Advancing Design Strategy of PROTACs for Cancer Therapy

Advancing Design Strategy of PROTACs for Cancer Therapy

ABSTRACT Proteolysis targeting chimeras (PROTACs) have emerged as a groundbreaking class of anticancer therapeutics. These bifunctional molecules harness the endogenous ubiquitin–proteasome system to facilitate the degradation of targeted proteins of interest (POIs). Notably, the clinical translatio...

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Bibliographic Details
Main Authors: Hang Luo, Yuan Tian, Razack Abdullah, Baoting Zhang, Yuan Ma, Ge Zhang
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:MedComm
Subjects:
artificial intelligence
cancer therapy
E3 ligand
linker design
POI ligand
proteolysis targeting chimeras (PROTACs)
Online Access:https://doi.org/10.1002/mco2.70258
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