Chlamydia and mitochondria – an unfragmented relationship
Presence of pathogens within a eukaryotic cell is apt to generate stress. Such stress eventually leads to host defense responses, which includes, but is not limited to, apoptosis induction and subsequent destruction of the host cell and the pathogen. Obligate intracellular pathogens such as Chlamydi...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shared Science Publishers OG
2017-06-01
|
| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/chlamydia-and-mitochondria-an-unfragmented-relationship/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850228403737722880 |
|---|---|
| author | Suvagata Roy Chowdhury Thomas Rudel |
| author_facet | Suvagata Roy Chowdhury Thomas Rudel |
| author_sort | Suvagata Roy Chowdhury |
| collection | DOAJ |
| description | Presence of pathogens within a eukaryotic cell is apt to generate stress. Such stress eventually leads to host defense responses, which includes, but is not limited to, apoptosis induction and subsequent destruction of the host cell and the pathogen. Obligate intracellular pathogens such as Chlamydia trachomatis are dependent on the survival of the host cell owing to their unique replication niche within a membrane-bound inclusion. Furthermore, being energy parasites, chlamydial development is strictly dependent on the host metabolism. Over the past decade the role of the small non-coding RNAs called microRNAs (miRNAs) have come into focus with respect to the regulation of apoptotic signaling, metabolic homeostasis and bacterial pathogenesis. Effect of Chlamydia infection on the host miRNA profile was hitherto unknown. In our recent work we demonstrated that Chlamydia infection induces and requires an upregulation of the host miRNA, miR-30c-5p (miR-30c) to ameliorate infection induced stress on the host mitochondrial architecture and hinders induction of apoptosis. |
| format | Article |
| id | doaj-art-3fb562dcf2db47e38f3bd56b90a52f4f |
| institution | OA Journals |
| issn | 2311-2638 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-3fb562dcf2db47e38f3bd56b90a52f4f2025-08-20T02:04:33ZengShared Science Publishers OGMicrobial Cell2311-26382017-06-014723323510.15698/mic2017.07.582Chlamydia and mitochondria – an unfragmented relationshipSuvagata Roy Chowdhury0Thomas Rudel1Department of Microbiology, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany.Department of Microbiology, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany.Presence of pathogens within a eukaryotic cell is apt to generate stress. Such stress eventually leads to host defense responses, which includes, but is not limited to, apoptosis induction and subsequent destruction of the host cell and the pathogen. Obligate intracellular pathogens such as Chlamydia trachomatis are dependent on the survival of the host cell owing to their unique replication niche within a membrane-bound inclusion. Furthermore, being energy parasites, chlamydial development is strictly dependent on the host metabolism. Over the past decade the role of the small non-coding RNAs called microRNAs (miRNAs) have come into focus with respect to the regulation of apoptotic signaling, metabolic homeostasis and bacterial pathogenesis. Effect of Chlamydia infection on the host miRNA profile was hitherto unknown. In our recent work we demonstrated that Chlamydia infection induces and requires an upregulation of the host miRNA, miR-30c-5p (miR-30c) to ameliorate infection induced stress on the host mitochondrial architecture and hinders induction of apoptosis.http://microbialcell.com/researcharticles/chlamydia-and-mitochondria-an-unfragmented-relationship/ChlamydiamitochondriametabolismmiRNA |
| spellingShingle | Suvagata Roy Chowdhury Thomas Rudel Chlamydia and mitochondria – an unfragmented relationship Microbial Cell Chlamydia mitochondria metabolism miRNA |
| title | Chlamydia and mitochondria – an unfragmented relationship |
| title_full | Chlamydia and mitochondria – an unfragmented relationship |
| title_fullStr | Chlamydia and mitochondria – an unfragmented relationship |
| title_full_unstemmed | Chlamydia and mitochondria – an unfragmented relationship |
| title_short | Chlamydia and mitochondria – an unfragmented relationship |
| title_sort | chlamydia and mitochondria an unfragmented relationship |
| topic | Chlamydia mitochondria metabolism miRNA |
| url | http://microbialcell.com/researcharticles/chlamydia-and-mitochondria-an-unfragmented-relationship/ |
| work_keys_str_mv | AT suvagataroychowdhury chlamydiaandmitochondriaanunfragmentedrelationship AT thomasrudel chlamydiaandmitochondriaanunfragmentedrelationship |