The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of pati...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/4320195 |
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| author | Shang-Chen Yang Sindy Hu Sheng-Zheng Zhang Jin-wen Huang Jing Zhang Chao Ji Bo Cheng |
| author_facet | Shang-Chen Yang Sindy Hu Sheng-Zheng Zhang Jin-wen Huang Jing Zhang Chao Ji Bo Cheng |
| author_sort | Shang-Chen Yang |
| collection | DOAJ |
| description | Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN from the China National Knowledge Infrastructure (CNKI) and Wanfang database from 2006 to 2016 and patients with SJS/TEN who were admitted to the First Affiliated Hospital of Fujian Medical University during the same period. There were 166 patients enrolled, including 70 SJS, 2 SJS/TEN overlap, and 94 TEN. The most common offending drugs were antibiotics (29.5%) and anticonvulsants (24.1%). Carbamazepine, allopurinol, and penicillins were the most common single offending drugs (17.5%, 9.6%, and 7.2%). Chinese patent medicines accounted for 5.4%. There were 76 (45.8%) patients receiving systemic steroid and intravenous immunoglobulin (IVIG) in combination therapy, especially for TEN (80.3%), and others were treated with systemic steroids alone. Mortality rate of combination treatment comparing with steroid alone in TEN patients had no statistical significance. In conclusion, carbamazepine and allopurinol were the leading causative drugs for SJS/TEN in China. Combination of IVIG and steroids is a common treatment for TEN, but its efficacy in improving mortality needs further investigation. |
| format | Article |
| id | doaj-art-3fbc7946404c4fe0be6a5a3b69cdb0d9 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-3fbc7946404c4fe0be6a5a3b69cdb0d92025-02-03T01:32:07ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/43201954320195The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in ChinaShang-Chen Yang0Sindy Hu1Sheng-Zheng Zhang2Jin-wen Huang3Jing Zhang4Chao Ji5Bo Cheng6Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, Fujian, ChinaDepartment of Dermatology, Xiamen Chang Gung Hospital, Xiamen, Fujian, ChinaDepartment of Dermatology, Xiamen Chang Gung Hospital, Xiamen, Fujian, ChinaDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, ChinaStevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN from the China National Knowledge Infrastructure (CNKI) and Wanfang database from 2006 to 2016 and patients with SJS/TEN who were admitted to the First Affiliated Hospital of Fujian Medical University during the same period. There were 166 patients enrolled, including 70 SJS, 2 SJS/TEN overlap, and 94 TEN. The most common offending drugs were antibiotics (29.5%) and anticonvulsants (24.1%). Carbamazepine, allopurinol, and penicillins were the most common single offending drugs (17.5%, 9.6%, and 7.2%). Chinese patent medicines accounted for 5.4%. There were 76 (45.8%) patients receiving systemic steroid and intravenous immunoglobulin (IVIG) in combination therapy, especially for TEN (80.3%), and others were treated with systemic steroids alone. Mortality rate of combination treatment comparing with steroid alone in TEN patients had no statistical significance. In conclusion, carbamazepine and allopurinol were the leading causative drugs for SJS/TEN in China. Combination of IVIG and steroids is a common treatment for TEN, but its efficacy in improving mortality needs further investigation.http://dx.doi.org/10.1155/2018/4320195 |
| spellingShingle | Shang-Chen Yang Sindy Hu Sheng-Zheng Zhang Jin-wen Huang Jing Zhang Chao Ji Bo Cheng The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China Journal of Immunology Research |
| title | The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China |
| title_full | The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China |
| title_fullStr | The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China |
| title_full_unstemmed | The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China |
| title_short | The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China |
| title_sort | epidemiology of stevens johnson syndrome and toxic epidermal necrolysis in china |
| url | http://dx.doi.org/10.1155/2018/4320195 |
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