The role of exogenous histamine in atopic dermatitis flare-ups
Atopic dermatitis (AD) remains a significant challenge due to its chronic and relapsing nature, with various triggers exacerbating symptoms. While endogenous histamine’s role in AD is well documented, the impact of exogenous histamine remains controversial. This review explores the complex relations...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2024-08-01
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| Series: | Alergologia Polska |
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| Online Access: | https://www.termedia.pl/The-role-of-exogenous-histamine-in-atopic-dermatitis-flare-ups,123,54688,1,1.html |
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| _version_ | 1832584854216114176 |
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| author | Zofia Kowalska Joanna Narbutt |
| author_facet | Zofia Kowalska Joanna Narbutt |
| author_sort | Zofia Kowalska |
| collection | DOAJ |
| description | Atopic dermatitis (AD) remains a significant challenge due to its chronic and relapsing nature, with various triggers exacerbating symptoms. While endogenous histamine’s role in AD is well documented, the impact of exogenous histamine remains controversial. This review explores the complex relationship between exogenous histamine and AD flare-ups, evaluating evidence for implementing low-histamine diets and diamine oxidase enzyme supplementation as a potential therapeutic intervention in a subgroup of AD patients. Histamine’s diverse physiological functions, its involvement in AD pathophysiology, and the potential implications of histamine intolerance and histamine overlay syndrome are examined. Studies suggest compromised metabolism and increased sensitivity to dietary histamine, highlighting the potential of low-histamine diets in managing symptoms. Despite limited research, preliminary findings underscore the need for further exploration of histamine-related reactions in AD and the therapeutic potential of low-histamine diets. Future research avenues include developing reliable screening tools and elucidating the relationships between gut microbiome dysbiosis and histamine metabolism in AD. |
| format | Article |
| id | doaj-art-3fee6dddf4cf47ae9f44b5d6612d9e2a |
| institution | Kabale University |
| issn | 2353-3854 2391-6052 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Alergologia Polska |
| spelling | doaj-art-3fee6dddf4cf47ae9f44b5d6612d9e2a2025-01-27T10:34:54ZengTermedia Publishing HouseAlergologia Polska2353-38542391-60522024-08-0111325125610.5114/pja.2024.14260454688The role of exogenous histamine in atopic dermatitis flare-upsZofia KowalskaJoanna NarbuttAtopic dermatitis (AD) remains a significant challenge due to its chronic and relapsing nature, with various triggers exacerbating symptoms. While endogenous histamine’s role in AD is well documented, the impact of exogenous histamine remains controversial. This review explores the complex relationship between exogenous histamine and AD flare-ups, evaluating evidence for implementing low-histamine diets and diamine oxidase enzyme supplementation as a potential therapeutic intervention in a subgroup of AD patients. Histamine’s diverse physiological functions, its involvement in AD pathophysiology, and the potential implications of histamine intolerance and histamine overlay syndrome are examined. Studies suggest compromised metabolism and increased sensitivity to dietary histamine, highlighting the potential of low-histamine diets in managing symptoms. Despite limited research, preliminary findings underscore the need for further exploration of histamine-related reactions in AD and the therapeutic potential of low-histamine diets. Future research avenues include developing reliable screening tools and elucidating the relationships between gut microbiome dysbiosis and histamine metabolism in AD.https://www.termedia.pl/The-role-of-exogenous-histamine-in-atopic-dermatitis-flare-ups,123,54688,1,1.htmlatopic dermatitis histamine intolerance low-histamine diet diamine oxidase |
| spellingShingle | Zofia Kowalska Joanna Narbutt The role of exogenous histamine in atopic dermatitis flare-ups Alergologia Polska atopic dermatitis histamine intolerance low-histamine diet diamine oxidase |
| title | The role of exogenous histamine in atopic dermatitis flare-ups |
| title_full | The role of exogenous histamine in atopic dermatitis flare-ups |
| title_fullStr | The role of exogenous histamine in atopic dermatitis flare-ups |
| title_full_unstemmed | The role of exogenous histamine in atopic dermatitis flare-ups |
| title_short | The role of exogenous histamine in atopic dermatitis flare-ups |
| title_sort | role of exogenous histamine in atopic dermatitis flare ups |
| topic | atopic dermatitis histamine intolerance low-histamine diet diamine oxidase |
| url | https://www.termedia.pl/The-role-of-exogenous-histamine-in-atopic-dermatitis-flare-ups,123,54688,1,1.html |
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