Global, regional, and national burden of tobacco-related neurological disorders from 1990 to 2021: Trends and future projections
Introduction Tobacco use is as a major public health concern around the world, adversely impacting quality of life. Our study aims to analyze the trends in the burden of tobacco-related neurological disorders (ND) at global, regional, and national levels from 1990 to 2021, as well as potential futur...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2025-03-01
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| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | https://www.tobaccoinduceddiseases.org/Global-regional-and-national-burden-of-tobacco-related-neurological-disorders-from,201966,0,2.html |
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| Summary: | Introduction
Tobacco use is as a major public health concern around the world,
adversely impacting quality of life. Our study aims to analyze the trends in the
burden of tobacco-related neurological disorders (ND) at global, regional, and
national levels from 1990 to 2021, as well as potential future trends.
Methods
We performed a secondary dataset analysis for the assessment of mortality
and disability-adjusted life years (DALYs) using data from the Global Burden of
Diseases, Injuries, and Risk Factors Study (GBD) 2021, to explore the burden of
tobacco-related ND. We also analyzed the associations between the burden of ND
and factors such as age, gender, and the Sociodemographic Index (SDI).
Results
In 2021, the age-standardized mortality rate (ASMR) and age-standardized
DALYs rate (ASDR) for neurological disorders were 0.50 per 100000 persons
(95% UI: -0.15–1.98) and 11.25 per 100000 persons (95% UI: 1.36–34.36),
respectively. Alzheimer’s disease and other dementias (ADOD) had a particularly
significant impact on the burden of ND. However, the ASDR for Parkinson’s
disease was -8.38 per 100000 persons (95% UI: -10.72 – -6.20). The burden of
disease was greater in men and older people, with substantial regional variation.
While aging and population growth might contribute to the increase in DALYs
for tobacco-related ND, epidemiological changes have the potential to reduce
the burden. From 2022 to 2050, the BAPC model predicted a decline in the agestandardized
rate (ASR) of DALYs and mortality for tobacco-related ND, globally.
Conclusions
Tobacco use increased the burden of ND such as ADOD and multiple
sclerosis (MS), while reducing the burden of Parkinson’s disease (PD). The
burden of disease was disproportionately higher among older individuals and
males, with significant disparities across nations and regions. Over the past 32
years, the burden of these diseases has gradually decreased, and this trend is
expected to continue from 2022 to 2050. |
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| ISSN: | 1617-9625 |