Therapeutic Effect of Shikimic Acid on Heat Stress-Induced Myocardial Damage: Assessment via Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Experiments

Therapeutic Effect of Shikimic Acid on Heat Stress-Induced Myocardial Damage: Assessment via Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Experiments

<b>Abstract:</b> Background: Rising global temperatures have been linked to an increased incidence of heat stress (HS)-induced myocardial damage. Methods: This study aimed to investigate the therapeutic potential of shikimic acid (SA) on HS-induced myocardial damage using network pharmac...

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Bibliographic Details
Main Authors: Yan Gu, Jingyi Zhang, Haohong Zheng, Yuyang Qin, Min Zheng, Yanchun Hu, Jialiang Xin
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceuticals
Subjects:
network pharmacology
heat stress
myocardial damage
shikimic acid
molecular docking
molecular dynamics simulation
Online Access:https://www.mdpi.com/1424-8247/17/11/1485
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