Mitochondria-based medicine
At the balance between human health and disease (from the very first moments to the end of life), the mitochondrion is central players because of its metabolic role in adenosine triphosphate synthesis, cell signaling, immune response, and other processes of clinical interest. On the other hand, impa...
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| Format: | Article |
| Language: | English |
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Permanyer
2025-01-01
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| Series: | Boletín Médico del Hospital Infantil de México |
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| Online Access: | https://www.bmhim.com/frame_eng.php?id=469 |
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| author | Salvador Vázquez-Vega José D. Martínez-Ezquerro Sergio Sánchez-García Edwin R. Marka-Castro Fernando Minauro-Sanmiguel |
| author_facet | Salvador Vázquez-Vega José D. Martínez-Ezquerro Sergio Sánchez-García Edwin R. Marka-Castro Fernando Minauro-Sanmiguel |
| author_sort | Salvador Vázquez-Vega |
| collection | DOAJ |
| description | At the balance between human health and disease (from the very first moments to the end of life), the mitochondrion is central players because of its metabolic role in adenosine triphosphate synthesis, cell signaling, immune response, and other processes of clinical interest. On the other hand, impairments at the optimal mitochondria function have important consequences in complex diseases, such as heart disease, diabetes, and cancer, among others. These mitochondrial impairments can occur at any age damaging multiple body systems, which have prompted the mitochondrial medicine development. Since mitochondrial diseases have great variability in their clinical manifestations, early studies were centered on mitochondriopathies, however nowadays, this focus has broadened to understand and encompass the mitochondrial role of in diseases development of both pediatric and adult age. The mitochondria potential to improve diagnostic, prognostic, and treatment response strategies has been revealed by experimental approaches using proteomics, genomics, and metabolomics to identify clinical biomarkers showing disease development. Thus, the perspective of mitochondria-based medicine recognizes the importance of generating scientific evidence related to mitochondria and their role in pathological conditions from a comprehensive approach.
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| format | Article |
| id | doaj-art-3fd253cf77924ee0bc24f632dcce9701 |
| institution | DOAJ |
| issn | 0539-6115 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Boletín Médico del Hospital Infantil de México |
| spelling | doaj-art-3fd253cf77924ee0bc24f632dcce97012025-08-20T02:57:55ZengPermanyerBoletín Médico del Hospital Infantil de México0539-61152025-01-0182110.24875/BMHIM.24000058Mitochondria-based medicineSalvador Vázquez-Vega0José D. Martínez-Ezquerro1Sergio Sánchez-García2Edwin R. Marka-Castro3Fernando Minauro-Sanmiguel4Unit of Epidemiological and Health Services Research, Instituto Mexicano del Seguro Social (IMSS), Centro Médico Nacional Siglo XXI, Mexico City, MexicoUnit of Epidemiological and Health Services Research, Aging Area, IMSS, Centro Médico Nacional Siglo XXI; Center for Complexity Sciences (C3), Universidad Nacional Autónoma de México, Mexico City, MexicoUnit of Epidemiological and Health Services Research, Aging Area, IMSS, Centro Médico Nacional Siglo XXI, Mexico City, MexicoCentro Médico Nacional Siglo XXI Hospital de Especialidades “Bernardo Sepúlveda Gutiérrez”, IMSS, Mexico City, MexicoUnit of Medical Research in Human Genetics, IMSS, Centro Médico Nacional Siglo XXI, Mexico City, MexicoAt the balance between human health and disease (from the very first moments to the end of life), the mitochondrion is central players because of its metabolic role in adenosine triphosphate synthesis, cell signaling, immune response, and other processes of clinical interest. On the other hand, impairments at the optimal mitochondria function have important consequences in complex diseases, such as heart disease, diabetes, and cancer, among others. These mitochondrial impairments can occur at any age damaging multiple body systems, which have prompted the mitochondrial medicine development. Since mitochondrial diseases have great variability in their clinical manifestations, early studies were centered on mitochondriopathies, however nowadays, this focus has broadened to understand and encompass the mitochondrial role of in diseases development of both pediatric and adult age. The mitochondria potential to improve diagnostic, prognostic, and treatment response strategies has been revealed by experimental approaches using proteomics, genomics, and metabolomics to identify clinical biomarkers showing disease development. Thus, the perspective of mitochondria-based medicine recognizes the importance of generating scientific evidence related to mitochondria and their role in pathological conditions from a comprehensive approach. https://www.bmhim.com/frame_eng.php?id=469Mitochondria. Mitochondrial diseases. Chronic non-communicable diseases. Metabolic diseases. |
| spellingShingle | Salvador Vázquez-Vega José D. Martínez-Ezquerro Sergio Sánchez-García Edwin R. Marka-Castro Fernando Minauro-Sanmiguel Mitochondria-based medicine Boletín Médico del Hospital Infantil de México Mitochondria. Mitochondrial diseases. Chronic non-communicable diseases. Metabolic diseases. |
| title | Mitochondria-based medicine |
| title_full | Mitochondria-based medicine |
| title_fullStr | Mitochondria-based medicine |
| title_full_unstemmed | Mitochondria-based medicine |
| title_short | Mitochondria-based medicine |
| title_sort | mitochondria based medicine |
| topic | Mitochondria. Mitochondrial diseases. Chronic non-communicable diseases. Metabolic diseases. |
| url | https://www.bmhim.com/frame_eng.php?id=469 |
| work_keys_str_mv | AT salvadorvazquezvega mitochondriabasedmedicine AT josedmartinezezquerro mitochondriabasedmedicine AT sergiosanchezgarcia mitochondriabasedmedicine AT edwinrmarkacastro mitochondriabasedmedicine AT fernandominaurosanmiguel mitochondriabasedmedicine |