Physical-chemical properties of 2-((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazol-3-il)tio)-1-arylethanons and their reduced systems
The aim of work is the investigation of properties of 2-((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazol-3-yl)thio)-1-arylethanones and 2((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazol-3-yl)thio)-1-arylethanols using modern physical-chemical methods.Materials and methods. Modern physical-chemical studies of 2-...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2019-07-01
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| Series: | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
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| Online Access: | http://pharmed.zsmu.edu.ua/article/view/170972/172658 |
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| Summary: | The aim of work is the investigation of properties of 2-((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazol-3-yl)thio)-1-arylethanones and 2((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazol-3-yl)thio)-1-arylethanols using modern physical-chemical methods.Materials and methods. Modern physical-chemical studies of 2-((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazol-3-yl)thio)-1-arylethanones and 2-((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazol-3-yl)thio)-1-arylethanols was conducted on certified and licensed equipment of the physical-chemical laboratories of the Zaporizhzhia State Medical University in accordance with approved research plans. As starting compounds for the synthesis of the corresponding 2-((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazol-3-yl)thio)-1-arylethanones, we used 5-(3-fluorophenyl)-4-methyl-1,2,4-triazol-3-thiol, 5(4-fluorophenyl)-4-methyl-1,2,4-triazol-3-thiol, 5(3-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol and 5-(4-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol.Results. The research objects of our choice are promising not only as end compounds for the search of biologically active molecules, they can later be used as starting materials for subsequent chemical transformations. It is also known that the presence of keto-group causes the appearance of different types of pharmacological activity, and the transition to alcohols reduces toxicity.According to the results of the experiment a number of new compounds, which were not previously described in the literature, have been obtained, as well as physical-chemical constants have been given.Conclusions. The reactions of 5-(3-fluorophenyl)-4-methyl-1,2,4-triazole-3-thiol, 5-(4-fluorophenyl)-4-methyl-1,2,4-triazole-3-thiol, 5-(3-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol and 5-(4-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol with some (2-bromo-1-phenylethanone, 2-bromo-1-(2-bromophenyl)ethanone, 2-bromo-1- (2-, 3-, 4-fluorophenyl)ethanone and 2-bromo-1- ( 4-methoxyphenyl)ethanone), a series of novel 2 - ((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazol-3-yl) thio)-1-arylethanones were synthesized. A new series of 2-((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazol-3-yl)thio)-1-aryl-ethanols were synthesized in the experiment. |
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| ISSN: | 2306-8094 2409-2932 |