miR-3154 promotes glioblastoma proliferation and metastasis via targeting TP53INP1
Abstract Glioblastomas (GBM) are most common types of primary brain tumors and miRNAs play an important role in pathogenesis of glioblastomas. Here, we reported a new miRNA, miR-3154, which regulates glioblastoma proliferation and metastasis. miR-3154 was elevated in glioblastoma tissue and cell lin...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Cell Division |
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| Online Access: | https://doi.org/10.1186/s13008-024-00134-w |
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| author | Xiangdan Lin Qiong Wu Wei Lei Dongyang Wu Jianchun Sheng Guobiao Liang Guojun Hou Di Fan |
| author_facet | Xiangdan Lin Qiong Wu Wei Lei Dongyang Wu Jianchun Sheng Guobiao Liang Guojun Hou Di Fan |
| author_sort | Xiangdan Lin |
| collection | DOAJ |
| description | Abstract Glioblastomas (GBM) are most common types of primary brain tumors and miRNAs play an important role in pathogenesis of glioblastomas. Here, we reported a new miRNA, miR-3154, which regulates glioblastoma proliferation and metastasis. miR-3154 was elevated in glioblastoma tissue and cell lines, and its elevation was associated with grade of glioblastomas. Knockdown of miR-3154 in cell lines weakened ability of proliferation and colony formation, and caused cell cycle arrested and higher percentage of apoptosis. Knockdown of miR-3154 also impaired ability of migration and invasion in glioblastoma cells. In mechanism, miR-3154 bound directly to Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1), down-regulating TP53INP1 expression at both mRNA and protein level. Silence of TP53INP1 reversed the effect of miR-3154 knockdown on proliferation and metastasis of glioblastoma cells. These findings show that miR-3154 promotes glioblastoma proliferation and metastasis via targeting TP53INP1. |
| format | Article |
| id | doaj-art-3fc48dedb61e475780da942ed69992d7 |
| institution | OA Journals |
| issn | 1747-1028 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Division |
| spelling | doaj-art-3fc48dedb61e475780da942ed69992d72025-08-20T02:18:35ZengBMCCell Division1747-10282024-11-0119111010.1186/s13008-024-00134-wmiR-3154 promotes glioblastoma proliferation and metastasis via targeting TP53INP1Xiangdan Lin0Qiong Wu1Wei Lei2Dongyang Wu3Jianchun Sheng4Guobiao Liang5Guojun Hou6Di Fan7Department of Neurosurgery, General Hospital of Northern Theater CommandDepartment of Thoracic Surgery, General Hospital of Northern Theater CommandDepartment of Neurosurgery, General Hospital of Northern Theater CommandDepartment of Neurosurgery, General Hospital of Northern Theater CommandDepartment of Neurosurgery, General Hospital of Northern Theater CommandDepartment of Neurosurgery, General Hospital of Northern Theater CommandDepartment of General Surgery, Third Affiliated Hospital of Second Military Medical UniversityDepartment of Neurosurgery, General Hospital of Northern Theater CommandAbstract Glioblastomas (GBM) are most common types of primary brain tumors and miRNAs play an important role in pathogenesis of glioblastomas. Here, we reported a new miRNA, miR-3154, which regulates glioblastoma proliferation and metastasis. miR-3154 was elevated in glioblastoma tissue and cell lines, and its elevation was associated with grade of glioblastomas. Knockdown of miR-3154 in cell lines weakened ability of proliferation and colony formation, and caused cell cycle arrested and higher percentage of apoptosis. Knockdown of miR-3154 also impaired ability of migration and invasion in glioblastoma cells. In mechanism, miR-3154 bound directly to Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1), down-regulating TP53INP1 expression at both mRNA and protein level. Silence of TP53INP1 reversed the effect of miR-3154 knockdown on proliferation and metastasis of glioblastoma cells. These findings show that miR-3154 promotes glioblastoma proliferation and metastasis via targeting TP53INP1.https://doi.org/10.1186/s13008-024-00134-wmiR-3154GlioblastomaTP53INP1ProliferationMetastasis |
| spellingShingle | Xiangdan Lin Qiong Wu Wei Lei Dongyang Wu Jianchun Sheng Guobiao Liang Guojun Hou Di Fan miR-3154 promotes glioblastoma proliferation and metastasis via targeting TP53INP1 Cell Division miR-3154 Glioblastoma TP53INP1 Proliferation Metastasis |
| title | miR-3154 promotes glioblastoma proliferation and metastasis via targeting TP53INP1 |
| title_full | miR-3154 promotes glioblastoma proliferation and metastasis via targeting TP53INP1 |
| title_fullStr | miR-3154 promotes glioblastoma proliferation and metastasis via targeting TP53INP1 |
| title_full_unstemmed | miR-3154 promotes glioblastoma proliferation and metastasis via targeting TP53INP1 |
| title_short | miR-3154 promotes glioblastoma proliferation and metastasis via targeting TP53INP1 |
| title_sort | mir 3154 promotes glioblastoma proliferation and metastasis via targeting tp53inp1 |
| topic | miR-3154 Glioblastoma TP53INP1 Proliferation Metastasis |
| url | https://doi.org/10.1186/s13008-024-00134-w |
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