5-Fluorouracil-β-Cyclodextrin conjugates:Linker strategies to enhance the anticancer efficacy and reduce the side effects

5-Fluorouracil-β-Cyclodextrin conjugates:Linker strategies to enhance the anticancer efficacy and reduce the side effects

5-Fluorouracil (5-FU) serves as a first-line therapeutic agent for colorectal cancer, however, its utility is limited by a short half-life and significant cytotoxicity. This study focused on the construction of 5-Fluorouracil-β-Cyclodextrin polymers (5-FUSA-β-CD and 5-FUBA-β-CD) by covalent conjugat...

Full description

Saved in:

Bibliographic Details
Main Authors:	Liangliang Hu, Ting Meng, Davies Marabada, Zhichao Jin, Qing Huang, Shijie Wei, Zhizhong Wang
Format:	Article
Language:	English
Published:	Elsevier 2025-03-01
Series:	Carbohydrate Polymer Technologies and Applications
Subjects:	5-fluorouracil Conjugates Linker;β-cyclodextrin Antitumor activity Cytotoxicity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666893925000301
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Optimizing ibrutinib bioavailability: Formulation and assessment of hydroxypropyl-β-cyclodextrin-based nanosponge delivery systems
by: Sunitha Sampathi, et al.
Published: (2025-01-01)

Exploring the efficacy of fluorouracil and platinum based chemotherapy in advanced hepatocellular carcinoma to bridge the treatment gap in resource limited settings
by: Se Jun Park, et al.
Published: (2025-01-01)

Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes
by: Zongheng Wang, et al.
Published: (2025-01-01)

Cyclodextrins’ Internal Cavity Hydration: Insights from Theory and Experiment
by: Silvia Angelova, et al.
Published: (2025-01-01)

Unlocking Dabrafenib’s Potential: A Quality by Design (QBD) Journey to Enhance Permeation and Oral Bioavailability through Nanosponge Formulation
by: Konda Sri Chaya Reddy, et al.
Published: (2025-01-01)

Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusion
by: Mehmet Erdem Çakmak, et al.
Published: (2024-08-01)

Directly Gel‐Thermal Processing of Linker‐Mixed Crystal‐Glass Composite Membranes for Sorption‐Preferential Gas Separation
by: Yihao Xiao, et al.
Published: (2025-02-01)

Risk factors for fluorouracil-induced cardiotoxicity in patients with gastrointestinal tumor
by: Yuting Wu, et al.
Published: (2025-02-01)

Inactivation of Zika Virus with Hydroxypropyl-Beta-Cyclodextrin
by: Cory R. Hewitt, et al.
Published: (2025-01-01)

Native Cyclodextrin-Based Metal–Organic Frameworks (MOFs): Synthesis, Characterization, and Potential Applications in Food Industry
by: Siddanth Saxena, et al.
Published: (2025-01-01)

Utilizing sc-linker to integrate single-cell RNA sequencing and human genetics to identify cell types and driver genes associated with non-small cell lung cancer
by: Yangfan Zhou, et al.
Published: (2025-01-01)

C-28 linker length modulates the activity of second-generation HIV-1 maturation inhibitors
by: K. C. Yuvraj, et al.
Published: (2025-01-01)

Determination of 5-fluorouracil anticancer drug solubility in supercritical CO 2 using semi-empirical and machine learning models
by: Gholamhossein Sodeifian, et al.
Published: (2025-02-01)

Polymer-Free Electrospinning of β-Cyclodextrin–Oligolactide for Magnolol and Honokiol Pharmaceutical Formulations
by: Diana-Andreea Blaj, et al.
Published: (2025-01-01)

Complexation of Z-ligustilide with hydroxypropyl-β-cyclodextrin to improve stability and oral bioavailability
by: Lu Yapeng, et al.
Published: (2014-06-01)

A superior preparation method for daidzein-hydroxypropyl-β-cyclodextrin complexes with improved solubility and dissolution: Supercritical fluid process
by: Pan Hao, et al.
Published: (2017-03-01)

Comparative Efficacy and Tolerability of Imiquimod 3.75% Cream vs 5-Fluorouracil 4% cream in the Treatment of Actinic Keratosis: A Split-Face Study
by: Cesare Ariasi, et al.
Published: (2025-01-01)

Repetitive stability study of remdesivir/cyclodextrin complex on the international space station
by: György Dormán, et al.
Published: (2025-02-01)

