Isoliquiritigenin Promotes the Repair of High Uric Acid‐Induced Vascular Injuries
ABSTRACT Hyperuricemia (HUA) is a chronic metabolic disease mainly stemming from purine metabolism disorders and strongly correlated with cardiovascular diseases, gout, chronic kidney disease, and other diseases. Elevated levels of uric acid (UA) in serum will lead to vascular endothelial cell injur...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-06-01
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| Series: | Smart Medicine |
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| Online Access: | https://doi.org/10.1002/smmd.70000 |
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| author | Hongyan Zhou Xinyu Song Yingying Tian Lili Zhao Jingyi Yang Fangfu Ye Ting Cao Jiayu Zhang |
| author_facet | Hongyan Zhou Xinyu Song Yingying Tian Lili Zhao Jingyi Yang Fangfu Ye Ting Cao Jiayu Zhang |
| author_sort | Hongyan Zhou |
| collection | DOAJ |
| description | ABSTRACT Hyperuricemia (HUA) is a chronic metabolic disease mainly stemming from purine metabolism disorders and strongly correlated with cardiovascular diseases, gout, chronic kidney disease, and other diseases. Elevated levels of uric acid (UA) in serum will lead to vascular endothelial cell injuries directly, subsequently impairing normal functions of human blood vessels. Therefore, investigating endothelial cell injuries resulting from HUA and corresponding drug screening for its treatment are of great significance in the prevention and treatment of vascular diseases. Given the inherent advantages of multiple targets and pathways, we delved into the potential of traditional Chinese medicine in alleviating vascular injuries induced by HUA in detail. Through the establishment of an injury index library and subsequent drug screening process, isoliquiritigenin proved to be a promising candidate for promoting the repair of HUA‐induced vascular injuries. It had been identified, validated and its efficiency evaluated using blood vessel‐on‐a‐chip and animal tests. Additionally, network pharmacology and molecular docking were further employed to elucidate the underlying mechanism. This work represents the first demonstration of isoliquiritigenin's capacity to facilitate the repair of vascular injuries triggered by high UA levels, and provides valuable insights for the treatment of HUA using traditional Chinese medicine. |
| format | Article |
| id | doaj-art-3ff7aacecda241ccb752d7a6bb512ad1 |
| institution | OA Journals |
| issn | 2751-1871 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Smart Medicine |
| spelling | doaj-art-3ff7aacecda241ccb752d7a6bb512ad12025-08-20T02:22:02ZengWiley-VCHSmart Medicine2751-18712025-06-0142n/an/a10.1002/smmd.70000Isoliquiritigenin Promotes the Repair of High Uric Acid‐Induced Vascular InjuriesHongyan Zhou0Xinyu Song1Yingying Tian2Lili Zhao3Jingyi Yang4Fangfu Ye5Ting Cao6Jiayu Zhang7School of Traditional Chinese Medicine Binzhou Medical University Yantai Shandong ChinaThe Second School of Clinical Medicine Binzhou Medical University Yantai ChinaSchool of Traditional Chinese Medicine Binzhou Medical University Yantai Shandong ChinaSchool of Traditional Chinese Medicine Binzhou Medical University Yantai Shandong ChinaSchool of Traditional Chinese Medicine Binzhou Medical University Yantai Shandong ChinaBeijing National Laboratory for Condensed Matter Physics and Laboratory of Soft Matter Physics Institute of Physics Chinese Academy of Sciences Beijing ChinaBeijing National Laboratory for Condensed Matter Physics and Laboratory of Soft Matter Physics Institute of Physics Chinese Academy of Sciences Beijing ChinaSchool of Traditional Chinese Medicine Binzhou Medical University Yantai Shandong ChinaABSTRACT Hyperuricemia (HUA) is a chronic metabolic disease mainly stemming from purine metabolism disorders and strongly correlated with cardiovascular diseases, gout, chronic kidney disease, and other diseases. Elevated levels of uric acid (UA) in serum will lead to vascular endothelial cell injuries directly, subsequently impairing normal functions of human blood vessels. Therefore, investigating endothelial cell injuries resulting from HUA and corresponding drug screening for its treatment are of great significance in the prevention and treatment of vascular diseases. Given the inherent advantages of multiple targets and pathways, we delved into the potential of traditional Chinese medicine in alleviating vascular injuries induced by HUA in detail. Through the establishment of an injury index library and subsequent drug screening process, isoliquiritigenin proved to be a promising candidate for promoting the repair of HUA‐induced vascular injuries. It had been identified, validated and its efficiency evaluated using blood vessel‐on‐a‐chip and animal tests. Additionally, network pharmacology and molecular docking were further employed to elucidate the underlying mechanism. This work represents the first demonstration of isoliquiritigenin's capacity to facilitate the repair of vascular injuries triggered by high UA levels, and provides valuable insights for the treatment of HUA using traditional Chinese medicine.https://doi.org/10.1002/smmd.70000animal testblood vessel‐on‐a‐chiphyperuricemia (HUA)isoliquiritigeninvascular endothelial injury |
| spellingShingle | Hongyan Zhou Xinyu Song Yingying Tian Lili Zhao Jingyi Yang Fangfu Ye Ting Cao Jiayu Zhang Isoliquiritigenin Promotes the Repair of High Uric Acid‐Induced Vascular Injuries Smart Medicine animal test blood vessel‐on‐a‐chip hyperuricemia (HUA) isoliquiritigenin vascular endothelial injury |
| title | Isoliquiritigenin Promotes the Repair of High Uric Acid‐Induced Vascular Injuries |
| title_full | Isoliquiritigenin Promotes the Repair of High Uric Acid‐Induced Vascular Injuries |
| title_fullStr | Isoliquiritigenin Promotes the Repair of High Uric Acid‐Induced Vascular Injuries |
| title_full_unstemmed | Isoliquiritigenin Promotes the Repair of High Uric Acid‐Induced Vascular Injuries |
| title_short | Isoliquiritigenin Promotes the Repair of High Uric Acid‐Induced Vascular Injuries |
| title_sort | isoliquiritigenin promotes the repair of high uric acid induced vascular injuries |
| topic | animal test blood vessel‐on‐a‐chip hyperuricemia (HUA) isoliquiritigenin vascular endothelial injury |
| url | https://doi.org/10.1002/smmd.70000 |
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