Examining efficacy and safety of ethyl acetate extract from Allium hirtifolium as complementary therapy in COVID-19: A randomized, multicenter, controlled clinical trial
Objective: Given the apparent life-threatening nature of COVID-19, finding an effective treatment is under investigation.Materials and Methods: We assessed effect of shallomin oral syrup (co IranAmin®) as a complementary treatment to improve the clinical outcomes in COVID-19 patients. Patients in th...
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Mashhad University of Medical Sciences
2024-11-01
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| Series: | Avicenna Journal of Phytomedicine |
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| Online Access: | https://ajp.mums.ac.ir/article_24523_def74760f8707a71af68e3a36582b6c5.pdf |
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| author | Mansour Amin Mandana Pouladzadeh Mohammad Jaafar Yadyad Roshanak Roshanfard Mohamad Hasan Pipelzadeh Afshin Talebi Behzad Sharif Maakhmalzadeh Mehdi Bijanzadeh Nasrin Rakipour Gholamreza Alizadehattar Seyed Saeed Seyedian Kambiz Ahmadi Angali Parastoo Moradi Choghakabodi Akbar Akbari Fatemeh Maghsodi Ebrahim Barzegari Maryam Jamalan Reza Aalizadeh Mostafa Jamalan |
| author_facet | Mansour Amin Mandana Pouladzadeh Mohammad Jaafar Yadyad Roshanak Roshanfard Mohamad Hasan Pipelzadeh Afshin Talebi Behzad Sharif Maakhmalzadeh Mehdi Bijanzadeh Nasrin Rakipour Gholamreza Alizadehattar Seyed Saeed Seyedian Kambiz Ahmadi Angali Parastoo Moradi Choghakabodi Akbar Akbari Fatemeh Maghsodi Ebrahim Barzegari Maryam Jamalan Reza Aalizadeh Mostafa Jamalan |
| author_sort | Mansour Amin |
| collection | DOAJ |
| description | Objective: Given the apparent life-threatening nature of COVID-19, finding an effective treatment is under investigation.Materials and Methods: We assessed effect of shallomin oral syrup (co IranAmin®) as a complementary treatment to improve the clinical outcomes in COVID-19 patients. Patients in the control group received the approved treatment protocol (lopinavir/ritonavir), while those in the intervention group were treated with the oral syrup shallomin in addition to the approved treatment. Clinical status of treated patients was recorded and compared.Results: There were meaningful differences between the two groups regarding shortened length of hospital stay and the recovery time for cough, myalgia, sore throat, and shortness of breath. No side effect occurred in the intervention group compared to the control group in terms of biochemical and hematological factors.Conclusion: It seems that the treatment with shallomin syrup showed remarkable contribution to the recovery of COVID-19 induced symptoms in the patients under lopinavir/ritonavir therapy. |
| format | Article |
| id | doaj-art-3fff611b22004a59b4b2963f6e63b265 |
| institution | DOAJ |
| issn | 2228-7930 2228-7949 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj-art-3fff611b22004a59b4b2963f6e63b2652025-08-20T02:58:46ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492024-11-0114669971010.22038/ajp.2024.2452324523Examining efficacy and safety of ethyl acetate extract from Allium hirtifolium as complementary therapy in COVID-19: A randomized, multicenter, controlled clinical trialMansour Amin0Mandana Pouladzadeh1Mohammad Jaafar Yadyad2Roshanak Roshanfard3Mohamad Hasan Pipelzadeh4Afshin Talebi5Behzad Sharif Maakhmalzadeh6Mehdi Bijanzadeh7Nasrin Rakipour8Gholamreza Alizadehattar9Seyed Saeed Seyedian10Kambiz Ahmadi Angali11Parastoo Moradi Choghakabodi12Akbar Akbari13Fatemeh Maghsodi14Ebrahim Barzegari15Maryam Jamalan16Reza Aalizadeh17Mostafa Jamalan18Department of Microbiology, Infection and Tropical Diseases Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Emergency Medicine, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Infectious Diseases, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Microbiology, Infection and Tropical Diseases Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Pharmacology and Toxicology Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Internal Medicine, School of Medicine, Razi Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranNanotechnology Research