Intraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center Experiences
Breast-conserving surgery followed by whole-breast irradiation is the standard local therapy for early breast cancer. The international discussion of reduced importance of wider tumor-free resection margins than “tumor not touching ink” leads to the development of five principles in targeted oncopla...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2014/637898 |
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| author | Wolfram Malter Verena Kirn Lisa Richters Claudius Fridrich Birgid Markiefka Rudolf Bongartz Robert Semrau Peter Mallmann Stefan Kraemer |
| author_facet | Wolfram Malter Verena Kirn Lisa Richters Claudius Fridrich Birgid Markiefka Rudolf Bongartz Robert Semrau Peter Mallmann Stefan Kraemer |
| author_sort | Wolfram Malter |
| collection | DOAJ |
| description | Breast-conserving surgery followed by whole-breast irradiation is the standard local therapy for early breast cancer. The international discussion of reduced importance of wider tumor-free resection margins than “tumor not touching ink” leads to the development of five principles in targeted oncoplastic breast surgery. IORT improves local recurrence risk and diminishes toxicity since there is less irradiation of healthy tissue. Intraoperative radiotherapy (IORT) can be delivered in two settings: an IORT boost followed by a conventional regimen of external beam radiotherapy or a single IORT dose. The data from TARGIT-A and ELIOT reinforce the conviction that intraoperative radiotherapy during breast-conserving surgery is a reliable alternative to conventional postoperative fractionated irradiation, but only in a carefully selected population at low risk of local recurrence. We describe our experiences with IORT boost (50 kV energy X-rays; 20 Gy) in combination with targeted oncoplastic breast surgery in a routine clinical setting. Our experiences demonstrate the applicability and reliability of combining IORT boost with targeted oncoplastic breast surgery in breast-conserving therapy of early breast cancer. |
| format | Article |
| id | doaj-art-3f98291d62be4265bfb690e3aefa1538 |
| institution | OA Journals |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-3f98291d62be4265bfb690e3aefa15382025-08-20T02:08:04ZengWileyInternational Journal of Breast Cancer2090-31702090-31892014-01-01201410.1155/2014/637898637898Intraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center ExperiencesWolfram Malter0Verena Kirn1Lisa Richters2Claudius Fridrich3Birgid Markiefka4Rudolf Bongartz5Robert Semrau6Peter Mallmann7Stefan Kraemer8Breast Center, University Hospital of Cologne, Kerpenerstrasse 34, 50931 Cologne, GermanyBreast Center, University Hospital of Cologne, Kerpenerstrasse 34, 50931 Cologne, GermanyBreast Center, University Hospital of Cologne, Kerpenerstrasse 34, 50931 Cologne, GermanyBreast Center, University Hospital of Cologne, Kerpenerstrasse 34, 50931 Cologne, GermanyDepartment of Pathology, University Hospital of Cologne, Kerpenerstrasse 34, 50931 Cologne, GermanyDepartment of Radiotherapy, University Hospital of Cologne, Kerpenerstrasse 34, 50931 Cologne, GermanyDepartment of Radiotherapy, University Hospital of Cologne, Kerpenerstrasse 34, 50931 Cologne, GermanyDepartment of Obstetrics and Gynaecology, University Hospital of Cologne, Kerpenerstrasse 34, 50931 Cologne, GermanyBreast Center, University Hospital of Cologne, Kerpenerstrasse 34, 50931 Cologne, GermanyBreast-conserving surgery followed by whole-breast irradiation is the standard local therapy for early breast cancer. The international discussion of reduced importance of wider tumor-free resection margins than “tumor not touching ink” leads to the development of five principles in targeted oncoplastic breast surgery. IORT improves local recurrence risk and diminishes toxicity since there is less irradiation of healthy tissue. Intraoperative radiotherapy (IORT) can be delivered in two settings: an IORT boost followed by a conventional regimen of external beam radiotherapy or a single IORT dose. The data from TARGIT-A and ELIOT reinforce the conviction that intraoperative radiotherapy during breast-conserving surgery is a reliable alternative to conventional postoperative fractionated irradiation, but only in a carefully selected population at low risk of local recurrence. We describe our experiences with IORT boost (50 kV energy X-rays; 20 Gy) in combination with targeted oncoplastic breast surgery in a routine clinical setting. Our experiences demonstrate the applicability and reliability of combining IORT boost with targeted oncoplastic breast surgery in breast-conserving therapy of early breast cancer.http://dx.doi.org/10.1155/2014/637898 |
| spellingShingle | Wolfram Malter Verena Kirn Lisa Richters Claudius Fridrich Birgid Markiefka Rudolf Bongartz Robert Semrau Peter Mallmann Stefan Kraemer Intraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center Experiences International Journal of Breast Cancer |
| title | Intraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center Experiences |
| title_full | Intraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center Experiences |
| title_fullStr | Intraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center Experiences |
| title_full_unstemmed | Intraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center Experiences |
| title_short | Intraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center Experiences |
| title_sort | intraoperative boost radiotherapy during targeted oncoplastic breast surgery overview and single center experiences |
| url | http://dx.doi.org/10.1155/2014/637898 |
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