Immunogenicity dynamics and covariate effects after satralizumab administration predicted with a hidden Markov model
Abstract Immunogenicity is the propensity of a therapeutic protein to generate an immune response to itself. While reporting of antidrug antibodies (ADAs) is increasing, model‐based analysis of such data is seldom performed. Model‐based characterization of factors affecting the emergence and dissipa...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-12-01
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| Series: | CPT: Pharmacometrics & Systems Pharmacology |
| Online Access: | https://doi.org/10.1002/psp4.13230 |
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