Osteogenesis Imperfecta with Celiac Disease and Type II Diabetes Mellitus Associated: Improvement with a Gluten-Free Diet
Osteogenesis imperfecta (OI) is a genetic disease, with a connective tissue alteration, consisting in the presence of multiple spontaneous fractures or after minimal traumatism. Its association with other metabolic processes is rarely described. We present the clinical case of a female adult patien...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/813461 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552350093410304 |
|---|---|
| author | Luis Rodrigo Isabel Pérez-Martinez |
| author_facet | Luis Rodrigo Isabel Pérez-Martinez |
| author_sort | Luis Rodrigo |
| collection | DOAJ |
| description | Osteogenesis imperfecta (OI) is a genetic disease, with a connective tissue alteration, consisting in the presence of multiple spontaneous fractures or after minimal traumatism. Its association with other metabolic processes is rarely described.
We present the clinical case of a female adult patient of 43 years. From her infancy, she has had multiple fractures, needing several surgical interventions, and she was diagnosed of OI type 2 at adolescence age. Due mainly to difficulties in walking remaining in wheel-chair in the last three years, she was overweight with morbid obesity (BMI=45.4) and had a type-II DM associated. She suffered from recurrent abdominal pain and chronic diarrhea and was diagnosed of celiac disease (CD) with increased intraepithelial duodenal infiltration, being classified as lymphocytic enteritis, Marsh I type. She was put on a gluten-free diet (GFD), having lost 6 kg of weight after 6 months, with a good control of DM-II and presenting a significant clinical improvement. It is rewarding to search the presence of two coincidental metabolic diseases associated to OI, specially CD, because of the dramatic clinical benefit in the general found after putting on a GFD. |
| format | Article |
| id | doaj-art-3f9d5650ff6b4106ae42cae24c9bd662 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-3f9d5650ff6b4106ae42cae24c9bd6622025-02-03T05:58:47ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/813461813461Osteogenesis Imperfecta with Celiac Disease and Type II Diabetes Mellitus Associated: Improvement with a Gluten-Free DietLuis Rodrigo0Isabel Pérez-Martinez1Gastroenterology Service, Hospital Universitario Central de Asturias (HUCA), University of Oviedo, c/Celestino Villamil s. no. 33006, Oviedo, SpainGastroenterology Service, Hospital Universitario Central de Asturias (HUCA), University of Oviedo, c/Celestino Villamil s. no. 33006, Oviedo, SpainOsteogenesis imperfecta (OI) is a genetic disease, with a connective tissue alteration, consisting in the presence of multiple spontaneous fractures or after minimal traumatism. Its association with other metabolic processes is rarely described. We present the clinical case of a female adult patient of 43 years. From her infancy, she has had multiple fractures, needing several surgical interventions, and she was diagnosed of OI type 2 at adolescence age. Due mainly to difficulties in walking remaining in wheel-chair in the last three years, she was overweight with morbid obesity (BMI=45.4) and had a type-II DM associated. She suffered from recurrent abdominal pain and chronic diarrhea and was diagnosed of celiac disease (CD) with increased intraepithelial duodenal infiltration, being classified as lymphocytic enteritis, Marsh I type. She was put on a gluten-free diet (GFD), having lost 6 kg of weight after 6 months, with a good control of DM-II and presenting a significant clinical improvement. It is rewarding to search the presence of two coincidental metabolic diseases associated to OI, specially CD, because of the dramatic clinical benefit in the general found after putting on a GFD.http://dx.doi.org/10.1155/2012/813461 |
| spellingShingle | Luis Rodrigo Isabel Pérez-Martinez Osteogenesis Imperfecta with Celiac Disease and Type II Diabetes Mellitus Associated: Improvement with a Gluten-Free Diet Case Reports in Medicine |
| title | Osteogenesis Imperfecta with Celiac Disease and Type II Diabetes Mellitus Associated: Improvement with a Gluten-Free Diet |
| title_full | Osteogenesis Imperfecta with Celiac Disease and Type II Diabetes Mellitus Associated: Improvement with a Gluten-Free Diet |
| title_fullStr | Osteogenesis Imperfecta with Celiac Disease and Type II Diabetes Mellitus Associated: Improvement with a Gluten-Free Diet |
| title_full_unstemmed | Osteogenesis Imperfecta with Celiac Disease and Type II Diabetes Mellitus Associated: Improvement with a Gluten-Free Diet |
| title_short | Osteogenesis Imperfecta with Celiac Disease and Type II Diabetes Mellitus Associated: Improvement with a Gluten-Free Diet |
| title_sort | osteogenesis imperfecta with celiac disease and type ii diabetes mellitus associated improvement with a gluten free diet |
| url | http://dx.doi.org/10.1155/2012/813461 |
| work_keys_str_mv | AT luisrodrigo osteogenesisimperfectawithceliacdiseaseandtypeiidiabetesmellitusassociatedimprovementwithaglutenfreediet AT isabelperezmartinez osteogenesisimperfectawithceliacdiseaseandtypeiidiabetesmellitusassociatedimprovementwithaglutenfreediet |