Factors determining homocysteine levels in Russian patients with stable coronary heart disease
Aim. To identify the factors determining homocysteine (HMC) levels in Russian patients with stable coronary heart disease (CHD). Material and methods. The study included 506 patients (388 men; mean age 59,4±12,2 years) with stable CHD. Classical risk factors (RFs) of cardiovascular disease (CVD), re...
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«SILICEA-POLIGRAF» LLC
2010-08-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2105 |
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| author | O. O. Shakhmatova A. L. Komarov D. V. Rebrikov M. A. Turchaninova T. I. Kotkina A. V. Bolvacheva A. D. Deev A. B. Dobrovolsky E. V. Titaeva E. A. Panchenko |
| author_facet | O. O. Shakhmatova A. L. Komarov D. V. Rebrikov M. A. Turchaninova T. I. Kotkina A. V. Bolvacheva A. D. Deev A. B. Dobrovolsky E. V. Titaeva E. A. Panchenko |
| author_sort | O. O. Shakhmatova |
| collection | DOAJ |
| description | Aim. To identify the factors determining homocysteine (HMC) levels in Russian patients with stable coronary heart disease (CHD). Material and methods. The study included 506 patients (388 men; mean age 59,4±12,2 years) with stable CHD. Classical risk factors (RFs) of cardiovascular disease (CVD), renal function (creatinine clearance by Cockroft-Gault formula), and atherosclerotic pathology of other localizations were assessed. The levels of plasma HMC, folate, and cobalamin were measured. Genetic analysis was performed using the real-time polymerase chain reaction method. Results. In 432 patients (85,4 %), hyperhomocysteinemia was diagnosed. The mean HMC level was 14,3±4,6 mkmol/l. According to multifactor analysis results, HMC level was independently associated with folate level (beta coefficient -3,86, p<0,0001), cobalamin level (beta -5,73, p<0,0001), and MTRR 66AA genotype (beta 10,71, p<0,0005). In addition, HMC concentration was linked to the following combinations: MTRR 66G allele + folate level (beta 1,12, p<0,0001), MTRR 66AA allele + cobalamin level (beta 0,012, p<0,0001), TCN 776G allele + cobalamin level (beta -0,03, p<0,0001), TCN 776G allele + folate level (beta 0,58, p<0,0009), MTR 2756G allele + cobalamin level (beta 0,004, p<0,002), MTRR 66G allele + creatinine clearance <90 ml/min (beta 0,08, p<0,001), and TCN 776G allele + creatinine clearance <90 ml/min (beta 0,07, p<0,0007). Conclusion. In Russian patients with stable CHD, HMC level was associated with folate and cobalamin concentrations and MTRR 66AA genotype, as well as with MTR 2756G, MTRR 66G, and TCN 776G alleles combined with vitamin concentrations and renal function. |
| format | Article |
| id | doaj-art-3fd941d2f5c246d29eaf20407799db75 |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2010-08-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-3fd941d2f5c246d29eaf20407799db752025-08-20T03:21:40Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252010-08-019449581814Factors determining homocysteine levels in Russian patients with stable coronary heart diseaseO. O. Shakhmatova0A. L. Komarov1D. V. Rebrikov2M. A. Turchaninova3T. I. Kotkina4A. V. Bolvacheva5A. D. Deev6A. B. Dobrovolsky7E. V. Titaeva8E. A. Panchenko9Russian Cardiology Scientific and Clinical ComplexRussian Cardiology Scientific and Clinical ComplexDNA-Technology Company; N.I. Vavilov Institute of General Genetics; Russian Academy of SciencesDNA-Technology CompanyRussian Cardiology Scientific and Clinical ComplexRussian Cardiology Scientific and Clinical ComplexState Research Centre f or Preventive Medicine. MoscowRussian Cardiology Scientific and Clinical ComplexRussian Cardiology Scientific and Clinical ComplexRussian Cardiology Scientific and Clinical ComplexAim. To identify the factors determining homocysteine (HMC) levels in Russian patients with stable coronary heart disease (CHD). Material and methods. The study included 506 patients (388 men; mean age 59,4±12,2 years) with stable CHD. Classical risk factors (RFs) of cardiovascular disease (CVD), renal function (creatinine clearance by Cockroft-Gault formula), and atherosclerotic pathology of other localizations were assessed. The levels of plasma HMC, folate, and cobalamin were measured. Genetic analysis was performed using the real-time polymerase chain reaction method. Results. In 432 patients (85,4 %), hyperhomocysteinemia was diagnosed. The mean HMC level was 14,3±4,6 mkmol/l. According to multifactor analysis results, HMC level was independently associated with folate level (beta coefficient -3,86, p<0,0001), cobalamin level (beta -5,73, p<0,0001), and MTRR 66AA genotype (beta 10,71, p<0,0005). In addition, HMC concentration was linked to the following combinations: MTRR 66G allele + folate level (beta 1,12, p<0,0001), MTRR 66AA allele + cobalamin level (beta 0,012, p<0,0001), TCN 776G allele + cobalamin level (beta -0,03, p<0,0001), TCN 776G allele + folate level (beta 0,58, p<0,0009), MTR 2756G allele + cobalamin level (beta 0,004, p<0,002), MTRR 66G allele + creatinine clearance <90 ml/min (beta 0,08, p<0,001), and TCN 776G allele + creatinine clearance <90 ml/min (beta 0,07, p<0,0007). Conclusion. In Russian patients with stable CHD, HMC level was associated with folate and cobalamin concentrations and MTRR 66AA genotype, as well as with MTR 2756G, MTRR 66G, and TCN 776G alleles combined with vitamin concentrations and renal function.https://cardiovascular.elpub.ru/jour/article/view/2105homocysteineatherothrombosisfolatecobalamingenetic polymorphism |
| spellingShingle | O. O. Shakhmatova A. L. Komarov D. V. Rebrikov M. A. Turchaninova T. I. Kotkina A. V. Bolvacheva A. D. Deev A. B. Dobrovolsky E. V. Titaeva E. A. Panchenko Factors determining homocysteine levels in Russian patients with stable coronary heart disease Кардиоваскулярная терапия и профилактика homocysteine atherothrombosis folate cobalamin genetic polymorphism |
| title | Factors determining homocysteine levels in Russian patients with stable coronary heart disease |
| title_full | Factors determining homocysteine levels in Russian patients with stable coronary heart disease |
| title_fullStr | Factors determining homocysteine levels in Russian patients with stable coronary heart disease |
| title_full_unstemmed | Factors determining homocysteine levels in Russian patients with stable coronary heart disease |
| title_short | Factors determining homocysteine levels in Russian patients with stable coronary heart disease |
| title_sort | factors determining homocysteine levels in russian patients with stable coronary heart disease |
| topic | homocysteine atherothrombosis folate cobalamin genetic polymorphism |
| url | https://cardiovascular.elpub.ru/jour/article/view/2105 |
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