Malignant stromal tumor of the stomach with giant cystic liver metastases prior to treatment with imatinib mesylate
Introduction. Gastrointestinal stromal tumors (GISTs) are rare and account for 0.1%-3% of all gastrointestinal neoplasms. GISTs are most commonly located in the stomach (60%) and 20%-25% are malignant, with metastases involving the peritoneum or the liver. Cystic liver metastases are extrem...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2013-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501302225C.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850257628435841024 |
|---|---|
| author | Čolović Radoje Micev Marjan Matić Slavko Čolović Nataša Grubor Nikica Atkinson Dushan Henry |
| author_facet | Čolović Radoje Micev Marjan Matić Slavko Čolović Nataša Grubor Nikica Atkinson Dushan Henry |
| author_sort | Čolović Radoje |
| collection | DOAJ |
| description | Introduction. Gastrointestinal stromal tumors (GISTs) are rare and account
for 0.1%-3% of all gastrointestinal neoplasms. GISTs are most commonly
located in the stomach (60%) and 20%-25% are malignant, with metastases
involving the peritoneum or the liver. Cystic liver metastases are extremely
rare. Only two previous cases of patients with cystic liver metastases,
prior to treatment with imatinib mesylate, have been described so far. Case
report. We reported a 52-year-old woman presented with a history of
abdominal fullness and discomfort. Clinical examination revealed two
palpable masses, first in the right upper abdomen and second left to the
umbilicus. Examinations revealed 4 cystic metastases in the liver, 3 in the
right lobe (including a huge one measuring 20.5 x 16 cm), and 1 in the left
lobe, together with a primary tumor on the greater curvature of the stomach.
Gastric tumor was removed with a Billroth II gastrectomy. Partial excision
of the largest liver metastasis was performed for histopathology.
Immunohistochemistry confirmed the diagnosis of a GIST in both tissue
samples. After an uneventful recovery the patient was commenced on imatinib
mesylate therapy. The patient remainsed symptom-free at 24 months follow-up.
Conclusion. This was the third reported case of gastric GIST with giant
cystic liver metastases present prior to treatment with imatinib mesylate.
Although extremely rare, GISTs may present with cystic liver metastases
prior to treatment with imatinib mesylate, and should be considered in the
differential diagnoses of patients with liver cysts of uncertain aetiology. |
| format | Article |
| id | doaj-art-3fbb07ba67474e098f5bd3d66e567928 |
| institution | OA Journals |
| issn | 0042-8450 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-3fbb07ba67474e098f5bd3d66e5679282025-08-20T01:56:20ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502013-01-0170222522810.2298/VSP1302225C0042-84501302225CMalignant stromal tumor of the stomach with giant cystic liver metastases prior to treatment with imatinib mesylateČolović Radoje0Micev Marjan1Matić Slavko2Čolović Nataša3Grubor Nikica4Atkinson Dushan Henry5Clinical Center of Serbia Clinic for Digestive Surgery, BelgradeClinical Center of Serbia Clinic for Digestive Surgery, BelgradeClinical Center of Serbia Clinic for Digestive Surgery, BelgradeClinical Center of Serbia, Clinic for Hematology, BelgradeClinical Center of Serbia Clinic for Digestive Surgery, BelgradeNorth London Sports Orthopaedics, SOUK and North Middlesex University Hospital, London, United KingdomIntroduction. Gastrointestinal stromal tumors (GISTs) are rare and account for 0.1%-3% of all gastrointestinal neoplasms. GISTs are most commonly located in the stomach (60%) and 20%-25% are malignant, with metastases involving the peritoneum or the liver. Cystic liver metastases are extremely rare. Only two previous cases of patients with cystic liver metastases, prior to treatment with imatinib mesylate, have been described so far. Case report. We reported a 52-year-old woman presented with a history of abdominal fullness and discomfort. Clinical examination revealed two palpable masses, first in the right upper abdomen and second left to the umbilicus. Examinations revealed 4 cystic metastases in the liver, 3 in the right lobe (including a huge one measuring 20.5 x 16 cm), and 1 in the left lobe, together with a primary tumor on the greater curvature of the stomach. Gastric tumor was removed with a Billroth II gastrectomy. Partial excision of the largest liver metastasis was performed for histopathology. Immunohistochemistry confirmed the diagnosis of a GIST in both tissue samples. After an uneventful recovery the patient was commenced on imatinib mesylate therapy. The patient remainsed symptom-free at 24 months follow-up. Conclusion. This was the third reported case of gastric GIST with giant cystic liver metastases present prior to treatment with imatinib mesylate. Although extremely rare, GISTs may present with cystic liver metastases prior to treatment with imatinib mesylate, and should be considered in the differential diagnoses of patients with liver cysts of uncertain aetiology.http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501302225C.pdfgastrointestinal stromal tumorsstomachdiagnosis, differentialliverneoplasm metastasis |
| spellingShingle | Čolović Radoje Micev Marjan Matić Slavko Čolović Nataša Grubor Nikica Atkinson Dushan Henry Malignant stromal tumor of the stomach with giant cystic liver metastases prior to treatment with imatinib mesylate Vojnosanitetski Pregled gastrointestinal stromal tumors stomach diagnosis, differential liver neoplasm metastasis |
| title | Malignant stromal tumor of the stomach with giant cystic liver metastases prior to treatment with imatinib mesylate |
| title_full | Malignant stromal tumor of the stomach with giant cystic liver metastases prior to treatment with imatinib mesylate |
| title_fullStr | Malignant stromal tumor of the stomach with giant cystic liver metastases prior to treatment with imatinib mesylate |
| title_full_unstemmed | Malignant stromal tumor of the stomach with giant cystic liver metastases prior to treatment with imatinib mesylate |
| title_short | Malignant stromal tumor of the stomach with giant cystic liver metastases prior to treatment with imatinib mesylate |
| title_sort | malignant stromal tumor of the stomach with giant cystic liver metastases prior to treatment with imatinib mesylate |
| topic | gastrointestinal stromal tumors stomach diagnosis, differential liver neoplasm metastasis |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501302225C.pdf |
| work_keys_str_mv | AT colovicradoje malignantstromaltumorofthestomachwithgiantcysticlivermetastasespriortotreatmentwithimatinibmesylate AT micevmarjan malignantstromaltumorofthestomachwithgiantcysticlivermetastasespriortotreatmentwithimatinibmesylate AT maticslavko malignantstromaltumorofthestomachwithgiantcysticlivermetastasespriortotreatmentwithimatinibmesylate AT colovicnatasa malignantstromaltumorofthestomachwithgiantcysticlivermetastasespriortotreatmentwithimatinibmesylate AT grubornikica malignantstromaltumorofthestomachwithgiantcysticlivermetastasespriortotreatmentwithimatinibmesylate AT atkinsondushanhenry malignantstromaltumorofthestomachwithgiantcysticlivermetastasespriortotreatmentwithimatinibmesylate |