChinaBaoding Hospital, Beijing Children’s Hospital affiliated to Capital Medical University, Baoding, Hebei, ChinaBaoding Hospital, Beijing Children’s Hospital affiliated to Capital Medical University, Baoding, Hebei, ChinaPatients with duplicated pituitary often have severe neurodevelopmental abnormalities and craniofacial deformities. Till now, only eight patients diagnosed with duplicated pituitary showing barely central precocious puberty (CPP) are reported in the published literature. Herein, we report a 6-year-old and 3-month-old girl diagnosed with pituitary duplication presented with CPP. She has enlarged breasts for more than 1 year, accelerated height of linear growth, advanced bone age, increased hormone level, and increased volume of uterus and ovary. A duplicated pituitary gland was shown in the MRI. As the gonadotropin-releasing hormone analogue (GnRHa) stimulation test showed a positive result, the child was treated with GnRHa. After 2 years of follow-up, there was a delay in the progression of sexual development, a reduction in symptoms of precocious puberty, and an increase in predicted adult height.https://www.frontiersin.org/articles/10.3389/fendo.2025.1466411/fullGnRHacentral precocious puberty (CPP)duplicated pituitaryfemaleheight |
| spellingShingle | Kun Yang Yanmei Sang Yanmei Sang Li Dai Weizhong Wang Central precocious puberty associated with duplicated pituitary: a case report and literature review Frontiers in Endocrinology GnRHa central precocious puberty (CPP) duplicated pituitary female height |
| title | Central precocious puberty associated with duplicated pituitary: a case report and literature review |
| title_full | Central precocious puberty associated with duplicated pituitary: a case report and literature review |
| title_fullStr | Central precocious puberty associated with duplicated pituitary: a case report and literature review |
| title_full_unstemmed | Central precocious puberty associated with duplicated pituitary: a case report and literature review |
| title_short | Central precocious puberty associated with duplicated pituitary: a case report and literature review |
| title_sort | central precocious puberty associated with duplicated pituitary a case report and literature review |
| topic | GnRHa central precocious puberty (CPP) duplicated pituitary female height |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1466411/full |
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