Primary sensory neuron dysfunction underlying mechanical itch hypersensitivity in a Shank3 mouse model of autism

Primary sensory neuron dysfunction underlying mechanical itch hypersensitivity in a Shank3 mouse model of autism

Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder marked by social deficits, repetitive behaviors and atypical sensory perception. The link between ASD and skin abnormalities, inducing itchiness, has never been investigated in depth. This study explores mechanical itch sensiti...

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Main Authors: Damien Huzard, Giulia Oliva, Mélanie Marias, Chloé Granat, Vanessa Soubeyre, Glaécia do Nascimento Pereira, Ahmed Negm, Gawain Grellier, Jérôme Devaux, Emmanuel Bourinet, Amaury François
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03461-w
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