Ferroptosis and noncoding RNAs: exploring mechanisms in lung cancer treatment
Lung cancer (LC) is a highly prevalent and deadly type of cancer characterized by intricate molecular pathways that drive tumor development, metastasis, and resistance to conventional treatments. Recently, ferroptosis, a controlled mechanism of cell death instigated by iron-dependent lipid peroxidat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1522873/full |
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| author | Nadi Rostami Ravari Farzad Sadri Farzad Sadri Mohammad Ali Mahdiabadi Yaser Mohammadi Zahra Ourang Zohreh Rezaei Zohreh Rezaei |
| author_facet | Nadi Rostami Ravari Farzad Sadri Farzad Sadri Mohammad Ali Mahdiabadi Yaser Mohammadi Zahra Ourang Zohreh Rezaei Zohreh Rezaei |
| author_sort | Nadi Rostami Ravari |
| collection | DOAJ |
| description | Lung cancer (LC) is a highly prevalent and deadly type of cancer characterized by intricate molecular pathways that drive tumor development, metastasis, and resistance to conventional treatments. Recently, ferroptosis, a controlled mechanism of cell death instigated by iron-dependent lipid peroxidation, has gained attention for its role in LC progression and treatment. Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are emerging as key modulators of ferroptosis, significantly influencing LC biology. This review explores how ncRNAs control ferroptotic pathways and affect tumor growth, metastasis, and therapy resistance in LC. By understanding the dual functions of ncRNAs in both activating and inhibiting ferroptosis, we aim to uncover new therapeutic targets and strategies for LC. These insights provide a promising direction for the development of ncRNA-based treatments designed to induce ferroptosis, potentially improving therapeutic outcomes for patients with LC. |
| format | Article |
| id | doaj-art-3ffd846c2e2a46daaac0d37119a23bf5 |
| institution | OA Journals |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-3ffd846c2e2a46daaac0d37119a23bf52025-08-20T02:03:36ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-02-011310.3389/fcell.2025.15228731522873Ferroptosis and noncoding RNAs: exploring mechanisms in lung cancer treatmentNadi Rostami Ravari0Farzad Sadri1Farzad Sadri2Mohammad Ali Mahdiabadi3Yaser Mohammadi4Zahra Ourang5Zohreh Rezaei6Zohreh Rezaei7Department of Animal Science Researches, Agriculture and Natural Resources Education and Research Center of Kerman, Agriculture and Natural Resources Education and Research Organization (AREEO), Kerman, IranStudent Research Committee, Birjand University of Medical Sciences, Birjand, IranGeriatric Health Research Center, Birjand University of Medical Sciences, Birjand, IranDepartment of Internal Medicine, School of Medicine, Birjand University of Medical Sciences, Birjand, IranDepartment of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, IranDepartment of Biochemistry, School of Medicine, Arak University of Medical Sciences, Arak, IranGeriatric Health Research Center, Birjand University of Medical Sciences, Birjand, IranDepartment of Biology, University of Sistan and Baluchestan, Zahedan, IranLung cancer (LC) is a highly prevalent and deadly type of cancer characterized by intricate molecular pathways that drive tumor development, metastasis, and resistance to conventional treatments. Recently, ferroptosis, a controlled mechanism of cell death instigated by iron-dependent lipid peroxidation, has gained attention for its role in LC progression and treatment. Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are emerging as key modulators of ferroptosis, significantly influencing LC biology. This review explores how ncRNAs control ferroptotic pathways and affect tumor growth, metastasis, and therapy resistance in LC. By understanding the dual functions of ncRNAs in both activating and inhibiting ferroptosis, we aim to uncover new therapeutic targets and strategies for LC. These insights provide a promising direction for the development of ncRNA-based treatments designed to induce ferroptosis, potentially improving therapeutic outcomes for patients with LC.https://www.frontiersin.org/articles/10.3389/fcell.2025.1522873/fullferroptosislung cancernoncoding RNAstherapeutic targetsmetastasis |
| spellingShingle | Nadi Rostami Ravari Farzad Sadri Farzad Sadri Mohammad Ali Mahdiabadi Yaser Mohammadi Zahra Ourang Zohreh Rezaei Zohreh Rezaei Ferroptosis and noncoding RNAs: exploring mechanisms in lung cancer treatment Frontiers in Cell and Developmental Biology ferroptosis lung cancer noncoding RNAs therapeutic targets metastasis |
| title | Ferroptosis and noncoding RNAs: exploring mechanisms in lung cancer treatment |
| title_full | Ferroptosis and noncoding RNAs: exploring mechanisms in lung cancer treatment |
| title_fullStr | Ferroptosis and noncoding RNAs: exploring mechanisms in lung cancer treatment |
| title_full_unstemmed | Ferroptosis and noncoding RNAs: exploring mechanisms in lung cancer treatment |
| title_short | Ferroptosis and noncoding RNAs: exploring mechanisms in lung cancer treatment |
| title_sort | ferroptosis and noncoding rnas exploring mechanisms in lung cancer treatment |
| topic | ferroptosis lung cancer noncoding RNAs therapeutic targets metastasis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1522873/full |
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