Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental Study
Background/Objective. Cisplatin is a widely used chemotherapeutic agent, but its ototoxicity side effect can occur in the majority of patients. Lots of agents were tried to prevent this, but there is not a routine treatment modality yet. The aim of this study was to evaluate the otoprotective effect...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/523480 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545426875613184 |
|---|---|
| author | Murat Ozturk Selcuk Ucar Fatih Sarı Selvet Erdogan Murat Topdag Mete Iseri |
| author_facet | Murat Ozturk Selcuk Ucar Fatih Sarı Selvet Erdogan Murat Topdag Mete Iseri |
| author_sort | Murat Ozturk |
| collection | DOAJ |
| description | Background/Objective. Cisplatin is a widely used chemotherapeutic agent, but its ototoxicity side effect can occur in the majority of patients. Lots of agents were tried to prevent this, but there is not a routine treatment modality yet. The aim of this study was to evaluate the otoprotective effect of sertraline, which is an antidepressant with neuroprotective effects, against cisplatin, in rats. Design. Experimental animal study. Material and Methods. Forty-eight rats were randomly separated in two groups as groups I and II. Group I was identified as the control group and only a single dose of intraperitoneal cisplatin was administered. In group II, in addition to cisplatin, sertraline was administered to the rats through an oral cannula for ten-day period. Distortion product otoacoustic emission measurements were performed at the first day and the 10th day. Results. When the ototoxicity rates after cisplatin in group I and group II in distortion product otoacoustic emission measurements were compared, it was statistically significantly lower in group II in frequencies of 5652, 6165, 6726, 7336, and 7996 Hz (). Conclusion. Sertraline seems to have a protective effect on cisplatin ototoxicity and could be used to prevent the ototoxicity and also to treat the depression that occurred in cancer patients together. |
| format | Article |
| id | doaj-art-3ff7b18e761f498a93401e7d3d53999f |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-3ff7b18e761f498a93401e7d3d53999f2025-02-03T07:25:43ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/523480523480Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental StudyMurat Ozturk0Selcuk Ucar1Fatih Sarı2Selvet Erdogan3Murat Topdag4Mete Iseri5Department of Otolaryngology, Kocaeli University, Faculty of Medicine, 41380 Kocaeli, TurkeyDepartment of Otolaryngology, Kocaeli University, Faculty of Medicine, 41380 Kocaeli, TurkeyDepartment of Otolaryngology, Kocaeli University, Faculty of Medicine, 41380 Kocaeli, TurkeyDepartment of Otolaryngology, Kocaeli University, Faculty of Medicine, 41380 Kocaeli, TurkeyDepartment of Otolaryngology, Kocaeli University, Faculty of Medicine, 41380 Kocaeli, TurkeyDepartment of Otolaryngology, Kocaeli University, Faculty of Medicine, 41380 Kocaeli, TurkeyBackground/Objective. Cisplatin is a widely used chemotherapeutic agent, but its ototoxicity side effect can occur in the majority of patients. Lots of agents were tried to prevent this, but there is not a routine treatment modality yet. The aim of this study was to evaluate the otoprotective effect of sertraline, which is an antidepressant with neuroprotective effects, against cisplatin, in rats. Design. Experimental animal study. Material and Methods. Forty-eight rats were randomly separated in two groups as groups I and II. Group I was identified as the control group and only a single dose of intraperitoneal cisplatin was administered. In group II, in addition to cisplatin, sertraline was administered to the rats through an oral cannula for ten-day period. Distortion product otoacoustic emission measurements were performed at the first day and the 10th day. Results. When the ototoxicity rates after cisplatin in group I and group II in distortion product otoacoustic emission measurements were compared, it was statistically significantly lower in group II in frequencies of 5652, 6165, 6726, 7336, and 7996 Hz (). Conclusion. Sertraline seems to have a protective effect on cisplatin ototoxicity and could be used to prevent the ototoxicity and also to treat the depression that occurred in cancer patients together.http://dx.doi.org/10.1155/2013/523480 |
| spellingShingle | Murat Ozturk Selcuk Ucar Fatih Sarı Selvet Erdogan Murat Topdag Mete Iseri Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental Study The Scientific World Journal |
| title | Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental Study |
| title_full | Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental Study |
| title_fullStr | Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental Study |
| title_full_unstemmed | Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental Study |
| title_short | Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental Study |
| title_sort | possible protective effect of sertraline against cisplatin induced ototoxicity an experimental study |
| url | http://dx.doi.org/10.1155/2013/523480 |
| work_keys_str_mv | AT muratozturk possibleprotectiveeffectofsertralineagainstcisplatininducedototoxicityanexperimentalstudy AT selcukucar possibleprotectiveeffectofsertralineagainstcisplatininducedototoxicityanexperimentalstudy AT fatihsarı possibleprotectiveeffectofsertralineagainstcisplatininducedototoxicityanexperimentalstudy AT selveterdogan possibleprotectiveeffectofsertralineagainstcisplatininducedototoxicityanexperimentalstudy AT murattopdag possibleprotectiveeffectofsertralineagainstcisplatininducedototoxicityanexperimentalstudy AT meteiseri possibleprotectiveeffectofsertralineagainstcisplatininducedototoxicityanexperimentalstudy |