Estimation of Renal Resistive Index as an Early Marker of Diabetic Nephropathy
Background: Diabetic nephropathy (DN) occurs due to angiopathy of glomerular capillaries, which alters the compliance and resistance of the vessel wall. This can be measured with the renal resistive index (RI) using renal Doppler, indicating disease progression. Aims and Objectives: This study aimed...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-07-01
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| Series: | APIK Journal of Internal Medicine |
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| Online Access: | https://journals.lww.com/10.4103/ajim.ajim_70_24 |
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| author | Kushal Markanday Periyapattana Gopinath Kumar Buvana Radhakrishnan Sheeba Rafath |
| author_facet | Kushal Markanday Periyapattana Gopinath Kumar Buvana Radhakrishnan Sheeba Rafath |
| author_sort | Kushal Markanday |
| collection | DOAJ |
| description | Background:
Diabetic nephropathy (DN) occurs due to angiopathy of glomerular capillaries, which alters the compliance and resistance of the vessel wall. This can be measured with the renal resistive index (RI) using renal Doppler, indicating disease progression.
Aims and Objectives:
This study aimed to assess the utility of RI in type 2 diabetes mellitus and to study the association between RI and DN and other complications.
Materials and Methods:
One hundred diabetic patients, 50 each with and without nephropathy, alongside 50 nondiabetics (controls) were included. All 100 cases were assessed for RI, glycemic control, and diabetic complications. RI was also evaluated for the 50 nondiabetic controls.
Results:
RI was higher in patients with macroalbuminuria (0.661 ± 0.04) compared to patients without microalbuminuria (0.58 ± 0.05), and there was a progressive increase in RI with the progression of diabetic renal disease; hence, it had an inverse relation with estimated glomerular filtration rate eGFR.
Conclusions:
Albuminuria and eGFR influence RI, and it rises among people with diabetes (with or without DN) even before the onset of raised creatinine levels. Hence, Baseline estimation of the RI as a marker of intra-renal vascular resistance can be an additional diagnostic tool for diabetic nephropathy. |
| format | Article |
| id | doaj-art-3fa29864fc0c45f6a803536c615a132c |
| institution | Kabale University |
| issn | 2666-1802 2666-1810 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | APIK Journal of Internal Medicine |
| spelling | doaj-art-3fa29864fc0c45f6a803536c615a132c2025-08-20T03:31:41ZengWolters Kluwer Medknow PublicationsAPIK Journal of Internal Medicine2666-18022666-18102025-07-0113320520910.4103/ajim.ajim_70_24Estimation of Renal Resistive Index as an Early Marker of Diabetic NephropathyKushal MarkandayPeriyapattana Gopinath KumarBuvana RadhakrishnanSheeba RafathBackground: Diabetic nephropathy (DN) occurs due to angiopathy of glomerular capillaries, which alters the compliance and resistance of the vessel wall. This can be measured with the renal resistive index (RI) using renal Doppler, indicating disease progression. Aims and Objectives: This study aimed to assess the utility of RI in type 2 diabetes mellitus and to study the association between RI and DN and other complications. Materials and Methods: One hundred diabetic patients, 50 each with and without nephropathy, alongside 50 nondiabetics (controls) were included. All 100 cases were assessed for RI, glycemic control, and diabetic complications. RI was also evaluated for the 50 nondiabetic controls. Results: RI was higher in patients with macroalbuminuria (0.661 ± 0.04) compared to patients without microalbuminuria (0.58 ± 0.05), and there was a progressive increase in RI with the progression of diabetic renal disease; hence, it had an inverse relation with estimated glomerular filtration rate eGFR. Conclusions: Albuminuria and eGFR influence RI, and it rises among people with diabetes (with or without DN) even before the onset of raised creatinine levels. Hence, Baseline estimation of the RI as a marker of intra-renal vascular resistance can be an additional diagnostic tool for diabetic nephropathy.https://journals.lww.com/10.4103/ajim.ajim_70_24diabetic nephropathyestimated glomerular filtration raterenal resistivity |
| spellingShingle | Kushal Markanday Periyapattana Gopinath Kumar Buvana Radhakrishnan Sheeba Rafath Estimation of Renal Resistive Index as an Early Marker of Diabetic Nephropathy APIK Journal of Internal Medicine diabetic nephropathy estimated glomerular filtration rate renal resistivity |
| title | Estimation of Renal Resistive Index as an Early Marker of Diabetic Nephropathy |
| title_full | Estimation of Renal Resistive Index as an Early Marker of Diabetic Nephropathy |
| title_fullStr | Estimation of Renal Resistive Index as an Early Marker of Diabetic Nephropathy |
| title_full_unstemmed | Estimation of Renal Resistive Index as an Early Marker of Diabetic Nephropathy |
| title_short | Estimation of Renal Resistive Index as an Early Marker of Diabetic Nephropathy |
| title_sort | estimation of renal resistive index as an early marker of diabetic nephropathy |
| topic | diabetic nephropathy estimated glomerular filtration rate renal resistivity |
| url | https://journals.lww.com/10.4103/ajim.ajim_70_24 |
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