Multifaceted neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) in Alzheimer’s disease: an overview of pre-clinical studies focused on β-amyloid peptide
ABSTRACT: Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by cognitive decline and memory impairment. Many lines of evidence indicate that excessive β-amyloid peptide (Aβ) generation and aggregation play pivotal roles in the initiation of AD, leading to various bi...
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Tsinghua University Press
2022-05-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021001348 |
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| author | Kumju Youn Chi-Tang Ho Mira Jun |
| author_facet | Kumju Youn Chi-Tang Ho Mira Jun |
| author_sort | Kumju Youn |
| collection | DOAJ |
| description | ABSTRACT: Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by cognitive decline and memory impairment. Many lines of evidence indicate that excessive β-amyloid peptide (Aβ) generation and aggregation play pivotal roles in the initiation of AD, leading to various biochemical alteration including oxidative damage, mitochondrial dysfunction, neuroinflammation, signaling pathway and finally resulting in neuronal death. AD has a complex pathogenic mechanism, and a single-target approach for anti-AD strategy is thus full of challenges. To overcome these limitations, the present study focused to review on one of multiple target-compounds, (–)-epigallocatechin-3-gallate (EGCG) for the prevention and treatment of AD. EGCG is a main bioactive polyphenol in green tea and has been reported to exert potent neuroprotective properties in a wide array of both cellular and animal models in AD. This review demonstrated multiple neuroprotective efficacies of EGCG by focusing on the involvement of Aβ-evoked damage and its Aβ regulation. Furthermore, to understand its mechanism of action on the brain, the permeability of the blood-brain barrier was also discussed. |
| format | Article |
| id | doaj-art-3fd9ec33e25d4c46ad748f3b8dfcb29d |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-05-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-3fd9ec33e25d4c46ad748f3b8dfcb29d2025-02-02T23:24:54ZengTsinghua University PressFood Science and Human Wellness2213-45302022-05-01113483493Multifaceted neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) in Alzheimer’s disease: an overview of pre-clinical studies focused on β-amyloid peptideKumju Youn0Chi-Tang Ho1Mira Jun2Department of Food Science and Nutrition, Dong-A University, Busan 49315, KoreaDepartment of Food Science, Rutgers University, NJ 08901, USADepartment of Food Science and Nutrition, Dong-A University, Busan 49315, Korea; Department of Health Sciences, The graduate School of Dong-A University, Busan 49315, Korea; Corresponding author at: Department of Food Science and Nutrition, Dong-A University, Busan 49315, Korea.ABSTRACT: Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by cognitive decline and memory impairment. Many lines of evidence indicate that excessive β-amyloid peptide (Aβ) generation and aggregation play pivotal roles in the initiation of AD, leading to various biochemical alteration including oxidative damage, mitochondrial dysfunction, neuroinflammation, signaling pathway and finally resulting in neuronal death. AD has a complex pathogenic mechanism, and a single-target approach for anti-AD strategy is thus full of challenges. To overcome these limitations, the present study focused to review on one of multiple target-compounds, (–)-epigallocatechin-3-gallate (EGCG) for the prevention and treatment of AD. EGCG is a main bioactive polyphenol in green tea and has been reported to exert potent neuroprotective properties in a wide array of both cellular and animal models in AD. This review demonstrated multiple neuroprotective efficacies of EGCG by focusing on the involvement of Aβ-evoked damage and its Aβ regulation. Furthermore, to understand its mechanism of action on the brain, the permeability of the blood-brain barrier was also discussed.http://www.sciencedirect.com/science/article/pii/S2213453021001348Alzheimer’s diseaseβ-Amyloid peptideGreen teaEGCGNeuroinflammation |
| spellingShingle | Kumju Youn Chi-Tang Ho Mira Jun Multifaceted neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) in Alzheimer’s disease: an overview of pre-clinical studies focused on β-amyloid peptide Food Science and Human Wellness Alzheimer’s disease β-Amyloid peptide Green tea EGCG Neuroinflammation |
| title | Multifaceted neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) in Alzheimer’s disease: an overview of pre-clinical studies focused on β-amyloid peptide |
| title_full | Multifaceted neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) in Alzheimer’s disease: an overview of pre-clinical studies focused on β-amyloid peptide |
| title_fullStr | Multifaceted neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) in Alzheimer’s disease: an overview of pre-clinical studies focused on β-amyloid peptide |
| title_full_unstemmed | Multifaceted neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) in Alzheimer’s disease: an overview of pre-clinical studies focused on β-amyloid peptide |
| title_short | Multifaceted neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) in Alzheimer’s disease: an overview of pre-clinical studies focused on β-amyloid peptide |
| title_sort | multifaceted neuroprotective effects of epigallocatechin 3 gallate egcg in alzheimer s disease an overview of pre clinical studies focused on β amyloid peptide |
| topic | Alzheimer’s disease β-Amyloid peptide Green tea EGCG Neuroinflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021001348 |
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