The AusAB non-ribosomal peptide synthetase of Staphylococcus aureus preferentially generates phevalin in host-mimicking media

The AusAB non-ribosomal peptide synthetase of Staphylococcus aureus preferentially generates phevalin in host-mimicking media

ABSTRACT Non-ribosomal peptide synthetases (NRPSs) are modular multidomain enzymes responsible for the biosynthesis of various secondary metabolites in an mRNA template-independent manner. They are predominantly present in bacteria and fungi, where they synthesize a variety of products, including an...

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Bibliographic Details
Main Authors: Adriana Moldovan, Markus Krischke, Claudia Huber, Clara Hans, Martin J. Müller, Wolfgang Eisenreich, Thomas Rudel, Martin J. Fraunholz
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mBio
Subjects:
Staphylococcus aureus
non-ribosomal peptide synthetases
aureusimines
phevalin
tyrvalin
Online Access:https://journals.asm.org/doi/10.1128/mbio.00845-24
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