C-reactive protein conformations and their association with the IL-1β/IL-6 pathway in ocular inflammatory conditions

C-reactive protein conformations and their association with the IL-1β/IL-6 pathway in ocular inflammatory conditions

IntroductionC-reactive protein (CRP) plays a critical role in the innate immune system and serves as a biomarker for various inflammatory conditions. CRP is a dynamic protein undergoing conformational changes between pentameric (pCRP) and monomeric (mCRP) conformations. pCRP is the well-established...

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Bibliographic Details
Main Authors: Mercedes S. Nabaes Jodar, Víctor Llorenç, Marc Figueras-Roca, Maite Sainz de-la-Maza, Alfredo Adán, Blanca Molins
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
C-reactive protein (CRP)
interleukin-1β (IL-1β)
interleukin-6 (IL-6)
ocular inflammation
uveitis
diabetic macular edema
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1601145/full
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