Boehmeria nivea Attenuates the Development of Dextran Sulfate Sodium-Induced Experimental Colitis
We examined the therapeutic effect of an ethanol extract derived from Boehmeria nivea (Linn.) Gaudich in a mouse model of experimental colitis. Treatment with 70% ethanol extract derived from B. nivea (EBN) at a dose of 100, 200, or 500 mg/(kg·d) improved colon shortening, body weight, the disease a...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/231942 |
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| author | Eun Ju Shin Mi Jeong Sung Hye Jeong Yang Myung Sunny Kim Jin-Taek Hwang |
| author_facet | Eun Ju Shin Mi Jeong Sung Hye Jeong Yang Myung Sunny Kim Jin-Taek Hwang |
| author_sort | Eun Ju Shin |
| collection | DOAJ |
| description | We examined the therapeutic effect of an ethanol extract derived from Boehmeria nivea (Linn.) Gaudich in a mouse model of experimental colitis. Treatment with 70% ethanol extract derived from B. nivea (EBN) at a dose of 100, 200, or 500 mg/(kg·d) improved colon shortening, body weight, the disease activity index (DAI), and histopathological score of DSS-induced colitis mice. DSS significantly increased the levels of cyclooxygenase-(COX-) 2 in colon tissue relative to that of the untreated control group. EBN administered at 100, 200, or 500 mg/(kg·d) reduced COX-2 levels in the DSS-treated mice. In addition, EBN decreased the DSS-induced secretion of the inflammatory cytokine interleukin-6 (IL-6) and chemokine monocyte chemotactic protein-1 (MCP-1). Taken together, these data suggest that B. nivea extract is effective in preventing colitis. |
| format | Article |
| id | doaj-art-3fbe5f9b02ed4a598d4400ac780e33d1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3fbe5f9b02ed4a598d4400ac780e33d12025-02-03T07:25:25ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/231942231942Boehmeria nivea Attenuates the Development of Dextran Sulfate Sodium-Induced Experimental ColitisEun Ju Shin0Mi Jeong Sung1Hye Jeong Yang2Myung Sunny Kim3Jin-Taek Hwang4Department of Food Biotechnology, University of Science & Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 305-333, Republic of KoreaKorea Food Research Institute, 1201 Anyangpangyoro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-746, Republic of KoreaKorea Food Research Institute, 1201 Anyangpangyoro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-746, Republic of KoreaKorea Food Research Institute, 1201 Anyangpangyoro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-746, Republic of KoreaDepartment of Food Biotechnology, University of Science & Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 305-333, Republic of KoreaWe examined the therapeutic effect of an ethanol extract derived from Boehmeria nivea (Linn.) Gaudich in a mouse model of experimental colitis. Treatment with 70% ethanol extract derived from B. nivea (EBN) at a dose of 100, 200, or 500 mg/(kg·d) improved colon shortening, body weight, the disease activity index (DAI), and histopathological score of DSS-induced colitis mice. DSS significantly increased the levels of cyclooxygenase-(COX-) 2 in colon tissue relative to that of the untreated control group. EBN administered at 100, 200, or 500 mg/(kg·d) reduced COX-2 levels in the DSS-treated mice. In addition, EBN decreased the DSS-induced secretion of the inflammatory cytokine interleukin-6 (IL-6) and chemokine monocyte chemotactic protein-1 (MCP-1). Taken together, these data suggest that B. nivea extract is effective in preventing colitis.http://dx.doi.org/10.1155/2014/231942 |
| spellingShingle | Eun Ju Shin Mi Jeong Sung Hye Jeong Yang Myung Sunny Kim Jin-Taek Hwang Boehmeria nivea Attenuates the Development of Dextran Sulfate Sodium-Induced Experimental Colitis Mediators of Inflammation |
| title | Boehmeria nivea Attenuates the Development of Dextran Sulfate Sodium-Induced Experimental Colitis |
| title_full | Boehmeria nivea Attenuates the Development of Dextran Sulfate Sodium-Induced Experimental Colitis |
| title_fullStr | Boehmeria nivea Attenuates the Development of Dextran Sulfate Sodium-Induced Experimental Colitis |
| title_full_unstemmed | Boehmeria nivea Attenuates the Development of Dextran Sulfate Sodium-Induced Experimental Colitis |
| title_short | Boehmeria nivea Attenuates the Development of Dextran Sulfate Sodium-Induced Experimental Colitis |
| title_sort | boehmeria nivea attenuates the development of dextran sulfate sodium induced experimental colitis |
| url | http://dx.doi.org/10.1155/2014/231942 |
| work_keys_str_mv | AT eunjushin boehmerianiveaattenuatesthedevelopmentofdextransulfatesodiuminducedexperimentalcolitis AT mijeongsung boehmerianiveaattenuatesthedevelopmentofdextransulfatesodiuminducedexperimentalcolitis AT hyejeongyang boehmerianiveaattenuatesthedevelopmentofdextransulfatesodiuminducedexperimentalcolitis AT myungsunnykim boehmerianiveaattenuatesthedevelopmentofdextransulfatesodiuminducedexperimentalcolitis AT jintaekhwang boehmerianiveaattenuatesthedevelopmentofdextransulfatesodiuminducedexperimentalcolitis |