Identification of three distinct cell populations for urate excretion in human kidneys

Identification of three distinct cell populations for urate excretion in human kidneys

Abstract In humans, uric acid is an end-product of purine metabolism. Urate excretion from the human kidney is tightly regulated by reabsorption and secretion. At least eleven genes have been identified as human renal urate transporters. However, it remains unclear whether all renal tubular cells ex...

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Bibliographic Details
Main Authors: Yoshihiko M. Sakaguchi, Pattama Wiriyasermkul, Masaya Matsubayashi, Masaki Miyasaka, Nau Sakaguchi, Yoshiki Sahara, Minoru Takasato, Kaoru Kinugawa, Kazuma Sugie, Masahiro Eriguchi, Kazuhiko Tsuruya, Hiroki Kuniyasu, Shushi Nagamori, Eiichiro Mori
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Journal of Physiological Sciences
Subjects:
Transporter
Single nucleus RNA-sequencing
Uric acid
Human kidney
Gout
Solute carriers
Online Access:https://doi.org/10.1186/s12576-023-00894-0
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