The Relationship Between Serum Levels of Thyroglobulin Antibody and the Risk of Recurrence in Patients With Differentiated Thyroid Cancer
ABSTRACT Objective Thyroid Autoantibodies (TgAbs) are associated with autoimmune thyroid disorders and are also used in thyroid cancer follow‐up to monitor for recurrence of disease. This study aimed to explore the potential utility of TgAbs as a surrogate tumor marker and examine the relationship b...
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Wiley
2025-05-01
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| Online Access: | https://doi.org/10.1002/cnr2.70191 |
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| author | Amirian Fatemeh Yaghoubi Mohammad Ali Mehrad‐Majd Hassan Mohebbi Masoud Layegh Parvin Vazifeh‐Mostaan Leila Dadgar Moghaddam Maliheh Amirian Zahra Taghavi Ghazaleh |
| author_facet | Amirian Fatemeh Yaghoubi Mohammad Ali Mehrad‐Majd Hassan Mohebbi Masoud Layegh Parvin Vazifeh‐Mostaan Leila Dadgar Moghaddam Maliheh Amirian Zahra Taghavi Ghazaleh |
| author_sort | Amirian Fatemeh |
| collection | DOAJ |
| description | ABSTRACT Objective Thyroid Autoantibodies (TgAbs) are associated with autoimmune thyroid disorders and are also used in thyroid cancer follow‐up to monitor for recurrence of disease. This study aimed to explore the potential utility of TgAbs as a surrogate tumor marker and examine the relationship between fluctuations in TgAbs levels and disease recurrence in patients with Differentiated Thyroid Cancer (DTC). Methods This cohort study was conducted on a sample of 97 patients who underwent thyroidectomy for differentiated thyroid cancer (DTC) between the years 2017 and 2021. Following surgery (with or without lymph node dissection), levothyroxine therapy and 131 iodine were prescribed (as necessary). Regular laboratory evaluations were conducted, which involved measuring Tg and TgAb at 3 and 6 months postoperatively. Patients were classified based on recurrence rate and different levels of TgAb, and ROC analysis was applied. All data were analyzed with SPSS24, and a p‐value < 0.05 was considered statistically significant. Results For low‐risk patients, TgAb trends over time showed an increase at 6 months, while for high‐risk patients, TgAb levels continuously rose starting from 3 months. Although TgAb levels above the functional sensitivity threshold did not predict recurrence overall, changes in TgAb levels at 6 months compared to 3 months after surgery were indicative of recurrence. Conclusion In the entire population, having TgAb levels higher than the functional sensitivity threshold had no risk of various relapses. However, changes in TgAb serum levels at 6 months after surgery, compared to 3 months after surgery, can serve as an indication of tumor recurrence. |
| format | Article |
| id | doaj-art-3fefde4eb9d74482926d0748d62f24e0 |
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| issn | 2573-8348 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
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| series | Cancer Reports |
| spelling | doaj-art-3fefde4eb9d74482926d0748d62f24e02025-08-20T02:38:23ZengWileyCancer Reports2573-83482025-05-0185n/an/a10.1002/cnr2.70191The Relationship Between Serum Levels of Thyroglobulin Antibody and the Risk of Recurrence in Patients With Differentiated Thyroid CancerAmirian Fatemeh0Yaghoubi Mohammad Ali1Mehrad‐Majd Hassan2Mohebbi Masoud3Layegh Parvin4Vazifeh‐Mostaan Leila5Dadgar Moghaddam Maliheh6Amirian Zahra7Taghavi Ghazaleh8Faculty of Medicine, Department of Internal Medicine Mashhad University of Medical Sciences Mashhad IranMetabolic Syndrome Research Center Mashhad University of Medical Sciences Mashhad IranCancer Molecular Pathology Research Center Mashhad University of Medical Sciences Mashhad IranEndocrine Research Center Mashhad University of Medical Sciences Mashhad IranEndocrinology & Metabolism Member of Metabolic Syndrome Research Center (MSRC) Mashhad University of Medical Sciences Mashhad IranMashhad University of Medical Sciences Mashhad IranCommunity Medicine, Community Medicine Department School of Medicine Mashhad IranUniversity of Medicine, Trauma and General Surgery Wards, Imam Ali Hospital Zahedan IranMashhad University of Medical Sciences Mashhad IranABSTRACT Objective Thyroid Autoantibodies (TgAbs) are associated with autoimmune thyroid disorders and are also used in thyroid cancer follow‐up to monitor for recurrence of disease. This study aimed to explore the potential utility of TgAbs as a surrogate tumor marker and examine the relationship between fluctuations in TgAbs levels and disease recurrence in patients with Differentiated Thyroid Cancer (DTC). Methods This cohort study was conducted on a sample of 97 patients who underwent thyroidectomy for differentiated thyroid cancer (DTC) between the years 2017 and 2021. Following surgery (with or without lymph node dissection), levothyroxine therapy and 131 iodine were prescribed (as necessary). Regular laboratory evaluations were conducted, which involved measuring Tg and TgAb at 3 and 6 months postoperatively. Patients were classified based on recurrence rate and different levels of TgAb, and ROC analysis was applied. All data were analyzed with SPSS24, and a p‐value < 0.05 was considered statistically significant. Results For low‐risk patients, TgAb trends over time showed an increase at 6 months, while for high‐risk patients, TgAb levels continuously rose starting from 3 months. Although TgAb levels above the functional sensitivity threshold did not predict recurrence overall, changes in TgAb levels at 6 months compared to 3 months after surgery were indicative of recurrence. Conclusion In the entire population, having TgAb levels higher than the functional sensitivity threshold had no risk of various relapses. However, changes in TgAb serum levels at 6 months after surgery, compared to 3 months after surgery, can serve as an indication of tumor recurrence.https://doi.org/10.1002/cnr2.70191differented thyroid cancerTg Abthyroid cancer |
| spellingShingle | Amirian Fatemeh Yaghoubi Mohammad Ali Mehrad‐Majd Hassan Mohebbi Masoud Layegh Parvin Vazifeh‐Mostaan Leila Dadgar Moghaddam Maliheh Amirian Zahra Taghavi Ghazaleh The Relationship Between Serum Levels of Thyroglobulin Antibody and the Risk of Recurrence in Patients With Differentiated Thyroid Cancer Cancer Reports differented thyroid cancer Tg Ab thyroid cancer |
| title | The Relationship Between Serum Levels of Thyroglobulin Antibody and the Risk of Recurrence in Patients With Differentiated Thyroid Cancer |
| title_full | The Relationship Between Serum Levels of Thyroglobulin Antibody and the Risk of Recurrence in Patients With Differentiated Thyroid Cancer |
| title_fullStr | The Relationship Between Serum Levels of Thyroglobulin Antibody and the Risk of Recurrence in Patients With Differentiated Thyroid Cancer |
| title_full_unstemmed | The Relationship Between Serum Levels of Thyroglobulin Antibody and the Risk of Recurrence in Patients With Differentiated Thyroid Cancer |
| title_short | The Relationship Between Serum Levels of Thyroglobulin Antibody and the Risk of Recurrence in Patients With Differentiated Thyroid Cancer |
| title_sort | relationship between serum levels of thyroglobulin antibody and the risk of recurrence in patients with differentiated thyroid cancer |
| topic | differented thyroid cancer Tg Ab thyroid cancer |
| url | https://doi.org/10.1002/cnr2.70191 |
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