Do Nutritional Supplements Have a Role in Age Macular Degeneration Prevention?
Purpose. To review the proposed pathogenic mechanisms of age macular degeneration (AMD), as well as the role of antioxidants (AOX) and omega-3 fatty acids (ω-3) supplements in AMD prevention. Materials and Methods. Current knowledge on the cellular/molecular mechanisms of AMD and the epidemiologic/e...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2014/901686 |
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| author | Maria D. Pinazo-Durán Francisco Gómez-Ulla Luis Arias Javier Araiz Ricardo Casaroli-Marano Roberto Gallego-Pinazo Jose J. García-Medina Maria Isabel López-Gálvez Lucía Manzanas Anna Salas Miguel Zapata Manuel Diaz-Llopis Alfredo García-Layana |
| author_facet | Maria D. Pinazo-Durán Francisco Gómez-Ulla Luis Arias Javier Araiz Ricardo Casaroli-Marano Roberto Gallego-Pinazo Jose J. García-Medina Maria Isabel López-Gálvez Lucía Manzanas Anna Salas Miguel Zapata Manuel Diaz-Llopis Alfredo García-Layana |
| author_sort | Maria D. Pinazo-Durán |
| collection | DOAJ |
| description | Purpose. To review the proposed pathogenic mechanisms of age macular degeneration (AMD), as well as the role of antioxidants (AOX) and omega-3 fatty acids (ω-3) supplements in AMD prevention. Materials and Methods. Current knowledge on the cellular/molecular mechanisms of AMD and the epidemiologic/experimental studies on the effects of AOX and ω-3 were addressed all together with the scientific evidence and the personal opinion of professionals involved in the Retina Group of the OFTARED (Spain). Results. High dietary intakes of ω-3 and macular pigments lutein/zeaxanthin are associated with lower risk of prevalence and incidence in AMD. The Age-Related Eye Disease study (AREDS) showed a beneficial effect of high doses of vitamins C, E, beta-carotene, and zinc/copper in reducing the rate of progression to advanced AMD in patients with intermediate AMD or with one-sided late AMD. The AREDS-2 study has shown that lutein and zeaxanthin may substitute beta-carotene because of its potential relationship with increased lung cancer incidence. Conclusion. Research has proved that elder people with poor diets, especially with low AOX and ω-3 micronutrients intake and subsequently having low plasmatic levels, are more prone to developing AMD. Micronutrient supplementation enhances antioxidant defense and healthy eyes and might prevent/retard/modify AMD. |
| format | Article |
| id | doaj-art-3f976f07340945f2a474d154ab4abc3a |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-3f976f07340945f2a474d154ab4abc3a2025-08-20T03:55:36ZengWileyJournal of Ophthalmology2090-004X2090-00582014-01-01201410.1155/2014/901686901686Do Nutritional Supplements Have a Role in Age Macular Degeneration Prevention?Maria D. Pinazo-Durán0Francisco Gómez-Ulla1Luis Arias2Javier Araiz3Ricardo Casaroli-Marano4Roberto Gallego-Pinazo5Jose J. García-Medina6Maria Isabel López-Gálvez7Lucía Manzanas8Anna Salas9Miguel Zapata10Manuel Diaz-Llopis11Alfredo García-Layana12University of Valencia, SpainUniversity of Santiago de Compostela, SpainUniversity of Barcelona, SpainVitreous and Retina Department, UPV/EHU and Instituto Clínico Quirúrgico de Oftalmología (ICQO), University of the Basque Country, Bilbao, SpainClinic Institute of Ophthalmology, Clinic Hospital of Barcelona, University of Barcelona, Barcelona, SpainMacula Section, Department of Ophthalmology, University and Polytechnic Hospital La Fe, Valencia, SpainUniversity of Murcia, General University Hospital Reina Sofia, Murcia, SpainThe University of Valladolid, Diabetes and Telemedicine Unit at the IOBA, SpainThe University of Valladolid, SpainResearch Institute of the Hospital of Vall Hebron, Barcelona, SpainRetina Section of the Hospital of Vall Hebron, The Universidad Autònoma de Barcelona, Barcelona, SpainFaculty of Medicine, University of Valencia, Valencia, SpainUniversity of Navarra Clinic, Pamplona, SpainPurpose. To review the proposed pathogenic mechanisms of age macular degeneration (AMD), as well as the role of antioxidants (AOX) and omega-3 fatty acids (ω-3) supplements in AMD prevention. Materials and Methods. Current knowledge on the cellular/molecular mechanisms of AMD and the epidemiologic/experimental studies on the effects of AOX and ω-3 were addressed all together with the scientific evidence and the personal opinion of professionals involved in the Retina Group of the OFTARED (Spain). Results. High dietary intakes of ω-3 and macular pigments lutein/zeaxanthin are associated with lower risk of prevalence and incidence in AMD. The Age-Related Eye Disease study (AREDS) showed a beneficial effect of high doses of vitamins C, E, beta-carotene, and zinc/copper in reducing the rate of progression to advanced AMD in patients with intermediate AMD or with one-sided late AMD. The AREDS-2 study has shown that lutein and zeaxanthin may substitute beta-carotene because of its potential relationship with increased lung cancer incidence. Conclusion. Research has proved that elder people with poor diets, especially with low AOX and ω-3 micronutrients intake and subsequently having low plasmatic levels, are more prone to developing AMD. Micronutrient supplementation enhances antioxidant defense and healthy eyes and might prevent/retard/modify AMD.http://dx.doi.org/10.1155/2014/901686 |
| spellingShingle | Maria D. Pinazo-Durán Francisco Gómez-Ulla Luis Arias Javier Araiz Ricardo Casaroli-Marano Roberto Gallego-Pinazo Jose J. García-Medina Maria Isabel López-Gálvez Lucía Manzanas Anna Salas Miguel Zapata Manuel Diaz-Llopis Alfredo García-Layana Do Nutritional Supplements Have a Role in Age Macular Degeneration Prevention? Journal of Ophthalmology |
| title | Do Nutritional Supplements Have a Role in Age Macular Degeneration Prevention? |
| title_full | Do Nutritional Supplements Have a Role in Age Macular Degeneration Prevention? |
| title_fullStr | Do Nutritional Supplements Have a Role in Age Macular Degeneration Prevention? |
| title_full_unstemmed | Do Nutritional Supplements Have a Role in Age Macular Degeneration Prevention? |
| title_short | Do Nutritional Supplements Have a Role in Age Macular Degeneration Prevention? |
| title_sort | do nutritional supplements have a role in age macular degeneration prevention |
| url | http://dx.doi.org/10.1155/2014/901686 |
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