Identifying Genetic Risk Factors for Diabetic Macular Edema and the Response to Treatment
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes mellitus (DM). DR is complex and the term encompasses several clinical subtypes of diabetic eye disease, including diabetic macular edema (DME), the most frequent cause of central vision loss in DR patients. Both gen...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/5016916 |
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| author | Rajya L. Gurung Liesel M. FitzGerald Bennet J. McComish Nitin Verma Kathryn P. Burdon |
| author_facet | Rajya L. Gurung Liesel M. FitzGerald Bennet J. McComish Nitin Verma Kathryn P. Burdon |
| author_sort | Rajya L. Gurung |
| collection | DOAJ |
| description | Diabetic retinopathy (DR) is the most common microvascular complication of diabetes mellitus (DM). DR is complex and the term encompasses several clinical subtypes of diabetic eye disease, including diabetic macular edema (DME), the most frequent cause of central vision loss in DR patients. Both genetic and environmental factors contribute to the pathophysiology of DR and its subtypes. While numerous studies have identified several susceptibility genes for DR, few have investigated the impact of genetics on DME susceptibility. This review will focus on the current literature surrounding genetic risk factors associated with DME. We will also highlight the small number of studies investigating the genetics of response to antivascular endothelial growth factor (anti-VEGF) injection, which is used to treat DME. |
| format | Article |
| id | doaj-art-3fa1aa6fd5bc40bfa1c91cead2e5eb91 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-3fa1aa6fd5bc40bfa1c91cead2e5eb912025-08-20T02:08:03ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/50169165016916Identifying Genetic Risk Factors for Diabetic Macular Edema and the Response to TreatmentRajya L. Gurung0Liesel M. FitzGerald1Bennet J. McComish2Nitin Verma3Kathryn P. Burdon4Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, AustraliaMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, AustraliaMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, AustraliaSchool of Medicine, University of Tasmania, Hobart, TAS, AustraliaMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, AustraliaDiabetic retinopathy (DR) is the most common microvascular complication of diabetes mellitus (DM). DR is complex and the term encompasses several clinical subtypes of diabetic eye disease, including diabetic macular edema (DME), the most frequent cause of central vision loss in DR patients. Both genetic and environmental factors contribute to the pathophysiology of DR and its subtypes. While numerous studies have identified several susceptibility genes for DR, few have investigated the impact of genetics on DME susceptibility. This review will focus on the current literature surrounding genetic risk factors associated with DME. We will also highlight the small number of studies investigating the genetics of response to antivascular endothelial growth factor (anti-VEGF) injection, which is used to treat DME.http://dx.doi.org/10.1155/2020/5016916 |
| spellingShingle | Rajya L. Gurung Liesel M. FitzGerald Bennet J. McComish Nitin Verma Kathryn P. Burdon Identifying Genetic Risk Factors for Diabetic Macular Edema and the Response to Treatment Journal of Diabetes Research |
| title | Identifying Genetic Risk Factors for Diabetic Macular Edema and the Response to Treatment |
| title_full | Identifying Genetic Risk Factors for Diabetic Macular Edema and the Response to Treatment |
| title_fullStr | Identifying Genetic Risk Factors for Diabetic Macular Edema and the Response to Treatment |
| title_full_unstemmed | Identifying Genetic Risk Factors for Diabetic Macular Edema and the Response to Treatment |
| title_short | Identifying Genetic Risk Factors for Diabetic Macular Edema and the Response to Treatment |
| title_sort | identifying genetic risk factors for diabetic macular edema and the response to treatment |
| url | http://dx.doi.org/10.1155/2020/5016916 |
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