INFLUENCE OF CORTISOL AND VERY LOW-DENSITY LIPOPROTEINES ON THE DEVELOPMENT OF HA-1HEPATOMA AND EHRLICH’S CARCINOMA
Studies were conducted using ascetic HA-1 hepatomas and ascitic Ehrlich’s carcinoma cells. After passage of cells in mice, cell culture containing tumor-associated macrophages was studied. It was shown that the very low-density lipoprotein (VLDL)-cortisol complex significantly inhibited proliferativ...
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| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/129 |
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| author | L. E. Panin Zh. I. Belonogova R. A. Knyazev I. O. Cheshenko |
| author_facet | L. E. Panin Zh. I. Belonogova R. A. Knyazev I. O. Cheshenko |
| author_sort | L. E. Panin |
| collection | DOAJ |
| description | Studies were conducted using ascetic HA-1 hepatomas and ascitic Ehrlich’s carcinoma cells. After passage of cells in mice, cell culture containing tumor-associated macrophages was studied. It was shown that the very low-density lipoprotein (VLDL)-cortisol complex significantly inhibited proliferative activity of tumor cells. The obtained constant of cortisol binding to VLDL indicated that the protein component of lipoproteins participated in the complex formation. Tumor-associated macrophages were suggested to play an important role in the formation of this complex. It was found that inhibition of tumor cell growth was related to apoptosis. |
| format | Article |
| id | doaj-art-3ff90b75178f4723a257bc0a61a4d495 |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-3ff90b75178f4723a257bc0a61a4d4952025-08-20T02:59:11ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01034346129INFLUENCE OF CORTISOL AND VERY LOW-DENSITY LIPOPROTEINES ON THE DEVELOPMENT OF HA-1HEPATOMA AND EHRLICH’S CARCINOMAL. E. Panin0Zh. I. Belonogova1R. A. Knyazev2I. O. Cheshenko3Research Institute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences, NovosibirskResearch Institute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences, NovosibirskResearch Institute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences, NovosibirskResearch Institute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences, NovosibirskStudies were conducted using ascetic HA-1 hepatomas and ascitic Ehrlich’s carcinoma cells. After passage of cells in mice, cell culture containing tumor-associated macrophages was studied. It was shown that the very low-density lipoprotein (VLDL)-cortisol complex significantly inhibited proliferative activity of tumor cells. The obtained constant of cortisol binding to VLDL indicated that the protein component of lipoproteins participated in the complex formation. Tumor-associated macrophages were suggested to play an important role in the formation of this complex. It was found that inhibition of tumor cell growth was related to apoptosis.https://www.siboncoj.ru/jour/article/view/129tumor cellslipoproteinscortisoltumor-associated macrophagesbiosynthesis of nucleic acid |
| spellingShingle | L. E. Panin Zh. I. Belonogova R. A. Knyazev I. O. Cheshenko INFLUENCE OF CORTISOL AND VERY LOW-DENSITY LIPOPROTEINES ON THE DEVELOPMENT OF HA-1HEPATOMA AND EHRLICH’S CARCINOMA Сибирский онкологический журнал tumor cells lipoproteins cortisol tumor-associated macrophages biosynthesis of nucleic acid |
| title | INFLUENCE OF CORTISOL AND VERY LOW-DENSITY LIPOPROTEINES ON THE DEVELOPMENT OF HA-1HEPATOMA AND EHRLICH’S CARCINOMA |
| title_full | INFLUENCE OF CORTISOL AND VERY LOW-DENSITY LIPOPROTEINES ON THE DEVELOPMENT OF HA-1HEPATOMA AND EHRLICH’S CARCINOMA |
| title_fullStr | INFLUENCE OF CORTISOL AND VERY LOW-DENSITY LIPOPROTEINES ON THE DEVELOPMENT OF HA-1HEPATOMA AND EHRLICH’S CARCINOMA |
| title_full_unstemmed | INFLUENCE OF CORTISOL AND VERY LOW-DENSITY LIPOPROTEINES ON THE DEVELOPMENT OF HA-1HEPATOMA AND EHRLICH’S CARCINOMA |
| title_short | INFLUENCE OF CORTISOL AND VERY LOW-DENSITY LIPOPROTEINES ON THE DEVELOPMENT OF HA-1HEPATOMA AND EHRLICH’S CARCINOMA |
| title_sort | influence of cortisol and very low density lipoproteines on the development of ha 1hepatoma and ehrlich s carcinoma |
| topic | tumor cells lipoproteins cortisol tumor-associated macrophages biosynthesis of nucleic acid |
| url | https://www.siboncoj.ru/jour/article/view/129 |
| work_keys_str_mv | AT lepanin influenceofcortisolandverylowdensitylipoproteinesonthedevelopmentofha1hepatomaandehrlichscarcinoma AT zhibelonogova influenceofcortisolandverylowdensitylipoproteinesonthedevelopmentofha1hepatomaandehrlichscarcinoma AT raknyazev influenceofcortisolandverylowdensitylipoproteinesonthedevelopmentofha1hepatomaandehrlichscarcinoma AT iocheshenko influenceofcortisolandverylowdensitylipoproteinesonthedevelopmentofha1hepatomaandehrlichscarcinoma |