Prognostic value of survivin in patients with non-small cell lung carcinoma: a systematic review with meta-analysis.
<h4>Purpose</h4>The potential prognostic value of survivin in resected non-small cell lung carcinoma (NSCLC) is variably reported. The objective of this study was to conduct a systematic review of literatures evaluating survivin expression in resected NSCLC as a prognostic indicator.<...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0034100&type=printable |
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| author | Lou Qian Zhang Jun Wang Feng Jiang Lin Xu Fu Yin Liu Rong Yin |
| author_facet | Lou Qian Zhang Jun Wang Feng Jiang Lin Xu Fu Yin Liu Rong Yin |
| author_sort | Lou Qian Zhang |
| collection | DOAJ |
| description | <h4>Purpose</h4>The potential prognostic value of survivin in resected non-small cell lung carcinoma (NSCLC) is variably reported. The objective of this study was to conduct a systematic review of literatures evaluating survivin expression in resected NSCLC as a prognostic indicator.<h4>Methods</h4>Relevant literatures were identified using PubMed, EMBASE and Chinese Biomedicine Databases. We present the results of a meta-analysis of the association between survivin expression and overall survival (OS) in NSCLC patients. Studies were pooled and summary hazard ratios (HR) were calculated. Subgroup analyses and publication bias were also conducted.<h4>Results</h4>We performed a final analysis of 2703 patients from 28 evaluable studies. Combined HRs suggested that survivin overexpression had an unfavorable impact on NSCLC patients' survival with no evidence of any significant publication bias (HR = 2.03, 95%CI: 1.78-2.33, Egger's test, P = 0.24) and no severe heterogeneity between studies (I² = 26.9%). Its effect also appeared significant when stratified according to the studies categorized by histological type, HR estimate, patient race, cutoff point (5%, 10%), detection methods and literature written language except for disease stage. Survivin was identified as a prognostic marker of advanced-stage NSCLC (HR = 1.93, 95%CI: 1.49-2.51), but not early-stage NSCLC (HR = 1.97, 95%CI: 0.76-5.14), in spite of the combined data being relatively small.<h4>Conclusion</h4>This study shows that survivin expression appears to be a pejorative prognostic factor in terms of overall survival in surgically treated NSCLC. Large prospective studies are now needed to confirm the clinical utility of survivin as an independent prognostic marker. |
| format | Article |
| id | doaj-art-401226bcc0cd4bd19b1a3596145164ed |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-401226bcc0cd4bd19b1a3596145164ed2025-08-20T03:24:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0173e3410010.1371/journal.pone.0034100Prognostic value of survivin in patients with non-small cell lung carcinoma: a systematic review with meta-analysis.Lou Qian ZhangJun WangFeng JiangLin XuFu Yin LiuRong Yin<h4>Purpose</h4>The potential prognostic value of survivin in resected non-small cell lung carcinoma (NSCLC) is variably reported. The objective of this study was to conduct a systematic review of literatures evaluating survivin expression in resected NSCLC as a prognostic indicator.<h4>Methods</h4>Relevant literatures were identified using PubMed, EMBASE and Chinese Biomedicine Databases. We present the results of a meta-analysis of the association between survivin expression and overall survival (OS) in NSCLC patients. Studies were pooled and summary hazard ratios (HR) were calculated. Subgroup analyses and publication bias were also conducted.<h4>Results</h4>We performed a final analysis of 2703 patients from 28 evaluable studies. Combined HRs suggested that survivin overexpression had an unfavorable impact on NSCLC patients' survival with no evidence of any significant publication bias (HR = 2.03, 95%CI: 1.78-2.33, Egger's test, P = 0.24) and no severe heterogeneity between studies (I² = 26.9%). Its effect also appeared significant when stratified according to the studies categorized by histological type, HR estimate, patient race, cutoff point (5%, 10%), detection methods and literature written language except for disease stage. Survivin was identified as a prognostic marker of advanced-stage NSCLC (HR = 1.93, 95%CI: 1.49-2.51), but not early-stage NSCLC (HR = 1.97, 95%CI: 0.76-5.14), in spite of the combined data being relatively small.<h4>Conclusion</h4>This study shows that survivin expression appears to be a pejorative prognostic factor in terms of overall survival in surgically treated NSCLC. Large prospective studies are now needed to confirm the clinical utility of survivin as an independent prognostic marker.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0034100&type=printable |
| spellingShingle | Lou Qian Zhang Jun Wang Feng Jiang Lin Xu Fu Yin Liu Rong Yin Prognostic value of survivin in patients with non-small cell lung carcinoma: a systematic review with meta-analysis. PLoS ONE |
| title | Prognostic value of survivin in patients with non-small cell lung carcinoma: a systematic review with meta-analysis. |
| title_full | Prognostic value of survivin in patients with non-small cell lung carcinoma: a systematic review with meta-analysis. |
| title_fullStr | Prognostic value of survivin in patients with non-small cell lung carcinoma: a systematic review with meta-analysis. |
| title_full_unstemmed | Prognostic value of survivin in patients with non-small cell lung carcinoma: a systematic review with meta-analysis. |
| title_short | Prognostic value of survivin in patients with non-small cell lung carcinoma: a systematic review with meta-analysis. |
| title_sort | prognostic value of survivin in patients with non small cell lung carcinoma a systematic review with meta analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0034100&type=printable |
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