Shifts in the spatiotemporal profile of inflammatory phenotypes of innate immune cells in the rat brain following acute intoxication with the organophosphate diisopropylfluorophosphate

Shifts in the spatiotemporal profile of inflammatory phenotypes of innate immune cells in the rat brain following acute intoxication with the organophosphate diisopropylfluorophosphate

Abstract Acute intoxication with cholinesterase inhibiting organophosphates (OP) can produce life-threatening cholinergic crisis and status epilepticus (SE). Survivors often develop long-term neurological consequences, including spontaneous recurrent seizures (SRS) and impaired cognition. Numerous s...

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Bibliographic Details
Main Authors: Peter M. Andrew, Jeremy A. MacMahon, Pedro N. Bernardino, Yi-Hua Tsai, Brad A. Hobson, Valerie A. Porter, Sydney L. Huddleston, Audrey S. Luo, Donald A. Bruun, Naomi H. Saito, Danielle J. Harvey, Amy Brooks-Kayal, Abhijit J. Chaudhari, Pamela J. Lein
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Neuroinflammation
Subjects:
Astrocytes
Microglia
Nerve agent
Pesticide
Seizures
Status epilepticus
Online Access:https://doi.org/10.1186/s12974-024-03272-8
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