Correlation analysis between patent ductus arteriosus and bronchopulmonary dysplasia in premature infants
Abstract Background To evaluate the correlation between patent ductus arteriosus (PDA) and bronchopulmonary dysplasia (BPD) in premature infants. Methods Retrospective analysis was performed on preterm infants with a gestational age(GA) of less than 32 weeks from 2019 to 2021. PDA premature infants...
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2025-08-01
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| Series: | Italian Journal of Pediatrics |
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| Online Access: | https://doi.org/10.1186/s13052-025-02100-w |
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| author | Hao Luo Yibo Liu Chongbing Yan Bowen Weng Laxiu Zhao Cheng Cai |
| author_facet | Hao Luo Yibo Liu Chongbing Yan Bowen Weng Laxiu Zhao Cheng Cai |
| author_sort | Hao Luo |
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| description | Abstract Background To evaluate the correlation between patent ductus arteriosus (PDA) and bronchopulmonary dysplasia (BPD) in premature infants. Methods Retrospective analysis was performed on preterm infants with a gestational age(GA) of less than 32 weeks from 2019 to 2021. PDA premature infants with BPD ( N = 70 ) or not ( N = 224) were enrolled for multivariate logistic regression exploring independent risk factors for BPD in PDA preterm infants. The nomogram model was employed for exhibiting risk factors and receiver operating characteristic curve (ROC) was used to evaluate model performance. Results (1) GA, birth weight (BW) and Apgar (5 min) score in BPD group were significantly lower than non-BPD group (p < 0.0001). (2) BPD group had a higher utilization rate of pulmonary surfactant, more infants receiving oxygen therapy through nasal catheters, and a longer oxygen therapy duration (p < 0.0001). (3) The proportion of haemodynamically significant patent ductus arteriosus(hsPDA)in BPD group was significantly higher than that in non-BPD group (p < 0.05). (4) The incidence of anemia and pulmonary hypertension in BPD group infants was significantly higher than that in non-BPD group (100% and > 50% in BPD, respectively, p < 0.05). (5) The goodness of fit test of calibration curve showed χ2 = 7.136, p = 0.522, and area under curve (AUC) was 0.799. Conclusions GA, BW and PDA diameter were independent risk factors for PDA merged with BPD. The smaller GA, the lower BW, the larger PDA diameter and the lower Apgar score (5 min), and the higher the risk of BPD in PDA infants. |
| format | Article |
| id | doaj-art-3f9e7d549abb4f03a7d52f95bdf16e07 |
| institution | Kabale University |
| issn | 1824-7288 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj-art-3f9e7d549abb4f03a7d52f95bdf16e072025-08-20T04:02:55ZengBMCItalian Journal of Pediatrics1824-72882025-08-0151111010.1186/s13052-025-02100-wCorrelation analysis between patent ductus arteriosus and bronchopulmonary dysplasia in premature infantsHao Luo0Yibo Liu1Chongbing Yan2Bowen Weng3Laxiu Zhao4Cheng Cai5Department of Neonatology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong UniversityDepartment of Neonatology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong UniversityDepartment of Neonatology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong UniversityDepartment of Neonatology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong UniversityObstetrical department, Shanghai Putuo District Women and Child Health HospitalDepartment of Neonatology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong UniversityAbstract Background To evaluate the correlation between patent ductus arteriosus (PDA) and bronchopulmonary dysplasia (BPD) in premature infants. Methods Retrospective analysis was performed on preterm infants with a gestational age(GA) of less than 32 weeks from 2019 to 2021. PDA premature infants with BPD ( N = 70 ) or not ( N = 224) were enrolled for multivariate logistic regression exploring independent risk factors for BPD in PDA preterm infants. The nomogram model was employed for exhibiting risk factors and receiver operating characteristic curve (ROC) was used to evaluate model performance. Results (1) GA, birth weight (BW) and Apgar (5 min) score in BPD group were significantly lower than non-BPD group (p < 0.0001). (2) BPD group had a higher utilization rate of pulmonary surfactant, more infants receiving oxygen therapy through nasal catheters, and a longer oxygen therapy duration (p < 0.0001). (3) The proportion of haemodynamically significant patent ductus arteriosus(hsPDA)in BPD group was significantly higher than that in non-BPD group (p < 0.05). (4) The incidence of anemia and pulmonary hypertension in BPD group infants was significantly higher than that in non-BPD group (100% and > 50% in BPD, respectively, p < 0.05). (5) The goodness of fit test of calibration curve showed χ2 = 7.136, p = 0.522, and area under curve (AUC) was 0.799. Conclusions GA, BW and PDA diameter were independent risk factors for PDA merged with BPD. The smaller GA, the lower BW, the larger PDA diameter and the lower Apgar score (5 min), and the higher the risk of BPD in PDA infants.https://doi.org/10.1186/s13052-025-02100-wBronchopulmonary dysplasiaPatent ductus arteriosusPremature infantsRisk factorsPrediction model |
| spellingShingle | Hao Luo Yibo Liu Chongbing Yan Bowen Weng Laxiu Zhao Cheng Cai Correlation analysis between patent ductus arteriosus and bronchopulmonary dysplasia in premature infants Italian Journal of Pediatrics Bronchopulmonary dysplasia Patent ductus arteriosus Premature infants Risk factors Prediction model |
| title | Correlation analysis between patent ductus arteriosus and bronchopulmonary dysplasia in premature infants |
| title_full | Correlation analysis between patent ductus arteriosus and bronchopulmonary dysplasia in premature infants |
| title_fullStr | Correlation analysis between patent ductus arteriosus and bronchopulmonary dysplasia in premature infants |
| title_full_unstemmed | Correlation analysis between patent ductus arteriosus and bronchopulmonary dysplasia in premature infants |
| title_short | Correlation analysis between patent ductus arteriosus and bronchopulmonary dysplasia in premature infants |
| title_sort | correlation analysis between patent ductus arteriosus and bronchopulmonary dysplasia in premature infants |
| topic | Bronchopulmonary dysplasia Patent ductus arteriosus Premature infants Risk factors Prediction model |
| url | https://doi.org/10.1186/s13052-025-02100-w |
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