Antimicrobial Peptides: A Promising Solution to the Rising Threat of Antibiotic Resistance
The demand for developing novel antimicrobial drugs has increased due to the rapid appearance and global spread of antibiotic resistance. Antimicrobial peptides (AMPs) offer distinct advantages over traditional antibiotics, such as broad-range efficacy, a delayed evolution of resistance, and the cap...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/12/1542 |
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| author | Tarequl Islam Noshin Tabassum Tamanna Md Shahjalal Sagor Randa Mohammed Zaki Muhammad Fazle Rabbee Maximilian Lackner |
| author_facet | Tarequl Islam Noshin Tabassum Tamanna Md Shahjalal Sagor Randa Mohammed Zaki Muhammad Fazle Rabbee Maximilian Lackner |
| author_sort | Tarequl Islam |
| collection | DOAJ |
| description | The demand for developing novel antimicrobial drugs has increased due to the rapid appearance and global spread of antibiotic resistance. Antimicrobial peptides (AMPs) offer distinct advantages over traditional antibiotics, such as broad-range efficacy, a delayed evolution of resistance, and the capacity to enhance human immunity. AMPs are being developed as potential medicines, and current computational and experimental tools aim to facilitate their preclinical and clinical development. Structural and functional constraints as well as a more stringent regulatory framework have impeded clinical translation of AMPs as possible therapeutic agents. Although around four thousand AMPs have been identified so far, there are some limitations of using these AMPs in clinical trials due to their safety in the host and sometimes limitations in the biosynthesis or chemical synthesis of some AMPs. Overcoming these obstacles may help to open a new era of AMPs to combat superbugs without using synthetic antibiotics. This review describes the classification, mechanisms of action and immune modulation, advantages, difficulties, and opportunities of using AMPs against multidrug-resistant pathogens and highlights the need and priorities for creating targeted development strategies that take into account the most cutting-edge tools currently available. It also describes the barriers to using these AMPs in clinical trials. |
| format | Article |
| id | doaj-art-3fb6ecc77ee24be3a2f5b41eb689ba12 |
| institution | DOAJ |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-3fb6ecc77ee24be3a2f5b41eb689ba122025-08-20T02:43:39ZengMDPI AGPharmaceutics1999-49232024-12-011612154210.3390/pharmaceutics16121542Antimicrobial Peptides: A Promising Solution to the Rising Threat of Antibiotic ResistanceTarequl Islam0Noshin Tabassum Tamanna1Md Shahjalal Sagor2Randa Mohammed Zaki3Muhammad Fazle Rabbee4Maximilian Lackner5Department of Microbiology, Noakhali Science and Technology University, Sonapur, Noakhali 3814, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, BangladeshDepartment of Microbiology, Jagannath University, Dhaka 1100, BangladeshDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi ArabiaDepartment of Biotechnology, Yeungnam University, Gyeongsan 38541, Gyeongbuk, Republic of KoreaDepartment of Industrial Engineering, University of Applied Sciences Technikum Wien, Hoechstaedtplatz 6, 1200 Vienna, AustriaThe demand for developing novel antimicrobial drugs has increased due to the rapid appearance and global spread of antibiotic resistance. Antimicrobial peptides (AMPs) offer distinct advantages over traditional antibiotics, such as broad-range efficacy, a delayed evolution of resistance, and the capacity to enhance human immunity. AMPs are being developed as potential medicines, and current computational and experimental tools aim to facilitate their preclinical and clinical development. Structural and functional constraints as well as a more stringent regulatory framework have impeded clinical translation of AMPs as possible therapeutic agents. Although around four thousand AMPs have been identified so far, there are some limitations of using these AMPs in clinical trials due to their safety in the host and sometimes limitations in the biosynthesis or chemical synthesis of some AMPs. Overcoming these obstacles may help to open a new era of AMPs to combat superbugs without using synthetic antibiotics. This review describes the classification, mechanisms of action and immune modulation, advantages, difficulties, and opportunities of using AMPs against multidrug-resistant pathogens and highlights the need and priorities for creating targeted development strategies that take into account the most cutting-edge tools currently available. It also describes the barriers to using these AMPs in clinical trials.https://www.mdpi.com/1999-4923/16/12/1542peptide antibioticsmicroorganismsmulti-drug resistancetherapeuticspeptide design |
| spellingShingle | Tarequl Islam Noshin Tabassum Tamanna Md Shahjalal Sagor Randa Mohammed Zaki Muhammad Fazle Rabbee Maximilian Lackner Antimicrobial Peptides: A Promising Solution to the Rising Threat of Antibiotic Resistance Pharmaceutics peptide antibiotics microorganisms multi-drug resistance therapeutics peptide design |
| title | Antimicrobial Peptides: A Promising Solution to the Rising Threat of Antibiotic Resistance |
| title_full | Antimicrobial Peptides: A Promising Solution to the Rising Threat of Antibiotic Resistance |
| title_fullStr | Antimicrobial Peptides: A Promising Solution to the Rising Threat of Antibiotic Resistance |
| title_full_unstemmed | Antimicrobial Peptides: A Promising Solution to the Rising Threat of Antibiotic Resistance |
| title_short | Antimicrobial Peptides: A Promising Solution to the Rising Threat of Antibiotic Resistance |
| title_sort | antimicrobial peptides a promising solution to the rising threat of antibiotic resistance |
| topic | peptide antibiotics microorganisms multi-drug resistance therapeutics peptide design |
| url | https://www.mdpi.com/1999-4923/16/12/1542 |
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