The Lupus Check 5 Tool: A Practical Approach to Initiating Treatment Reviews in Systemic Lupus Erythematosus
Abstract Although the treatment landscape for systemic lupus erythematosus (SLE) has evolved in recent years, there is still a significant unmet need and many patients do not achieve key treatment goals, such as remission and low disease activity. Failure to reach these goals increases the risk of f...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2025-05-01
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| Series: | Rheumatology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40744-025-00770-w |
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| author | Anca Askanase Antonis Fanouriakis Lyra Agustin Maria Dall’Era Marta Mosca Yoshiya Tanaka |
| author_facet | Anca Askanase Antonis Fanouriakis Lyra Agustin Maria Dall’Era Marta Mosca Yoshiya Tanaka |
| author_sort | Anca Askanase |
| collection | DOAJ |
| description | Abstract Although the treatment landscape for systemic lupus erythematosus (SLE) has evolved in recent years, there is still a significant unmet need and many patients do not achieve key treatment goals, such as remission and low disease activity. Failure to reach these goals increases the risk of flare, organ damage accrual, and mortality in patients with SLE, and can have a significant impact on patient quality of life (QOL). While the importance of monitoring patients with SLE is highlighted across treatment recommendations, there is no clinical guidance on how to identify patients at risk of disease exacerbation and when to effectively initiate treatment reviews to improve their clinical outcomes. To address this, a panel of lupus experts have developed a clinical decision aid named the Lupus Check 5 Tool, which aims to identify patients in need of a treatment review through a simple five-question checklist. These questions cover a range of topics, including persistent glucocorticoid use, ongoing disease activity despite therapy, monitoring changes in laboratory values, flare frequency and severity, and the incorporation of the patient perspective and shared decision-making into clinical practice. Herein, we provide a detailed overview of the tool questions and the clinical evidence supporting their use to identify patients at risk of disease worsening. Use of the Lupus Check 5 Tool during each patient visit could facilitate timely alteration of therapy to help reduce disease activity, improve QOL, and work toward the long-term goals of remission and low disease activity. |
| format | Article |
| id | doaj-art-3fc2e3ba6c3c49b7bb9a5df7fa5fb0b3 |
| institution | DOAJ |
| issn | 2198-6576 2198-6584 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Rheumatology and Therapy |
| spelling | doaj-art-3fc2e3ba6c3c49b7bb9a5df7fa5fb0b32025-08-20T03:06:05ZengAdis, Springer HealthcareRheumatology and Therapy2198-65762198-65842025-05-0112473174010.1007/s40744-025-00770-wThe Lupus Check 5 Tool: A Practical Approach to Initiating Treatment Reviews in Systemic Lupus ErythematosusAnca Askanase0Antonis Fanouriakis1Lyra Agustin2Maria Dall’Era3Marta Mosca4Yoshiya Tanaka5Department of Medicine, Columbia University Irving Medical CenterRheumatology and Clinical Immunology Unit, Attikon University Hospital, National and Kapodistrian University of Athens School of MedicineBiopharmaceuticals Medical, AstraZenecaDivision of Rheumatology, University of California San Francisco School of MedicineRheumatology Unit, University of PisaFirst Department of Internal Medicine, School of Medicine, University of Occupational and Environmental HealthAbstract Although the treatment landscape for systemic lupus erythematosus (SLE) has evolved in recent years, there is still a significant unmet need and many patients do not achieve key treatment goals, such as remission and low disease activity. Failure to reach these goals increases the risk of flare, organ damage accrual, and mortality in patients with SLE, and can have a significant impact on patient quality of life (QOL). While the importance of monitoring patients with SLE is highlighted across treatment recommendations, there is no clinical guidance on how to identify patients at risk of disease exacerbation and when to effectively initiate treatment reviews to improve their clinical outcomes. To address this, a panel of lupus experts have developed a clinical decision aid named the Lupus Check 5 Tool, which aims to identify patients in need of a treatment review through a simple five-question checklist. These questions cover a range of topics, including persistent glucocorticoid use, ongoing disease activity despite therapy, monitoring changes in laboratory values, flare frequency and severity, and the incorporation of the patient perspective and shared decision-making into clinical practice. Herein, we provide a detailed overview of the tool questions and the clinical evidence supporting their use to identify patients at risk of disease worsening. Use of the Lupus Check 5 Tool during each patient visit could facilitate timely alteration of therapy to help reduce disease activity, improve QOL, and work toward the long-term goals of remission and low disease activity.https://doi.org/10.1007/s40744-025-00770-wClinical managementSystemic lupus erythematosusTreatment review |
| spellingShingle | Anca Askanase Antonis Fanouriakis Lyra Agustin Maria Dall’Era Marta Mosca Yoshiya Tanaka The Lupus Check 5 Tool: A Practical Approach to Initiating Treatment Reviews in Systemic Lupus Erythematosus Rheumatology and Therapy Clinical management Systemic lupus erythematosus Treatment review |
| title | The Lupus Check 5 Tool: A Practical Approach to Initiating Treatment Reviews in Systemic Lupus Erythematosus |
| title_full | The Lupus Check 5 Tool: A Practical Approach to Initiating Treatment Reviews in Systemic Lupus Erythematosus |
| title_fullStr | The Lupus Check 5 Tool: A Practical Approach to Initiating Treatment Reviews in Systemic Lupus Erythematosus |
| title_full_unstemmed | The Lupus Check 5 Tool: A Practical Approach to Initiating Treatment Reviews in Systemic Lupus Erythematosus |
| title_short | The Lupus Check 5 Tool: A Practical Approach to Initiating Treatment Reviews in Systemic Lupus Erythematosus |
| title_sort | lupus check 5 tool a practical approach to initiating treatment reviews in systemic lupus erythematosus |
| topic | Clinical management Systemic lupus erythematosus Treatment review |
| url | https://doi.org/10.1007/s40744-025-00770-w |
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