Synergistic Antibacterial Action of Norfloxacin-Encapsulated G4 Hydrogels: The Role of Boronic Acid and Cyclodextrin
by: Monica-Cornelia Sardaru, et al.
Published: (2025-01-01)

Ionophore-based potentiometric PVC membrane sensors for determination of phenobarbitone in pharmaceutical formulations
by: Alrabiah Haitham, et al.
Published: (2016-12-01)

Women's experiences and acceptability of self-administered, home delivered, intravaginal 5-Fluorouracil cream for cervical precancer treatment in Kenya
by: Konyin Adewumi, et al.
Published: (2025-02-01)

AN EXAMINATION OF CONJUGATIONAL SUFFIXES OF PASSIVE CONSTRUCTIONS IN FULFULDE
by: YAHAYA MOHAMMED AHMED
Published: (2024-07-01)

Is the benefit of sequential 5-fluorouracil and daylight photodynamic therapy versus daylight photodynamic therapy alone sustained over time? – 12-month follow-up of a randomized controlled trial
by: Stine Regin Wiegell, et al.
Published: (2025-02-01)

Anticancer potential of coumarins from the Ferulago genus
by: Mansour Mofasseri, et al.
Published: (2025-01-01)

Comparative Analysis of γ-Cyclodextrin, Perilla Oil, and Their Inclusion Complexes on Liver Injury and Dyslipidemia Associated with Elevated Gastrointestinal 12-Hydroxylated Bile Acid Levels
by: Keisuke Yoshikiyo, et al.
Published: (2025-01-01)

VIOLÊNCIA CONJUGAL ASSOCIADA AO USO ABUSIVO DE ÁLCOOL: UMA REVISÃO SISTEMÁTICA INTEGRATIVA
by: Eduardo Jorge Sant'Ana Honorato, et al.
Published: (2019-06-01)

Current issues with antibody-conjugated lipid nanoparticles
by: Aayush
Published: (2025-02-01)

Theoretical statements for synthesis of conjugate couplings
by: P. D. Balakin, et al.
Published: (2020-12-01)

5 Fluorouracil‐loaded biosynthesised gold nanoparticles for the in vitro treatment of human pancreatic cancer cell
by: Senthil Kumar Chinnaiyan, et al.
Published: (2019-10-01)

Cytotoxic Activity of Polymethoxyflavone Compounds Ethyl Acetate Extract of Sungkai Leaves (Peronema canescens Jack) as Anticancer Candidates
by: Zairaini Adriliana Adriliana, et al.
Published: (2022-12-01)

Encapsulation of Vecuronium and Rocuronium by Sugammadex Investigated by Surface-Enhanced Raman Spectroscopy
by: Adriana Kenđel, et al.
Published: (2025-01-01)

Phenotypic and genotypic features of the full-term newborns with delayed conjugation jaundices in relation to gender of the child
by: O. K. Botvin'yev, et al.
Published: (2013-12-01)

Peptide Aptamer–Paclitaxel Conjugates for Tumor Targeted Therapy
by: Xinyang Shen, et al.
Published: (2024-12-01)

Study on the regulatory mechanisms of mitochondrial biosynthesis by polyoxometalates
by: Shan Lei, et al.
Published: (2025-03-01)

Production and Application of Lysozyme-Gum Arabic Conjugate in Mayonnaise as a Natural Preservative and Emulsifier
by: Hashemi Marjan M., et al.
Published: (2018-03-01)

Microplastics mediates the spread of antimicrobial resistance plasmids via modulating conjugal gene expression
by: Qiu E. Yang, et al.
Published: (2025-01-01)

An efficient modified HS conjugate gradient algorithm in machine learning
by: Gonglin Yuan, et al.
Published: (2024-11-01)

Exploring the anticancer potential of Hewittia malabarica through phytochemical analysis and molecular docking study
by: Shiji Thozhukkad Moosaripparambil, et al.
Published: (2025-02-01)

Nevoid basal cell carcinoma syndrome (Gorlin syndrome): a case report
by: Noura Abdul Rahman, et al.
Published: (2025-01-01)

The anticancer properties, cell-cycle cytotoxicity and apoptosis of cissus rotundifolia, trema orientalis, and buddleja polystachya with ocular applications
by: Ali Hendi Alghamdi, et al.
Published: (2025-02-01)