Can We Accurately Time the Administration of Antenatal Corticosteroids for Preterm Labor?
Background. Accurate timing of antenatal corticosteroids (ACS) has resulted in improved neonatal outcomes. Objectives. Our primary objective was to determine predictors for optimal timing of ACS in women presenting with spontaneous preterm labor. Study Design. A retrospective cohort study of women r...
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| Format: | Article |
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Wiley
2016-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2016/5054037 |
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| author | Paola Aghajanian Quy T. Nguyen Naomi H. Greene Kimberly D. Gregory |
| author_facet | Paola Aghajanian Quy T. Nguyen Naomi H. Greene Kimberly D. Gregory |
| author_sort | Paola Aghajanian |
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| description | Background. Accurate timing of antenatal corticosteroids (ACS) has resulted in improved neonatal outcomes. Objectives. Our primary objective was to determine predictors for optimal timing of ACS in women presenting with spontaneous preterm labor. Study Design. A retrospective cohort study of women receiving ACS for spontaneous preterm birth was conducted. Women were included if they presented with preterm labor or preterm premature rupture of membranes. Accurate timing of ACS was defined as administration within 7 days of delivery. Maternal demographic and obstetrics characteristics were compared between the groups receiving ACS ≤7 days and >7 days from delivery. Statistical analyses were performed using parametric and nonparametric tests. P<0.05 was considered significant. Results. The study included 215 subjects. Median latency from ACS administration to delivery was 6 days (IQR 32). Accurate timing of ACS occurred in 113 (53%) women and was associated with rupture of membranes (OR 13.8, 95% CI 5.9–32.6), cervical change (OR 7.1, 95% CI 3.0–17.1), and cervical dilation ≥ 2 cm (OR 3.9, 95% CI 1.5–10.3). Conclusions. Rupture of membranes, cervical change, and cervical dilation ≥ 2 cm were strong predictors of optimal timing. 53% of women with preterm labor received ACS optimally. |
| format | Article |
| id | doaj-art-3fa0fe4e371e4160b66823c2611db564 |
| institution | OA Journals |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
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| series | Obstetrics and Gynecology International |
| spelling | doaj-art-3fa0fe4e371e4160b66823c2611db5642025-08-20T02:08:03ZengWileyObstetrics and Gynecology International1687-95891687-95972016-01-01201610.1155/2016/50540375054037Can We Accurately Time the Administration of Antenatal Corticosteroids for Preterm Labor?Paola Aghajanian0Quy T. Nguyen1Naomi H. Greene2Kimberly D. Gregory3Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USADivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USADivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USADivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USABackground. Accurate timing of antenatal corticosteroids (ACS) has resulted in improved neonatal outcomes. Objectives. Our primary objective was to determine predictors for optimal timing of ACS in women presenting with spontaneous preterm labor. Study Design. A retrospective cohort study of women receiving ACS for spontaneous preterm birth was conducted. Women were included if they presented with preterm labor or preterm premature rupture of membranes. Accurate timing of ACS was defined as administration within 7 days of delivery. Maternal demographic and obstetrics characteristics were compared between the groups receiving ACS ≤7 days and >7 days from delivery. Statistical analyses were performed using parametric and nonparametric tests. P<0.05 was considered significant. Results. The study included 215 subjects. Median latency from ACS administration to delivery was 6 days (IQR 32). Accurate timing of ACS occurred in 113 (53%) women and was associated with rupture of membranes (OR 13.8, 95% CI 5.9–32.6), cervical change (OR 7.1, 95% CI 3.0–17.1), and cervical dilation ≥ 2 cm (OR 3.9, 95% CI 1.5–10.3). Conclusions. Rupture of membranes, cervical change, and cervical dilation ≥ 2 cm were strong predictors of optimal timing. 53% of women with preterm labor received ACS optimally.http://dx.doi.org/10.1155/2016/5054037 |
| spellingShingle | Paola Aghajanian Quy T. Nguyen Naomi H. Greene Kimberly D. Gregory Can We Accurately Time the Administration of Antenatal Corticosteroids for Preterm Labor? Obstetrics and Gynecology International |
| title | Can We Accurately Time the Administration of Antenatal Corticosteroids for Preterm Labor? |
| title_full | Can We Accurately Time the Administration of Antenatal Corticosteroids for Preterm Labor? |
| title_fullStr | Can We Accurately Time the Administration of Antenatal Corticosteroids for Preterm Labor? |
| title_full_unstemmed | Can We Accurately Time the Administration of Antenatal Corticosteroids for Preterm Labor? |
| title_short | Can We Accurately Time the Administration of Antenatal Corticosteroids for Preterm Labor? |
| title_sort | can we accurately time the administration of antenatal corticosteroids for preterm labor |
| url | http://dx.doi.org/10.1155/2016/5054037 |
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