Center, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Microbiology, Infection and Tropical Diseases Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Internal Medicine, School of Medicine, Razi Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Internal Medicine, School of Medicine, Razi Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Microbiology, Infection and Tropical Diseases Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Biochemistry, Faculty of Medicine, Abadan University of Medical Sciences, Abadan, IranDepartment of Biochemistry, Faculty of Medicine, Abadan University of Medical Sciences, Abadan, IranMedical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Microbiology and Immunology, School of Medicine, Kashan University of Medical Sciences, Kashan, IranDepartment of Biochemistry, Faculty of Biological Science, Tarbiat Modares University, Tehran, IranDepartment of Biochemistry, Faculty of Medicine, Abadan University of Medical Sciences, Abadan, IranObjective: Given the apparent life-threatening nature of COVID-19, finding an effective treatment is under investigation.Materials and Methods: We assessed effect of shallomin oral syrup (co IranAmin®) as a complementary treatment to improve the clinical outcomes in COVID-19 patients. Patients in the control group received the approved treatment protocol (lopinavir/ritonavir), while those in the intervention group were treated with the oral syrup shallomin in addition to the approved treatment. Clinical status of treated patients was recorded and compared.Results: There were meaningful differences between the two groups regarding shortened length of hospital stay and the recovery time for cough, myalgia, sore throat, and shortness of breath. No side effect occurred in the intervention group compared to the control group in terms of biochemical and hematological factors.Conclusion: It seems that the treatment with shallomin syrup showed remarkable contribution to the recovery of COVID-19 induced symptoms in the patients under lopinavir/ritonavir therapy.https://ajp.mums.ac.ir/article_24523_def74760f8707a71af68e3a36582b6c5.pdfsars-cov-2covid-19, lopinavir, ritonavir, shallomin syrup, drug safety |
| spellingShingle | Mansour Amin Mandana Pouladzadeh Mohammad Jaafar Yadyad Roshanak Roshanfard Mohamad Hasan Pipelzadeh Afshin Talebi Behzad Sharif Maakhmalzadeh Mehdi Bijanzadeh Nasrin Rakipour Gholamreza Alizadehattar Seyed Saeed Seyedian Kambiz Ahmadi Angali Parastoo Moradi Choghakabodi Akbar Akbari Fatemeh Maghsodi Ebrahim Barzegari Maryam Jamalan Reza Aalizadeh Mostafa Jamalan Examining efficacy and safety of ethyl acetate extract from Allium hirtifolium as complementary therapy in COVID-19: A randomized, multicenter, controlled clinical trial Avicenna Journal of Phytomedicine sars-cov-2 covid-19, lopinavir, ritonavir, shallomin syrup, drug safety |
| title | Examining efficacy and safety of ethyl acetate extract from Allium hirtifolium as complementary therapy in COVID-19: A randomized, multicenter, controlled clinical trial |
| title_full | Examining efficacy and safety of ethyl acetate extract from Allium hirtifolium as complementary therapy in COVID-19: A randomized, multicenter, controlled clinical trial |
| title_fullStr | Examining efficacy and safety of ethyl acetate extract from Allium hirtifolium as complementary therapy in COVID-19: A randomized, multicenter, controlled clinical trial |
| title_full_unstemmed | Examining efficacy and safety of ethyl acetate extract from Allium hirtifolium as complementary therapy in COVID-19: A randomized, multicenter, controlled clinical trial |
| title_short | Examining efficacy and safety of ethyl acetate extract from Allium hirtifolium as complementary therapy in COVID-19: A randomized, multicenter, controlled clinical trial |
| title_sort | examining efficacy and safety of ethyl acetate extract from allium hirtifolium as complementary therapy in covid 19 a randomized multicenter controlled clinical trial |
| topic | sars-cov-2 covid-19, lopinavir, ritonavir, shallomin syrup, drug safety |
| url | https://ajp.mums.ac.ir/article_24523_def74760f8707a71af68e3a36582b6c5.pdf |
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