Targeting PGK1: A New Frontier in Breast Cancer Therapy Under Hypoxic Conditions
Breast cancer represents one of the most prevalent malignant neoplasms affecting women, and its pathogenesis has garnered significant scholarly interest. Research indicates that the progression of breast cancer is intricately regulated by glucose metabolism. Under hypoxic conditions within the tumor...
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MDPI AG
2024-10-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/46/11/725 |
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| author | Jiayong Cui Shengjun Chai Rui Liu Guoshuang Shen |
| author_facet | Jiayong Cui Shengjun Chai Rui Liu Guoshuang Shen |
| author_sort | Jiayong Cui |
| collection | DOAJ |
| description | Breast cancer represents one of the most prevalent malignant neoplasms affecting women, and its pathogenesis has garnered significant scholarly interest. Research indicates that the progression of breast cancer is intricately regulated by glucose metabolism. Under hypoxic conditions within the tumor microenvironment, breast cancer cells generate ATP and essential biosynthetic precursors for growth via the glycolytic pathway. Notably, phosphoglycerate kinase 1 (PGK1) is intimately associated with the regulation of hypoxia-inducible factors in breast cancer and plays a crucial role in modulating glycolytic processes. Further investigation into the role of PGK1 in breast cancer pathogenesis is anticipated to identify novel therapeutic targets and strategies. This review consolidates current research on the regulation of glucose metabolism and the function of PGK1 in breast cancer within hypoxic conditions. It aims to offer a significant theoretical foundation for elucidating the mechanisms underlying breast cancer progression and metastasis, thereby facilitating the development of innovative treatment approaches. |
| format | Article |
| id | doaj-art-3fa6d5253d1a4d8cbe0a3fef443d6b64 |
| institution | OA Journals |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj-art-3fa6d5253d1a4d8cbe0a3fef443d6b642025-08-20T02:08:03ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452024-10-014611122141222910.3390/cimb46110725Targeting PGK1: A New Frontier in Breast Cancer Therapy Under Hypoxic ConditionsJiayong Cui0Shengjun Chai1Rui Liu2Guoshuang Shen3Clinical Medicine College, Graduate School of Qinghai University, Xining 810000, ChinaClinical Medicine College, Graduate School of Qinghai University, Xining 810000, ChinaClinical Medicine College, Graduate School of Qinghai University, Xining 810000, ChinaBreast Disease Diagnosis and Treatment Cencer, Affiliated Hospital of Qinghai University, Xining 810000, ChinaBreast cancer represents one of the most prevalent malignant neoplasms affecting women, and its pathogenesis has garnered significant scholarly interest. Research indicates that the progression of breast cancer is intricately regulated by glucose metabolism. Under hypoxic conditions within the tumor microenvironment, breast cancer cells generate ATP and essential biosynthetic precursors for growth via the glycolytic pathway. Notably, phosphoglycerate kinase 1 (PGK1) is intimately associated with the regulation of hypoxia-inducible factors in breast cancer and plays a crucial role in modulating glycolytic processes. Further investigation into the role of PGK1 in breast cancer pathogenesis is anticipated to identify novel therapeutic targets and strategies. This review consolidates current research on the regulation of glucose metabolism and the function of PGK1 in breast cancer within hypoxic conditions. It aims to offer a significant theoretical foundation for elucidating the mechanisms underlying breast cancer progression and metastasis, thereby facilitating the development of innovative treatment approaches.https://www.mdpi.com/1467-3045/46/11/725breast cancerhypoxiaHIF-1αglycolysisPGK1 |
| spellingShingle | Jiayong Cui Shengjun Chai Rui Liu Guoshuang Shen Targeting PGK1: A New Frontier in Breast Cancer Therapy Under Hypoxic Conditions Current Issues in Molecular Biology breast cancer hypoxia HIF-1α glycolysis PGK1 |
| title | Targeting PGK1: A New Frontier in Breast Cancer Therapy Under Hypoxic Conditions |
| title_full | Targeting PGK1: A New Frontier in Breast Cancer Therapy Under Hypoxic Conditions |
| title_fullStr | Targeting PGK1: A New Frontier in Breast Cancer Therapy Under Hypoxic Conditions |
| title_full_unstemmed | Targeting PGK1: A New Frontier in Breast Cancer Therapy Under Hypoxic Conditions |
| title_short | Targeting PGK1: A New Frontier in Breast Cancer Therapy Under Hypoxic Conditions |
| title_sort | targeting pgk1 a new frontier in breast cancer therapy under hypoxic conditions |
| topic | breast cancer hypoxia HIF-1α glycolysis PGK1 |
| url | https://www.mdpi.com/1467-3045/46/11/725 |
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