Unveiling hotspots of emerging research in the miRNA-related mechanism underlying cancer through comprehensive bibliometric analysis with implications for precision medicine and non-invasive diagnostics
Background and objectiveMicroRNAs (miRNAs) are implicated in cancer by exerting roles in tumor growth, metastasis, and even drug resistance. The general trends of miRNA research in diverse cancers are not fully understood. In this work, miRNA-related research in colorectal cancer, prostate cancer, l...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1521251/full |
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| author | Zhirui Zhang Wenhuan Song Wenyu Chen Wenze Cui Wenyi Chen Qinheng Zhang Wenwen Ji Yinglin Wang Jiayi Wang Wenhao Yu Mingkun Yu Mingkun Yu Tao Hao Hong Jiang |
| author_facet | Zhirui Zhang Wenhuan Song Wenyu Chen Wenze Cui Wenyi Chen Qinheng Zhang Wenwen Ji Yinglin Wang Jiayi Wang Wenhao Yu Mingkun Yu Mingkun Yu Tao Hao Hong Jiang |
| author_sort | Zhirui Zhang |
| collection | DOAJ |
| description | Background and objectiveMicroRNAs (miRNAs) are implicated in cancer by exerting roles in tumor growth, metastasis, and even drug resistance. The general trends of miRNA research in diverse cancers are not fully understood. In this work, miRNA-related research in colorectal cancer, prostate cancer, leukemia, and brain tumors was analyzed in search of key research trends with clinical potential.MethodsA bibliometric analysis of articles, spanning from 2014 to 2024, was carried out with the major focus laid on four types of cancers. The Co-citation network analysis, keyword bursts, and the collaborative pattern were done in VOSviewer and CiteSpace, respectively.ResultsColorectal cancer had the highest publication volume, with research primarily focusing on gene expression, extracellular vesicles, and non-coding RNAs. Prostate cancer showed a shift toward clinical applications, while leukemia and brain tumor research, though less extensive, highlighted miRNA’s potential in early diagnosis and treatment. Co-citation analysis identified emerging research collaborations and key contributors.ConclusionmiRNA plays a pivotal role in cancer diagnosis, biomarker development, and therapeutic interventions. With advancements in non-invasive diagnostics and personalized medicine, miRNA offers significant potential for clinical applications. Future research should focus on miRNA’s role in drug resistance and combination therapies to accelerate its clinical translation. |
| format | Article |
| id | doaj-art-3fb8f421d2e9406fbc4866e33bfaf656 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-3fb8f421d2e9406fbc4866e33bfaf6562025-01-15T06:10:48ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.15212511521251Unveiling hotspots of emerging research in the miRNA-related mechanism underlying cancer through comprehensive bibliometric analysis with implications for precision medicine and non-invasive diagnosticsZhirui Zhang0Wenhuan Song1Wenyu Chen2Wenze Cui3Wenyi Chen4Qinheng Zhang5Wenwen Ji6Yinglin Wang7Jiayi Wang8Wenhao Yu9Mingkun Yu10Mingkun Yu11Tao Hao12Hong Jiang13Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, Shandong, ChinaCollege of Traditional Chinese Medicine, Binzhou Medical University, Yantai, Shandong, ChinaCollege of Traditional Chinese Medicine, Binzhou Medical University, Yantai, Shandong, ChinaCollege of Traditional Chinese Medicine, Binzhou Medical University, Yantai, Shandong, ChinaCollege of Traditional Chinese Medicine, Binzhou Medical University, Yantai, Shandong, ChinaCollege of Traditional Chinese Medicine, Binzhou Medical University, Yantai, Shandong, ChinaCollege of Traditional Chinese Medicine, Binzhou Medical University, Yantai, Shandong, ChinaCollege of Traditional Chinese Medicine, Binzhou Medical University, Yantai, Shandong, ChinaCollege of Traditional Chinese Medicine, Binzhou Medical University, Yantai, Shandong, ChinaCollege of Traditional Chinese Medicine, Binzhou Medical University, Yantai, Shandong, ChinaBinzhou Medical College Affiliated