From Chronic Use of Minocycline to Pigmented Unicuspid Aortic Valve: A Unique Single Case
We discuss the case of a 47-year-old female who presented to our institution with progressive exertional shortness of breath. Her history was notable for severe acne medicated with 100 mg oral daily minocycline for 2 years and a presumptive diagnosis of a bicuspid aortic valve. Investigations reveal...
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| Format: | Article |
| Language: | English |
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Houston Methodist DeBakey Heart & Vascular Center
2025-03-01
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| Series: | Methodist DeBakey Cardiovascular Journal |
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| Online Access: | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1564 |
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| author | Nour B. Odeh Juan M. Farina Pete J. Manchen Kristen A. Sell-Dottin Bryan Barrus |
| author_facet | Nour B. Odeh Juan M. Farina Pete J. Manchen Kristen A. Sell-Dottin Bryan Barrus |
| author_sort | Nour B. Odeh |
| collection | DOAJ |
| description | We discuss the case of a 47-year-old female who presented to our institution with progressive exertional shortness of breath. Her history was notable for severe acne medicated with 100 mg oral daily minocycline for 2 years and a presumptive diagnosis of a bicuspid aortic valve. Investigations revealed severe aortic stenosis, prompting a decision for elective aortic valve repair. Intraoperatively, significant calcification of a unicuspid aortic valve, atypically blackened valve, and endocardium of the left ventricle and aorta were visualized. |
| format | Article |
| id | doaj-art-3fb6d6422a254b63a18759ae191c28bc |
| institution | Kabale University |
| issn | 1947-6108 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Houston Methodist DeBakey Heart & Vascular Center |
| record_format | Article |
| series | Methodist DeBakey Cardiovascular Journal |
| spelling | doaj-art-3fb6d6422a254b63a18759ae191c28bc2025-08-20T03:25:30ZengHouston Methodist DeBakey Heart & Vascular CenterMethodist DeBakey Cardiovascular Journal1947-61082025-03-01211303410.14797/mdcvj.15641542From Chronic Use of Minocycline to Pigmented Unicuspid Aortic Valve: A Unique Single CaseNour B. Odeh0https://orcid.org/0000-0002-9036-9906Juan M. Farina1https://orcid.org/0000-0002-5824-8485Pete J. Manchen2https://orcid.org/0009-0005-5020-6810Kristen A. Sell-Dottin3https://orcid.org/0000-0001-5933-3537Bryan Barrus4https://orcid.org/0000-0003-3959-8268Mayo Clinic, Phoenix, ArizonaMayo Clinic, Phoenix, ArizonaMayo Clinic, Phoenix, ArizonaMayo Clinic, Phoenix, ArizonaMayo Clinic, Phoenix, ArizonaWe discuss the case of a 47-year-old female who presented to our institution with progressive exertional shortness of breath. Her history was notable for severe acne medicated with 100 mg oral daily minocycline for 2 years and a presumptive diagnosis of a bicuspid aortic valve. Investigations revealed severe aortic stenosis, prompting a decision for elective aortic valve repair. Intraoperatively, significant calcification of a unicuspid aortic valve, atypically blackened valve, and endocardium of the left ventricle and aorta were visualized.https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1564minocyclineminocycline induced hyperpigmentation (mih)alkaptonuriacardiovascular hyperpigmentationvalvular pigmentationaortic stenosiscardiovascular ochronosis |
| spellingShingle | Nour B. Odeh Juan M. Farina Pete J. Manchen Kristen A. Sell-Dottin Bryan Barrus From Chronic Use of Minocycline to Pigmented Unicuspid Aortic Valve: A Unique Single Case Methodist DeBakey Cardiovascular Journal minocycline minocycline induced hyperpigmentation (mih) alkaptonuria cardiovascular hyperpigmentation valvular pigmentation aortic stenosis cardiovascular ochronosis |
| title | From Chronic Use of Minocycline to Pigmented Unicuspid Aortic Valve: A Unique Single Case |
| title_full | From Chronic Use of Minocycline to Pigmented Unicuspid Aortic Valve: A Unique Single Case |
| title_fullStr | From Chronic Use of Minocycline to Pigmented Unicuspid Aortic Valve: A Unique Single Case |
| title_full_unstemmed | From Chronic Use of Minocycline to Pigmented Unicuspid Aortic Valve: A Unique Single Case |
| title_short | From Chronic Use of Minocycline to Pigmented Unicuspid Aortic Valve: A Unique Single Case |
| title_sort | from chronic use of minocycline to pigmented unicuspid aortic valve a unique single case |
| topic | minocycline minocycline induced hyperpigmentation (mih) alkaptonuria cardiovascular hyperpigmentation valvular pigmentation aortic stenosis cardiovascular ochronosis |
| url | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1564 |
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