Management of antithrombin III deficiency in pregnancy: a representative case and a literature review
The work is aimed at discussing pregnancy management for the most thrombogenic genetic thrombophilia - antithrombin III (AT-III) deficiency. A detailed analysis of the literature and clinical case of pregnancy management in a patient with AT-III deficiency, pulmonary embolism and habitual history of...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IRBIS LLC
2021-09-01
|
| Series: | Акушерство, гинекология и репродукция |
| Subjects: | |
| Online Access: | https://www.gynecology.su/jour/article/view/1072 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850048581085429760 |
|---|---|
| author | S. V. Akinshina P. K. Genina V. O. Bitsadze J. Kh. Khizroeva V. I. Tsibizova A. D. Makatsariya |
| author_facet | S. V. Akinshina P. K. Genina V. O. Bitsadze J. Kh. Khizroeva V. I. Tsibizova A. D. Makatsariya |
| author_sort | S. V. Akinshina |
| collection | DOAJ |
| description | The work is aimed at discussing pregnancy management for the most thrombogenic genetic thrombophilia - antithrombin III (AT-III) deficiency. A detailed analysis of the literature and clinical case of pregnancy management in a patient with AT-III deficiency, pulmonary embolism and habitual history of miscarriage has been performed and presented. Patients with AT-III deficiency are at high risk for developing thrombotic and obstetric complications even despite using therapeutic doses of anticoagulants. Indications for use and modes of administration of AT-III concentrate have not been currently defined clearly. Monitoring therapy with low molecular weight heparin is largely complicated because a test for determining anti-Xa activity is AT-III-dependent. In addition to standard methods for controlling antithrombotic therapy, we used tests characterizing the dynamic blood clot parameters: thromboelastography and thrombin generation test. The peak risk resulting in both thrombotic and hemorrhagic complications in such patients occurs during period of labor and the postpartum period, when a change in the regimen of anticoagulant therapy is required with its temporary withdrawal and additional administration of AT-III concentrate. |
| format | Article |
| id | doaj-art-3fcfd617d6f04220847086d34c5e9fe5 |
| institution | DOAJ |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2021-09-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-3fcfd617d6f04220847086d34c5e9fe52025-08-20T02:53:55ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942021-09-0115444145010.17749/2313-7347/ob.gyn.rep.2021.230667Management of antithrombin III deficiency in pregnancy: a representative case and a literature reviewS. V. Akinshina0P. K. Genina1V. O. Bitsadze2J. Kh. Khizroeva3V. I. Tsibizova4A. D. Makatsariya5«Medical Centre for Women» LLCSechenov UniversitySechenov UniversitySechenov UniversityAlmazov National Medical Research Centre, Health Ministry of Russian FederationSechenov UniversityThe work is aimed at discussing pregnancy management for the most thrombogenic genetic thrombophilia - antithrombin III (AT-III) deficiency. A detailed analysis of the literature and clinical case of pregnancy management in a patient with AT-III deficiency, pulmonary embolism and habitual history of miscarriage has been performed and presented. Patients with AT-III deficiency are at high risk for developing thrombotic and obstetric complications even despite using therapeutic doses of anticoagulants. Indications for use and modes of administration of AT-III concentrate have not been currently defined clearly. Monitoring therapy with low molecular weight heparin is largely complicated because a test for determining anti-Xa activity is AT-III-dependent. In addition to standard methods for controlling antithrombotic therapy, we used tests characterizing the dynamic blood clot parameters: thromboelastography and thrombin generation test. The peak risk resulting in both thrombotic and hemorrhagic complications in such patients occurs during period of labor and the postpartum period, when a change in the regimen of anticoagulant therapy is required with its temporary withdrawal and additional administration of AT-III concentrate.https://www.gynecology.su/jour/article/view/1072antithrombin iii deficiencypregnancylow molecular weight heparinantithrombin iii concentraterivaroxaban |
| spellingShingle | S. V. Akinshina P. K. Genina V. O. Bitsadze J. Kh. Khizroeva V. I. Tsibizova A. D. Makatsariya Management of antithrombin III deficiency in pregnancy: a representative case and a literature review Акушерство, гинекология и репродукция antithrombin iii deficiency pregnancy low molecular weight heparin antithrombin iii concentrate rivaroxaban |
| title | Management of antithrombin III deficiency in pregnancy: a representative case and a literature review |
| title_full | Management of antithrombin III deficiency in pregnancy: a representative case and a literature review |
| title_fullStr | Management of antithrombin III deficiency in pregnancy: a representative case and a literature review |
| title_full_unstemmed | Management of antithrombin III deficiency in pregnancy: a representative case and a literature review |
| title_short | Management of antithrombin III deficiency in pregnancy: a representative case and a literature review |
| title_sort | management of antithrombin iii deficiency in pregnancy a representative case and a literature review |
| topic | antithrombin iii deficiency pregnancy low molecular weight heparin antithrombin iii concentrate rivaroxaban |
| url | https://www.gynecology.su/jour/article/view/1072 |
| work_keys_str_mv | AT svakinshina managementofantithrombiniiideficiencyinpregnancyarepresentativecaseandaliteraturereview AT pkgenina managementofantithrombiniiideficiencyinpregnancyarepresentativecaseandaliteraturereview AT vobitsadze managementofantithrombiniiideficiencyinpregnancyarepresentativecaseandaliteraturereview AT jkhkhizroeva managementofantithrombiniiideficiencyinpregnancyarepresentativecaseandaliteraturereview AT vitsibizova managementofantithrombiniiideficiencyinpregnancyarepresentativecaseandaliteraturereview AT admakatsariya managementofantithrombiniiideficiencyinpregnancyarepresentativecaseandaliteraturereview |