Synthesis and Biological Evaluation of Some New Chalcones Containing 2,5-Dimethylfuran Moiety
A series of new chalcones (3a-g) were prepared by Claisen-Schmidt condensation of 3-acetyl-2,5-dimethylfuran with various substituted aromatic aldehydes in presence of aqueous solution of potassium hydroxide and ethanol at room temperature. The synthesized chalcones were characterized by means of th...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/582603 |
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| author | S. Sridhar S. C. Dinda Y. Rajendra Prasad |
| author_facet | S. Sridhar S. C. Dinda Y. Rajendra Prasad |
| author_sort | S. Sridhar |
| collection | DOAJ |
| description | A series of new chalcones (3a-g) were prepared by Claisen-Schmidt condensation of 3-acetyl-2,5-dimethylfuran with various substituted aromatic aldehydes in presence of aqueous solution of potassium hydroxide and ethanol at room temperature. The synthesized chalcones were characterized by means of their IR, 1H NMR spectral data and elemental analyses. When these chalcones were evaluated for antimicrobial and anti-inflammatory activities, some of them were found to possess significant activity, when compared to standard drugs. |
| format | Article |
| id | doaj-art-40035e708b624ce6ac0ab27aa8e19069 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-40035e708b624ce6ac0ab27aa8e190692025-02-03T01:30:35ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-018254154610.1155/2011/582603Synthesis and Biological Evaluation of Some New Chalcones Containing 2,5-Dimethylfuran MoietyS. Sridhar0S. C. Dinda1Y. Rajendra Prasad2Chebrolu Hanumaiah Institute of Pharmaceutical Sciences Guntur, A.P., IndiaSchool of Pharmaceutical Education and Research Berhampur University, Berhampur, Orissa, IndiaUniversity College of Pharmaceutical Sciences Andhra University, Vishakapatanam, A.P., IndiaA series of new chalcones (3a-g) were prepared by Claisen-Schmidt condensation of 3-acetyl-2,5-dimethylfuran with various substituted aromatic aldehydes in presence of aqueous solution of potassium hydroxide and ethanol at room temperature. The synthesized chalcones were characterized by means of their IR, 1H NMR spectral data and elemental analyses. When these chalcones were evaluated for antimicrobial and anti-inflammatory activities, some of them were found to possess significant activity, when compared to standard drugs.http://dx.doi.org/10.1155/2011/582603 |
| spellingShingle | S. Sridhar S. C. Dinda Y. Rajendra Prasad Synthesis and Biological Evaluation of Some New Chalcones Containing 2,5-Dimethylfuran Moiety E-Journal of Chemistry |
| title | Synthesis and Biological Evaluation of Some New Chalcones Containing 2,5-Dimethylfuran Moiety |
| title_full | Synthesis and Biological Evaluation of Some New Chalcones Containing 2,5-Dimethylfuran Moiety |
| title_fullStr | Synthesis and Biological Evaluation of Some New Chalcones Containing 2,5-Dimethylfuran Moiety |
| title_full_unstemmed | Synthesis and Biological Evaluation of Some New Chalcones Containing 2,5-Dimethylfuran Moiety |
| title_short | Synthesis and Biological Evaluation of Some New Chalcones Containing 2,5-Dimethylfuran Moiety |
| title_sort | synthesis and biological evaluation of some new chalcones containing 2 5 dimethylfuran moiety |
| url | http://dx.doi.org/10.1155/2011/582603 |
| work_keys_str_mv | AT ssridhar synthesisandbiologicalevaluationofsomenewchalconescontaining25dimethylfuranmoiety AT scdinda synthesisandbiologicalevaluationofsomenewchalconescontaining25dimethylfuranmoiety AT yrajendraprasad synthesisandbiologicalevaluationofsomenewchalconescontaining25dimethylfuranmoiety |