Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in Adolescents
Considerable evidence has suggested that the epigenetic regulation of N-methyl-D-aspartate (NMDA) glutamate receptors plays a crucial role in neuropsychiatric disorders. Previous exploratory studies have been primarily based on evidence from patients and have rarely sampled the general population. T...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/6851592 |
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| author | Li-Ching Lee Ying-Chun Cho Pei-Jung Lin Ting-Chi Yeh Chun-Yen Chang Ting-Kuang Yeh |
| author_facet | Li-Ching Lee Ying-Chun Cho Pei-Jung Lin Ting-Chi Yeh Chun-Yen Chang Ting-Kuang Yeh |
| author_sort | Li-Ching Lee |
| collection | DOAJ |
| description | Considerable evidence has suggested that the epigenetic regulation of N-methyl-D-aspartate (NMDA) glutamate receptors plays a crucial role in neuropsychiatric disorders. Previous exploratory studies have been primarily based on evidence from patients and have rarely sampled the general population. This exploratory study examined the relationship of single-nucleotide polymorphism (SNP) variations in the genes encoding the NMDA receptor (i.e., GRIN1, GRIN2A, GRIN2B, GRIN2C, and GRIN2D) with emotion and social behavior in adolescents. For this study, 832 tenth-grade Taiwanese volunteers were recruited, and their scores from the Beck Youth Inventories were used to evaluate their emotional and social impairments. Based on these scores, GRIN1 (rs4880213) was significantly associated with depression and disruptive behavior. In addition, GRIN2B (rs7301328) was significantly associated with disruptive behavior. Because emotional and social impairment greatly influence learning ability, the findings of this study provide important information for clinical treatment and the development of promising prevention and treatment strategies, especially in the area of psychological adjustment. |
| format | Article |
| id | doaj-art-3f86d47162b24e5fb8cc5cf51e4ef327 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-3f86d47162b24e5fb8cc5cf51e4ef3272025-02-03T01:28:50ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/68515926851592Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in AdolescentsLi-Ching Lee0Ying-Chun Cho1Pei-Jung Lin2Ting-Chi Yeh3Chun-Yen Chang4Ting-Kuang Yeh5Science Education Center and Graduate Institute of Science Education, National Taiwan Normal University, 88 Section 4, Ting-Chou Road, Taipei 116, TaiwanScience Education Center and Graduate Institute of Science Education, National Taiwan Normal University, 88 Section 4, Ting-Chou Road, Taipei 116, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University Hospital, No. 1, Section 1, Jen-Ai Road, Taipei 100, TaiwanDepartment of Pediatrics, Mackay Memorial Hospital, 92 Section 2, Zhongshan N. Road, Taipei 104, TaiwanScience Education Center and Graduate Institute of Science Education, National Taiwan Normal University, 88 Section 4, Ting-Chou Road, Taipei 116, TaiwanScience Education Center and Graduate Institute of Science Education, National Taiwan Normal University, 88 Section 4, Ting-Chou Road, Taipei 116, TaiwanConsiderable evidence has suggested that the epigenetic regulation of N-methyl-D-aspartate (NMDA) glutamate receptors plays a crucial role in neuropsychiatric disorders. Previous exploratory studies have been primarily based on evidence from patients and have rarely sampled the general population. This exploratory study examined the relationship of single-nucleotide polymorphism (SNP) variations in the genes encoding the NMDA receptor (i.e., GRIN1, GRIN2A, GRIN2B, GRIN2C, and GRIN2D) with emotion and social behavior in adolescents. For this study, 832 tenth-grade Taiwanese volunteers were recruited, and their scores from the Beck Youth Inventories were used to evaluate their emotional and social impairments. Based on these scores, GRIN1 (rs4880213) was significantly associated with depression and disruptive behavior. In addition, GRIN2B (rs7301328) was significantly associated with disruptive behavior. Because emotional and social impairment greatly influence learning ability, the findings of this study provide important information for clinical treatment and the development of promising prevention and treatment strategies, especially in the area of psychological adjustment.http://dx.doi.org/10.1155/2016/6851592 |
| spellingShingle | Li-Ching Lee Ying-Chun Cho Pei-Jung Lin Ting-Chi Yeh Chun-Yen Chang Ting-Kuang Yeh Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in Adolescents Neural Plasticity |
| title | Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in Adolescents |
| title_full | Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in Adolescents |
| title_fullStr | Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in Adolescents |
| title_full_unstemmed | Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in Adolescents |
| title_short | Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in Adolescents |
| title_sort | influence of genetic variants of the n methyl d aspartate receptor on emotion and social behavior in adolescents |
| url | http://dx.doi.org/10.1155/2016/6851592 |
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