A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration
Enhancement of the transdermal penetration of different active agents is an important research goal. Our aim was to establish a novel in vivo experimental model which provides a possibility for exact measurement of the quantity of penetrated drug. The experiments were performed on SKH-1 hairless mic...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/543536 |
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| author | Gábor Eros Petra Hartmann Szilvia Berkó Eszter Csizmazia Erzsébet Csányi Anita Sztojkov-Ivanov István Németh Piroska Szabó-Révész István Zupkó Lajos Kemény |
| author_facet | Gábor Eros Petra Hartmann Szilvia Berkó Eszter Csizmazia Erzsébet Csányi Anita Sztojkov-Ivanov István Németh Piroska Szabó-Révész István Zupkó Lajos Kemény |
| author_sort | Gábor Eros |
| collection | DOAJ |
| description | Enhancement of the transdermal penetration of different active agents is an important research goal. Our aim was to establish a novel in vivo experimental model which provides a possibility for exact measurement of the quantity of penetrated drug. The experiments were performed on SKH-1 hairless mice. A skin fold in the dorsal region was fixed with two fenestrated titanium plates. A circular wound was made on one side of the skin fold. A metal cylinder with phosphate buffer was fixed into the window of the titanium plate. The concentration of penetrated drug was measured in the buffer. The skin fold was morphologically intact and had a healthy microcirculation. The drug appeared in the acceptor buffer after 30 min, and its concentration exhibited a continuous increase. The presence of ibuprofen was also detected in the plasma. In conclusion, this model allows an exact in vivo study of drug penetration and absorption. |
| format | Article |
| id | doaj-art-3faaaa4d9b8d404686b22ce768ec5e43 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-3faaaa4d9b8d404686b22ce768ec5e432025-02-03T06:01:09ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/543536543536A Novel Murine Model for the In Vivo Study of Transdermal Drug PenetrationGábor Eros0Petra Hartmann1Szilvia Berkó2Eszter Csizmazia3Erzsébet Csányi4Anita Sztojkov-Ivanov5István Németh6Piroska Szabó-Révész7István Zupkó8Lajos Kemény9Department of Dermatology and Allergology, University of Szeged, 6720 Szeged, HungaryInstitute of Surgical Research, University of Szeged, 6720 Szeged, HungaryDepartment of Pharmaceutical Technology, University of Szeged, 6720 Szeged, HungaryDepartment of Pharmaceutical Technology, University of Szeged, 6720 Szeged, HungaryDepartment of Pharmaceutical Technology, University of Szeged, 6720 Szeged, HungaryDepartment of Pharmacodynamics and Biopharmacy, University of Szeged, 6720 Szeged, HungaryDepartment of Dermatology and Allergology, University of Szeged, 6720 Szeged, HungaryDepartment of Pharmaceutical Technology, University of Szeged, 6720 Szeged, HungaryDepartment of Pharmacodynamics and Biopharmacy, University of Szeged, 6720 Szeged, HungaryDepartment of Dermatology and Allergology, University of Szeged, 6720 Szeged, HungaryEnhancement of the transdermal penetration of different active agents is an important research goal. Our aim was to establish a novel in vivo experimental model which provides a possibility for exact measurement of the quantity of penetrated drug. The experiments were performed on SKH-1 hairless mice. A skin fold in the dorsal region was fixed with two fenestrated titanium plates. A circular wound was made on one side of the skin fold. A metal cylinder with phosphate buffer was fixed into the window of the titanium plate. The concentration of penetrated drug was measured in the buffer. The skin fold was morphologically intact and had a healthy microcirculation. The drug appeared in the acceptor buffer after 30 min, and its concentration exhibited a continuous increase. The presence of ibuprofen was also detected in the plasma. In conclusion, this model allows an exact in vivo study of drug penetration and absorption.http://dx.doi.org/10.1100/2012/543536 |
| spellingShingle | Gábor Eros Petra Hartmann Szilvia Berkó Eszter Csizmazia Erzsébet Csányi Anita Sztojkov-Ivanov István Németh Piroska Szabó-Révész István Zupkó Lajos Kemény A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration The Scientific World Journal |
| title | A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration |
| title_full | A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration |
| title_fullStr | A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration |
| title_full_unstemmed | A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration |
| title_short | A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration |
| title_sort | novel murine model for the in vivo study of transdermal drug penetration |
| url | http://dx.doi.org/10.1100/2012/543536 |
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