Metabolic musculoskeletal disorders in patients with inflammatory bowel disease
Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is a chronic inflammatory disorder that affects not only the gastrointestinal tract but also extraintestinal organs, leading to various extraintestinal manifestations and complications. Among these, musculoskele...
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The Korean Association of Internal Medicine
2025-03-01
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| Series: | The Korean Journal of Internal Medicine |
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| Online Access: | http://kjim.org/upload/kjim-2024-359.pdf |
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| author | Young Joo Yang Seong Ran Jeon |
| author_facet | Young Joo Yang Seong Ran Jeon |
| author_sort | Young Joo Yang |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is a chronic inflammatory disorder that affects not only the gastrointestinal tract but also extraintestinal organs, leading to various extraintestinal manifestations and complications. Among these, musculoskeletal disorders such as osteoporosis, sarcopenia, and axial and peripheral spondyloarthritis are the most commonly observed. These conditions arise from complex mechanisms, including chronic inflammation, malnutrition, gut dysbiosis, and glucocorticoid use, all of which contribute to reduced bone density, muscle loss, and joint inflammation. Osteoporosis and sarcopenia may co-occur as osteosarcopenia, a condition that heightens the risk of fractures, impairs physical performance, and diminishes quality of life, particularly in elderly patients with IBD. Holistic management strategies, including lifestyle modifications, calcium, and vitamin D supplementation, resistance training, and pharmacological interventions, are essential for mitigating the impact of these conditions. Spondyloarthritis, which affects both axial and peripheral joints, further complicates disease management and significantly compromises joint health. Timely diagnosis and appropriate medical interventions, such as administration of nonsteroidal anti-inflammatory drugs and biologics, are critical for preventing chronic joint damage and disability. Moreover, a multidisciplinary approach that addresses both metabolic and inflammatory aspects is essential for optimizing physical function and improving treatment outcomes in patients who have IBD with musculoskeletal involvement. |
| format | Article |
| id | doaj-art-3fcad9f4e37340d2bf64b4ac3819a71d |
| institution | DOAJ |
| issn | 1226-3303 2005-6648 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj-art-3fcad9f4e37340d2bf64b4ac3819a71d2025-08-20T03:07:20ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482025-03-0140218119510.3904/kjim.2024.359171002Metabolic musculoskeletal disorders in patients with inflammatory bowel diseaseYoung Joo Yang0Seong Ran Jeon1 Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea Digestive Disease Center, Institute for Digestive Research, Soonchunhyang University College of Medicine, Seoul, KoreaInflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is a chronic inflammatory disorder that affects not only the gastrointestinal tract but also extraintestinal organs, leading to various extraintestinal manifestations and complications. Among these, musculoskeletal disorders such as osteoporosis, sarcopenia, and axial and peripheral spondyloarthritis are the most commonly observed. These conditions arise from complex mechanisms, including chronic inflammation, malnutrition, gut dysbiosis, and glucocorticoid use, all of which contribute to reduced bone density, muscle loss, and joint inflammation. Osteoporosis and sarcopenia may co-occur as osteosarcopenia, a condition that heightens the risk of fractures, impairs physical performance, and diminishes quality of life, particularly in elderly patients with IBD. Holistic management strategies, including lifestyle modifications, calcium, and vitamin D supplementation, resistance training, and pharmacological interventions, are essential for mitigating the impact of these conditions. Spondyloarthritis, which affects both axial and peripheral joints, further complicates disease management and significantly compromises joint health. Timely diagnosis and appropriate medical interventions, such as administration of nonsteroidal anti-inflammatory drugs and biologics, are critical for preventing chronic joint damage and disability. Moreover, a multidisciplinary approach that addresses both metabolic and inflammatory aspects is essential for optimizing physical function and improving treatment outcomes in patients who have IBD with musculoskeletal involvement.http://kjim.org/upload/kjim-2024-359.pdfinflammatory bowel diseaseosteoporosissarcopenia, spondyloarthritis |
| spellingShingle | Young Joo Yang Seong Ran Jeon Metabolic musculoskeletal disorders in patients with inflammatory bowel disease The Korean Journal of Internal Medicine inflammatory bowel disease osteoporosis sarcopenia, spondyloarthritis |
| title | Metabolic musculoskeletal disorders in patients with inflammatory bowel disease |
| title_full | Metabolic musculoskeletal disorders in patients with inflammatory bowel disease |
| title_fullStr | Metabolic musculoskeletal disorders in patients with inflammatory bowel disease |
| title_full_unstemmed | Metabolic musculoskeletal disorders in patients with inflammatory bowel disease |
| title_short | Metabolic musculoskeletal disorders in patients with inflammatory bowel disease |
| title_sort | metabolic musculoskeletal disorders in patients with inflammatory bowel disease |
| topic | inflammatory bowel disease osteoporosis sarcopenia, spondyloarthritis |
| url | http://kjim.org/upload/kjim-2024-359.pdf |
| work_keys_str_mv | AT youngjooyang metabolicmusculoskeletaldisordersinpatientswithinflammatoryboweldisease AT seongranjeon metabolicmusculoskeletaldisordersinpatientswithinflammatoryboweldisease |