Traditional Chinese Medicine Hospital, Binzhou, Shandong, ChinaShandong University of Traditional Chinese Medicine, University Science Park, Jinan, Shandong, ChinaDepartment of Colorectal Hernia Surgery, Binzhou Medical University Hospital, Binzhou, Shandong, ChinaDepartment of Colorectal Hernia Surgery, Binzhou Medical University Hospital, Binzhou, Shandong, ChinaBackground and objectiveMicroRNAs (miRNAs) are implicated in cancer by exerting roles in tumor growth, metastasis, and even drug resistance. The general trends of miRNA research in diverse cancers are not fully understood. In this work, miRNA-related research in colorectal cancer, prostate cancer, leukemia, and brain tumors was analyzed in search of key research trends with clinical potential.MethodsA bibliometric analysis of articles, spanning from 2014 to 2024, was carried out with the major focus laid on four types of cancers. The Co-citation network analysis, keyword bursts, and the collaborative pattern were done in VOSviewer and CiteSpace, respectively.ResultsColorectal cancer had the highest publication volume, with research primarily focusing on gene expression, extracellular vesicles, and non-coding RNAs. Prostate cancer showed a shift toward clinical applications, while leukemia and brain tumor research, though less extensive, highlighted miRNA’s potential in early diagnosis and treatment. Co-citation analysis identified emerging research collaborations and key contributors.ConclusionmiRNA plays a pivotal role in cancer diagnosis, biomarker development, and therapeutic interventions. With advancements in non-invasive diagnostics and personalized medicine, miRNA offers significant potential for clinical applications. Future research should focus on miRNA’s role in drug resistance and combination therapies to accelerate its clinical translation.https://www.frontiersin.org/articles/10.3389/fonc.2024.1521251/fullmicroRNAcancer diagnosisbibliometric analysisnon-invasive diagnosticspersonalized medicine |
| spellingShingle | Zhirui Zhang Wenhuan Song Wenyu Chen Wenze Cui Wenyi Chen Qinheng Zhang Wenwen Ji Yinglin Wang Jiayi Wang Wenhao Yu Mingkun Yu Mingkun Yu Tao Hao Hong Jiang Unveiling hotspots of emerging research in the miRNA-related mechanism underlying cancer through comprehensive bibliometric analysis with implications for precision medicine and non-invasive diagnostics Frontiers in Oncology microRNA cancer diagnosis bibliometric analysis non-invasive diagnostics personalized medicine |
| title | Unveiling hotspots of emerging research in the miRNA-related mechanism underlying cancer through comprehensive bibliometric analysis with implications for precision medicine and non-invasive diagnostics |
| title_full | Unveiling hotspots of emerging research in the miRNA-related mechanism underlying cancer through comprehensive bibliometric analysis with implications for precision medicine and non-invasive diagnostics |
| title_fullStr | Unveiling hotspots of emerging research in the miRNA-related mechanism underlying cancer through comprehensive bibliometric analysis with implications for precision medicine and non-invasive diagnostics |
| title_full_unstemmed | Unveiling hotspots of emerging research in the miRNA-related mechanism underlying cancer through comprehensive bibliometric analysis with implications for precision medicine and non-invasive diagnostics |
| title_short | Unveiling hotspots of emerging research in the miRNA-related mechanism underlying cancer through comprehensive bibliometric analysis with implications for precision medicine and non-invasive diagnostics |
| title_sort | unveiling hotspots of emerging research in the mirna related mechanism underlying cancer through comprehensive bibliometric analysis with implications for precision medicine and non invasive diagnostics |
| topic | microRNA cancer diagnosis bibliometric analysis non-invasive diagnostics personalized medicine |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1521251/full |
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