Prevalence and clinical characteristics of ocular sarcoidosis among non-infectious uveitis in a Chinese tertiary ophthalmic center: a retrospective observational study
Abstract Background The prevalence of ocular sarcoidosis (OS) varies across Asia and the application of the most recent revised diagnostic criteria has not yet been fully adopted. Thus, the prevalence of OS within the Chinese population remains uncertain. We investigate the prevalence of OS among no...
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2025-07-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-025-04165-x |
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| author | Daquan He Tianyu Tao Xuening Peng Jianjie Lv Wenru Su |
| author_facet | Daquan He Tianyu Tao Xuening Peng Jianjie Lv Wenru Su |
| author_sort | Daquan He |
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| description | Abstract Background The prevalence of ocular sarcoidosis (OS) varies across Asia and the application of the most recent revised diagnostic criteria has not yet been fully adopted. Thus, the prevalence of OS within the Chinese population remains uncertain. We investigate the prevalence of OS among non-infectious uveitis in China, with the Revised criteria of International Workshop on OS. Methods In this study, we retrospectively reviewed the medical records of 406 patients who had undergone routine computed tomography scans between May 2019 and June 2023. The diagnosis of OS was made according to the Revised criteria of International Workshop on Ocular Sarcoidosis (IWOS). We further reviewed the clinical characteristics of four patients, including age, gender, anatomical type of uveitis, ocular manifestations, ocular examinations, visual acuity, and complications. Results Out of 254 patients with noninfectious uveitis who completed computed tomography, 138 (54.3%) were men, and 116 (45.6%) were women, with a mean age of 38.9 years (ranging from 6 to 77 years). Among the 254 patients with non-infectious uveitis, OS accounted for 1.57% of the cases, however, Behcet’s disease (14.5%) was the predominant etiology, followed by Vogt-Koyanagi-Harada disease (12.9%), retinal vasculitis (1.1%), multifocal choroiditis (1.1%), sympathetic ophthalmia (1.1%), punctate inner choroidopathy (0.7%), and acute posterior multifocal placoid pigment epitheliopathy (0.3%). The study revealed that 3 patients were diagnosed with definite OS, and 1 had presumed OS. Among 406 patients who underwent computed tomography, 0.98% (4/406) of patients met the Revised criteria of IWOS, 1.37% (4/290) of patients with uveitis, and 1.57% (4/254) of patients among non-infectious uveitis. Conclusions This study determined the prevalence of OS among non-infectious uveitis in China, and described the clinical characteristics of four individuals. |
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| institution | DOAJ |
| issn | 1471-2415 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | BMC Ophthalmology |
| spelling | doaj-art-3fb82f1c9b8a4fb6a6a03c7d71280fbd2025-08-20T03:03:34ZengBMCBMC Ophthalmology1471-24152025-07-012511910.1186/s12886-025-04165-xPrevalence and clinical characteristics of ocular sarcoidosis among non-infectious uveitis in a Chinese tertiary ophthalmic center: a retrospective observational studyDaquan He0Tianyu Tao1Xuening Peng2Jianjie Lv3Wenru Su4State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen UniversityDepartment of Ophthalmology, The Second Affiliated Hospital, Guangzhou Medical UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen UniversityDepartment of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineAbstract Background The prevalence of ocular sarcoidosis (OS) varies across Asia and the application of the most recent revised diagnostic criteria has not yet been fully adopted. Thus, the prevalence of OS within the Chinese population remains uncertain. We investigate the prevalence of OS among non-infectious uveitis in China, with the Revised criteria of International Workshop on OS. Methods In this study, we retrospectively reviewed the medical records of 406 patients who had undergone routine computed tomography scans between May 2019 and June 2023. The diagnosis of OS was made according to the Revised criteria of International Workshop on Ocular Sarcoidosis (IWOS). We further reviewed the clinical characteristics of four patients, including age, gender, anatomical type of uveitis, ocular manifestations, ocular examinations, visual acuity, and complications. Results Out of 254 patients with noninfectious uveitis who completed computed tomography, 138 (54.3%) were men, and 116 (45.6%) were women, with a mean age of 38.9 years (ranging from 6 to 77 years). Among the 254 patients with non-infectious uveitis, OS accounted for 1.57% of the cases, however, Behcet’s disease (14.5%) was the predominant etiology, followed by Vogt-Koyanagi-Harada disease (12.9%), retinal vasculitis (1.1%), multifocal choroiditis (1.1%), sympathetic ophthalmia (1.1%), punctate inner choroidopathy (0.7%), and acute posterior multifocal placoid pigment epitheliopathy (0.3%). The study revealed that 3 patients were diagnosed with definite OS, and 1 had presumed OS. Among 406 patients who underwent computed tomography, 0.98% (4/406) of patients met the Revised criteria of IWOS, 1.37% (4/290) of patients with uveitis, and 1.57% (4/254) of patients among non-infectious uveitis. Conclusions This study determined the prevalence of OS among non-infectious uveitis in China, and described the clinical characteristics of four individuals.https://doi.org/10.1186/s12886-025-04165-xOcular sarcoidosisNon-infectious uveitisComputed tomographyPrevalenceChina |
| spellingShingle | Daquan He Tianyu Tao Xuening Peng Jianjie Lv Wenru Su Prevalence and clinical characteristics of ocular sarcoidosis among non-infectious uveitis in a Chinese tertiary ophthalmic center: a retrospective observational study BMC Ophthalmology Ocular sarcoidosis Non-infectious uveitis Computed tomography Prevalence China |
| title | Prevalence and clinical characteristics of ocular sarcoidosis among non-infectious uveitis in a Chinese tertiary ophthalmic center: a retrospective observational study |
| title_full | Prevalence and clinical characteristics of ocular sarcoidosis among non-infectious uveitis in a Chinese tertiary ophthalmic center: a retrospective observational study |
| title_fullStr | Prevalence and clinical characteristics of ocular sarcoidosis among non-infectious uveitis in a Chinese tertiary ophthalmic center: a retrospective observational study |
| title_full_unstemmed | Prevalence and clinical characteristics of ocular sarcoidosis among non-infectious uveitis in a Chinese tertiary ophthalmic center: a retrospective observational study |
| title_short | Prevalence and clinical characteristics of ocular sarcoidosis among non-infectious uveitis in a Chinese tertiary ophthalmic center: a retrospective observational study |
| title_sort | prevalence and clinical characteristics of ocular sarcoidosis among non infectious uveitis in a chinese tertiary ophthalmic center a retrospective observational study |
| topic | Ocular sarcoidosis Non-infectious uveitis Computed tomography Prevalence China |
| url | https://doi.org/10.1186/s12886-025-04165-x |
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